2012, volume 8

The Research Objective: Correlation of apoptosis and senilism in patients with metabolic syndrome has been studied. Materials. Apoptosis inductor protein p53 concentration, insulin level in blood serum, biological age, ageing rate coefficient of 270 patients with metabolic syndrome of the age from 30 till 60 have been determined. Among them there have been 162 men and 108 women. Ageing rate coefficient and biological age have been calculated by A. G. Gorel-kin's and Pinchasov's formulae, protein p53 concentration and insulin in blood serum have been determined by enzyme multiplied immunoassay method. Results. Protein p53 concentration of the patients with metabolic syndrome has been increased and worked out 1,59 (1,361,91) U/ml, biological age, ageing rate coefficient have been increased — biological age to 6 years, ageing rate coefficient has been 1,32. Conclusion. These patients have been referred to the group with high risk of early pathology development because the processes of senilism are proleptic. The direct connection between protein p 53 and ageing rate coefficient (r+0,63, p< 0,05) and between apoptosis marker protein p53 and biological age (r+0,6, p< 0,05) have been determined.

Research objective is to determine the influence of adaptation method to periodic pressure chamber hypoxia on dynamics of systolic and diastolic functions of myocardium in patients with early stages of chronic heart failure. Materials and Methods: 100 men with post-infarction cardiosclerosis at the age of 40-65 years with I and IIA stages and l-ll functional classes (NYHA) of chronic heart failure have been examined. Results: Positive dynamics of systolic and diastolic cardiac functions and other parameters of echocardioscopy under the influence of the hypoxic therapy in comparison with classical physical rehabilitation have been obtained. Furthermore, a more significant effect has been observed in patients with CHF IIA. Conclusion: Improvement in the geometry of the heart has proved that adaptation method to periodic pressure chamber hypoxia could be recommended for rehabilitation of patients with heart failure of early stages.

The results of complete clinical and demographic investigation of Volga Region population of long-livers have been presented. Anthropologic, social, clinical, laboratory and instrumental markers of longevity have been determined.

Aim: The definition of the relationship of clinical and laboratory features of acute myocardial infarction depending on the suffering of chronic tonsillitis. Materials and methods. The study included 54 patients with acute myocardial infarction suffering for 1-2 days. The collection of the anamnesis, assessment of clinical factors, inspection of the palatine tonsils, clinical and biochemical blood tests have been done. Markers of myocardial necrosis, an electrocardiogram with calculation of a dispersion of interval QT, echocardiogram have been taken into account. Results. 45 of 54 patients reported the symptoms of chronic tonsillitis in their lifetime. At 17 patients the previous diagnosis of chronic tonsillitis has been made, in 6 of them bilateral tonsillectomy was held. All of the patients were divided into 2 groups: 1 with proven chronic tonsillitis (17 patients) and 2 — the others (37 patients). At patients with chronic tonsillitis substantially more developed acute heart failure at sick this group glucose of the blood at receipt was higher than in 2 groups (p=0,004), given distinction was independent of presence of diabetes. According to the echocardiography 1 group of patients determined course-diastolic dimensions of the right ventricle increase in comparison with 2 groups (p=0,01). Conclusion. In patients with chronic tonsillitis more severe course of acute myocardial infarction has been determined, which became evident in the relatively high values of blood glucose on admission. The frequent development of congestive heart failure, and increase of the course-diastolic dimensions of the right ventricle have been also revealed.

The research work is devoted to irritable bowel syndrome (IBS) as an independent nosological unity of modern gas-troenterology. Risk factors, clinical manifestations and diagnostic methods of IBS have been analyzed. Psychological and social characteristics in the development of IBS have been examined

Purpose: to study the morphological characteristic of a coronary blood flow and feature of erythronJs system at ischemic heart disease in aged patients. Methods. Morphological and functional characteristics of coronary blood flow (according to the data of selective direct angiocoronarography) and also cytomorphological and functional parameters of peripheral blood flow in aged patients with ischemic heart disease have been used. Results. Statistically reliable differences to parameters of «red» blood are determined. Lowering of erythrocytes has been established in women. The parameters of haemoglobin level, hematocrit and increasing of erythrocyte sedimentation rate was marked in both gender. The gender distinctions of age have been revealed remodeling of coronary arteries. Conclusion. The high probability of erythronJs system participation has been shown namely its peripheral link in process of age remodeling of coronary arteries in aged men with ischemic heart disease

Tropicality. Cardiomyopathies (CMP) are diseases of unknown etiology. CMP are usually diagnosed in late stages of the disease. The search for diagnostic methods for CMP in the early stage is of great importance. The purpose is to determine the character of distribution of polymorph genetic variations rates of angiotensin converting enzyme (ACE), glutathione S- transferase (GSTM 1) among CMP patients and healthy subjects living in the Republic of Bashkortostan and to substantiate their value in CMP pathogenesis. Materials and methods. A total of 67 patients with CMP were included in the study. Out of them, 40 patients were diagnosed with ischemic cardiomyopathy (ICMP) and 27 patients — dilatation cardiomyopathy (DCMP). 110 healthy persons were enrolled in the control group. Results. In the group of patients with ICMP, the genotype DD (x2=4,81; p=0,029) occurred more frequently. In DCMP group, there was also an increase in frequency of DD genotype of polymorph genetic locus of ACE gene (%2=4,046; p=0,044). Conclusion. Genetic analysis of polymorph l/D locus of ACE gene in patients with ICMP and DCMP showed a decrease in occurrence rates of II, ID genotypes, allele I, as well as an increase in DD genotypes and allele D. This is associated with an increased risk for the development of these cardiovascular diseases

Objective: To study the clinical features of the course and outcome of pregnancy accompanied by acute respiratory viral infections and influenza A (HN^win). Methods and materials. 152 pregnant women who suffered from influenza A (H l^swin), acute respiratory viral infections in different duration of gestation. Results. Similar clinical symptomatology of both influenza A (H1N1 swin) and acute respiratory viral infections during the period of epidemic raise of influenza allow to suggest present nosology including pregnant patients with acute respiratory viral infections. Conclusion. In 4 cases the fatal outcome from influenza related to presence of associated pathology and development of the severe form of influenza complicated by acute respiratory and cardiovascular insufficiency, pulmonary edema, and cerebral edema were registered

Research objective: To define clinical predictors of adverse course of nonspecific bacterial vulvovaginitis (NBV) at girls born from mothers with the undifferentiated forms of dysplasia of connective tissue (UFDCT). Materials: At 157 girls clinical research, bacteriological and bacterioscopy research of leucorrhoea from vagina has been conducted, NBV has been diagnosed at 111 girls. At all girls and at their mothers the immunity has been investigated; at all mothers of girls with NBV phenotypic reveals of UFDCT have been found out. Results: At girls with NBV born from mothers with UFDCT severe course of a disease has been marked; and at mothers with UFDCT and at their children with NBV disorders of humoral immunity have been revealed. Presence of more than 5 stigmas of dysembryogenesis with prevalence of thoracodiaphragmatic, articular, cosmetic syndromes and pathology of organs of vision at mothers of girls with NBV is possible to use as predictors of adverse course of the disease

Research Objective: To compare the features of personal response in young patients with minor heart anomalies according to gender and severity of abnormalities. Materials and Methods: Physiological characteristics of 124 male and female (mean age — 22,16±2,42 years) have been examined by means of Toronto Alexithymic scale, reduced multifactorial questionnaire for the study of personality and psychogeometric test. Results: It has been found that both women and men with moderate degree of minor heart anomalies manifest polar intrapsychic tendencies, higher levels of alexithymia than in those with a lesser degree of dysplasia of the connective tissue of the heart. Conclusion: Patients with moderate degree of minor heart anomalies have experienced the conflicting intrapsychic tendencies and higher levels of alexithymia than patients with minor heart anomalies of a minimal degree, regardless of the gender. Male patients with varying degrees of severity are more likely to suffer from alexithymia than females