2012, volume 8

Research objective: To estimate cytogenetic effect of dentures on the condition of buccal epithelium by means of the micronuclear test. Materials and methods: For this test the most convenient object of the research is nonkeratinized stratified epithelium which has been taken from 24 patients before prosthetics. Statistical data processing has been done by means of a package of statistical programs «Stadia». Results: The increase in frequency of occurrence of cells with micronuclei in buccal epithelium in patients after the prosthetics that testifies to stability disturbance of genetic material in the studied cells. Influence of fillings and dentures has been revealed. Conclusion: It allows to apply safe materials in stomatology, having reduced their side effects on an organism as a whole

The Research Objective: To study patients with prosthetic stomatitis, who use the removable laminar dentures. Materials: The consultations and treatment of 79 patients aged 47-65 years have been conducted. The patients have been divided into two clinical groups. The first clinical group (39 persons) with the performance of immediate prosthet-ics; the second control clinical group (40 persons) — the permanent dentures were produced without the preliminary instruction. Results: All the patients, having the laminar dentures without the preliminary use of immediate constructions of dentures, in spite of repeated correction of them, have had changes of dentures and transitory fold. Patients have been exposed to prosthetic stomatitis of different etiology (without trauma); the single-shot or multiple correction of dentures by the method of rebasing with using of cold cure plastics has been made. Conclusion: Structural and functional changes of dentition during the prosthetic stomatitis lead to disorders, associated by the mucositis. Use of the term of «prosthetic stomatitis» reflects etiological and pathogenetic component of changes in the denture-supporting tissues

Objective: To study clinical-morphological characteristics of parodontal diseases, markers of density of bone tissue and to define rational approaches to prosthetics of defects of dentitions in patients with colon diseases. Materials and methods: 55 patients with ulcerative colitis, even 80 with the syndrome of the irritable bowel syndrome with defects of dentitions, have been applied metallic, cement prostheses and having prostheses on the intraosseous of implants. Markers of bone metabolism in the blood serum and in the oral liquid, the proliferating activity of the epitheliocytes of periodontium have been evaluated according to the morphometric indices of the markers of the proliferation of ki-67, cyclein D1, the inhibitor of apoptosis of bcl-2 have been inspected. Results: Connection of intensity of periodontitis with the stage of colon disease has been stated. Metallic dental prostheses have been served as additional risk factors of development of parodontal diseases in patients with ulcerative colitis. Conclusion: The diagnostic value of the markers of proliferation has been determined in diagnostics of parodontal disease during the application of prostheses from different materials.

The fetus of a man develops in difficult conditions of mutual relations, both with an organism of mother, and with environment, and consequently protection and strengthening of health of children should be carried out taking into account health of mother, the way of life, place of living, course of pregnancy and delivery. The research goal is to reveal the factors which are predictors of physical development of newborn children and drawing up of prognostic models of anthropometric indicators at birth. Materials and methods: Survey of 220 newborns born in time and their mothers has been conducted. The anthropometry has included measurement of body weight, length, head and breast circles in children at birth. Results: The analysis of somatic, infectious, obstetric and gynecologic incidence of mothers of studied children, and also the course of pregnancy and delivery has been carried out. Conclusion: According to the data physical development of newborn children has been influenced by a number of factors. During the research work the prognostic models have been determined allowing to define the factors influencing physical intrauterine development of a child.

The article presents the results of research of physical development of children of infant and early age living in the territory of Engels Municipal Union. The purpose: To prove necessity of working out of regional standards of physical development of children under three years. Material and methods: Anthropometrical investigation of children under three years living in territory of Engels Municipal Union has been carried out. Results: Regional features of physical development of healthy children of region and discrepancy of centile tables of physical development estimation of children of infant and early age have been revealed. Conclusion: The received data have confirmed necessity of regional centile tables of physical development estimation of children.

Research objective: Study of anatomic features of neurovascular conflict predisposing to neuralgic status development. Materials: Among 200 patients with neuralgia of the trigeminal nerve (NTN), 12 persons taken to the clinic for treatment have been in the condition of neuralgic status (NS). Results: Among 130 patients with trigeminal nerve radix (TNR) conflict with one stem of superior cerebellar artery (SCA) status has been developed in 3 patients (2,15%). At TNR conflict with two stems of superior cerebellar artery (SCA) neuralgic status has been developed in 2 out of 32 persons (6,25%). Three patients out of 9 (33%) being in conflict to TNR where superior cerebellar artery participated from the ventral side and the superior petrosus vein from the dorsal side have been hospitalized with neuralgic status. Two patients (50%) with NS out of 4 with SCA conflict from the ventral side and anterior inferior cerebellar artery from the dorsal side have been hospitalized. Neurovascular conflict of trigeminal nerve radix with two stems of superior cerebellar artery in front and stem of anterior inferior cerebellar artery behind have been found in 6 persons, two of them have been hospitalized in the condition of neuralgic status (33%). The influence upon trigeminal nerve radix has been observed either from the ventral side or from the dorsal one in the rest of 19 patients. Neuralgic status has not been found. Conclusion: The development of neuralgic status is predisposed by the conflict of trigeminal nerve radix with several vessels simultaneously damaging its ventral and dorsal surfaces.

Objective: To study the hormonal parameters in women of different age groups in hemorrhagic fever with renal syndrome. Materials and methods: We have studied the content of cortisol, thyrotropic hormone (TTH), triiodothyro-nine (T3), free thyroxin (FT4), luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, estradiol, progesterone, prolactin in blood serum of 62 women with moderate (33) and severe (29) HFRS forms age (17-62). They were divided into 2 groups: the first group (33 patients) women with the normal menstrual cycle, the second group (29 women) consisted of patients in climacteric period. Results: TTH secretion increase, T3 and FT4 — decrease with their normalization to the recovery period were registered in the thyroid system of the compared groups. Blood cortisol level was high during the illness. Gonadotropic hypophysis function study demonstrated that LH and blood prolactin concentrations were increased since oliguria period; FSH was authentic reduced. The indices of these hormones were restored to the normal level by the reconvalescence period. LH and FSH contents were authentic higher in women of the second group in comparison with the first group. The hyperprolactinemia was observed in both women groups during the whole period of disease. The increased progesterone and testosterone concentrations have been manifested in blood serum. The estradiol concentration had different direction tendencies. Conclusion: Thus, the complex study of hypophysic- thyreoid and gonadotropic hormone state of adrenal system and the sexual hormone levels in women of different age groups in HFRS revealed the hormone status indces changes due to the period and severity of the disease, connected with the virus action, intoxication, the general inflammation reactions and their age.

Research objective: comparative analysis of distant thermography, Doppler ultrasound and pupillary reactions in patients with primary open-angle glaucoma at various stages of the disease with compensated intraocular pressure. Materials. 129 patients (216 eyes) with diagnosis of POAG at various stages ofthe disease (the main group) have been examined. Intraocular pressure has been normalized with medications, or with medications + laser surgery. The control group has consisted of patients with initial and immature cataract of similar age and sex (30 patients — 52 eyes). All patients have experienced thermal, Doppler study, and a study of pupil response to light. Results. It has been revealed that the temperature ofthe open optic fissure in patients with POAG correlated with hemodynamics in the central retinal artery and short posterior ciliary arteries. It has been also noted the reduction of pupillary reaction in the progression of glaucoma optic neuropathy. Conclusion. Data of distant thermography, Doppler ultrasound and video recording of pupillary reaction are different with various stages of glaucoma process. The investigation allows to use these methods for monitoring of patients with primary open-angle glaucoma

The review presents the published data on the relevance of the problem of thromboembolic complications in atrial fibrillation, the peculiarities of anticoagulant therapy for this disease. The relationship of clinical characteristics of patients with anticoagulant dose adjustment algorithms has been described. The problem of ethical issues of out of clinical trials patients and the dynamics of their quality of life against the background of long-term use of anticoagulant have been considered.

The article presents computations on informational and analytical basis of public health database, that help to perform accurate monitoring, and detection of public health system state, as well as prognosis of further dynamics of public health system parameters for scientifically proved health care organization and decisions in management.