2012, volume 8

The aim of the research is to study and to analyze results of investigations of cytokine blood profile in patients with B-cellular chronic lymphocytic leukaemia. Materials and methods: Complex investigation of 60 patients with B-cellular chronic lymphocytic leukaemia has been carried out. Patients have been randomized into 4 groups of observation according to the severety of disease (classification of Rai K. R., 1975). Accepted methods of somatic status and he-matologic indices as well as method of flow cytometry for establishment of B-lymphocytes immune phenotype have been used. Cytokine levels were detected by enzyme immunodetection. Results: Regular peculiarity of cytokine status change in different forms of chronic lymphocytic leukaemia development has been an increase of interleukine-4, interleukine-6, interleukine-7, interleukine-10 and tumor necrosis factor-alpha levels in serum that is one of the main pathogenetic factor of intercellular interaction abnormality in lymphoid tissue in the chronic lymphocytic leukaemia development. Conclusion: Increased indications of cytokines content in blood may be used as diagnostic criteria of pathology severity and in evaluation of effectiveness of complex therapy of the disease, as well as a classification sign of severity of chronic lymphocytic leukaemia

In a new foreign market strategy of adaptation of the regional department of an international pharmaceutical company has its own peculiarities that arise from the specifics of the pharmaceutical market. In article the strategy to adapt to the new market has been discussed, as conceived plan for use of any of options available to the regional office. This range of options for adaptation will vary depending on the level of competition in different segments of the new market. In his article the author, based on the specifics of the pharmaceutical market, examines the impact of factors such as «competition» to choose a set of possibilities to adapt the regional office. The article is classified in the new market segments based on consumer awareness and choice in the way of treatment. In his article, the author discusses the different feature sets for adaptation the regional branch of pharmaceutical company in the new market. Conclusion: To achieve the desired level of adaptation to the new market under the current conditions (when the balance of power in favor of an informed buyer and seller competition), the regional office has to acquire and use every opportunity not only to meet but to exceed customer expectations

The article considers the main theoretical issues of psychosomatics. It provides an overview of psychosomatic genesis models. The hypotheses of psychobiological nature of cancer and the mechanism of the placebo effect have been under the study. The general model of psychosomatic work has been worked out. The article provides a brief overview of psychotherapeutic techniques used in the work with somatic diseases, where the main attention has been paid to the procedural and hypnotherapeutic techniques. It discusses the integration of psychosomatics and somatic medicine

The main condition in achieving a favorable outcome is surgical treatment of patients with tumor-like diseases and benign bone tumors erosion of neoplasm within the healthy tissues. To reduce the number of recurrences the various chemical and physical methods on resection areas have been performed. The authors have proposed a new method of low temperature plasma treatment of bone tissue with the temperature of 20000°C. Exposing the plasma flow on bone tissue leads to loss of all cellular elements including neoplastic elements with preservation of the mineral bone structure. The direct correlation between the capacity of the plasma flow and intensity of bone destruction has been defined. This allows a differentiated use of plasma destruction in skeletal bones according to anatomy, size and type of bone tissue (spongy or cortical) as well as patient's individual condition of the tissue

The research article is devoted to the study of structural characteristics of prostate according to the young men constitution. Materials and methods: 540 vertical and horizontal sections of prostate have been investigated. Results: Size characteristics of prostate have been established in men of different somatotypes

The article is devoted to recurring adaptation effect on energy metabolism of atrophic shin muscles. The purpose: Investigation of markers of activity of muscular fibers of gravitation-dependent muscles in condition of early posthypoki-netic readaptation. Materials. Muscles-antagonists have been taken from the shin area of hind limbs of a rat. Methods. Immunohistochemical dyeing of myofibrils of different type (I and II) on glycogen and triglycerides have been used. Results. We have revealed dynamic changes of the endocellular contents of researched energy substrata on different terms of the period of posthypokinetic restoration. Conclusion. Investigated substrata my serve as adequate functional markers of muscles in the conditions under the study

Purpose: to reveal regularities of variability of morphometric parameters of foramen of transverse process of cervical vertebra. Materials and Methods. Method of osteometry was used to determine size of transverse process of cervical vertebra at 112 adult skeletons. Results. Sexual dimorphism of size of transverse process of cervical vertebra, topographic variability of size, form and foramen orientations were revealed. Conclusion. Foramen size prevail at men over women by 0,5-1,5 mm and has characteristic of fluctuating dissymmetry

The article discusses the positive and negative impact of the new Federal state educational standards of higher professional education on the quality of studying the discipline «Law» in medical schools

The article analyzes the literature on the issue of regulation of erythropoietin in patients with type 1 diabetes. The connection between the secretion of erythropoietin disturbance with the development and progression of diabetes complications has been observed. Various pleiotropic effects of erythropoietin have been considered

The histotypic structure of nodular growths has been morphologically studied after the primary surgery and reinter-vention. The revealed difference may indicate either the new thyroid tissue formation or the initial diagnosis error and inadequate surgery. Histological changes of the thyroid gland are caused by both the external (surgery, anthropogenic influence) and internal (reparative processes, dystrophic changes, hormone biosynthesis disturbance) factors, including iodine metabolism. It results in postoperative goiter development