Saratov JOURNAL of Medical and Scientific Research

2012, volume 8

The evaluation of blood fow in the face skin by LDF method

Year: 2012, volume 8 Issue: №2 Pages: 615-621
Heading: Skin Diseases Article type: Original article
Authors: Davydova A.V., Morrison A.V., Utz S.R., Meglinski I.V., Lychagov V.V.
Organization: Saratov State Medical University, Saratov state university, University of Otago, New Zealand
Summary:

Aims. The research aimed the studying and optimizing of the possibility of measuring microcirculatory of blood fow in human skin by laser Doppler fowmetry (LDF) against the various topographic features of the peripheral blood supply of tissues. Materials and methods. 20 people of the age from 20 to 56 years without signs of skin lesions were examined by the LDF device. The LDF device has two radiation sources in the red light at a wavelength range of 650±30 nm and the near — infrared at a wavelength of 805±50 nm. The radiation was carried out with four receiving fbers arranged at distances of 1, 2, 3 and 4 mm from the illuminating fber. The state of microvasculature was studied at four points of skin — in the middle of the forehead, in the center of the right cheek and the symmetric point on the left cheek and chin area. We calculated the average values of microcirculation, its standard deviation and coeffcient of variation. Conclusions. By varying the distance from the illuminating fber to the receiving fber and the wavelength of incident light the values of the microcirculation in the different areas of healthy skin were estimated by laser Doppler fowmetry method (LDF). Tissue probes, the spatial localization of the LDF signal in the tissues and the effective depth of detection have been estimated by Monte Carlo method. It has been found out during the study that the LDF signal changes are directly related to the structural features of the structure of the microvasculature, the depth and density of functioning capillaries. The given method can be used to diagnose the state of biological object in the normal and pathological conditions, as well as evaluating the effectiveness of the treatment of various dermatoses.

Keywords: blood fow, laser Doppler floumetry, microcirculation

The evaluation of blood fow in the face skin by LDF method

Year: 2012, volume 8 Issue: №2 Pages: 615-621
Heading: Skin Diseases Article type: Original article
Authors: Davydova A.V., Morrison A.V., Utz S.R., Meglinski I.V., Lychagov V.V.
Organization: Saratov State Medical University, Saratov state university, University of Otago, New Zealand
Summary:

Aims. The research aimed the studying and optimizing of the possibility of measuring microcirculatory of blood fow in human skin by laser Doppler fowmetry (LDF) against the various topographic features of the peripheral blood supply of tissues. Materials and methods. 20 people of the age from 20 to 56 years without signs of skin lesions were examined by the LDF device. The LDF device has two radiation sources in the red light at a wavelength range of 650±30 nm and the near — infrared at a wavelength of 805±50 nm. The radiation was carried out with four receiving fbers arranged at distances of 1, 2, 3 and 4 mm from the illuminating fber. The state of microvasculature was studied at four points of skin — in the middle of the forehead, in the center of the right cheek and the symmetric point on the left cheek and chin area. We calculated the average values of microcirculation, its standard deviation and coeffcient of variation. Conclusions. By varying the distance from the illuminating fber to the receiving fber and the wavelength of incident light the values of the microcirculation in the different areas of healthy skin were estimated by laser Doppler fowmetry method (LDF). Tissue probes, the spatial localization of the LDF signal in the tissues and the effective depth of detection have been estimated by Monte Carlo method. It has been found out during the study that the LDF signal changes are directly related to the structural features of the structure of the microvasculature, the depth and density of functioning capillaries. The given method can be used to diagnose the state of biological object in the normal and pathological conditions, as well as evaluating the effectiveness of the treatment of various dermatoses.

Keywords: blood fow, laser Doppler floumetry, microcirculation

Studying of a wave activity condition and cellular metabolism of tissues in patients with perioral dermatitis

Year: 2012, volume 8 Issue: №2 Pages: 611-615
Heading: Skin Diseases Article type: Original article
Authors: Grashkina I.G., Grashkin V.A., Utz S.R.
Organization: Saratov State Medical University
Summary:

Perioral dermatitis is a facial skin disease with insuffciently studied ethiology and pathogenetic mechanisms, being one of actual problems of dermatology. It is a chronic relapsing facial skin disease mainly in women of young and middle age (in men and children meets less often). The disease has an independent clinical picture which is different from rosacea, demodecosis, seborrheic dermatitis, etc. The standard diagnostic criterion is a visual estimation of expression of an infammation on the basis of signs of exudative reaction which has a subjective character. Possibilities of a radiometric method for an objective estimation of a facial skin functional condition and indicators of an intracellular metabolism in patients with a perioral dermatitis were frst studied.

Keywords: wave activity, radiometric method, perioral dermatitis, intracellular metabolism, endogenous intoxication

The research of the vascular component of the microcirculation in tissues in the patients with perioral dermatitis by the method of active radiometry

Year: 2012, volume 8 Issue: №2 Pages: 608-611
Heading: Skin Diseases Article type: Original article
Authors: Grashkin V.A., Grashkina I.G., Utz S.R.
Organization: Saratov State Medical University
Summary:

The possibility of a non-invasive estimation of a condition of a vascular and extravasated component of microcir-culation in tissues in patients with perioral dermatitis has been discussed in the research. The formation of disorders of a vascular component in microcirculation in patients with perioral dermatitis has been displayed with the help of an active resonant radiometry. It records a superweak electromagnetic radio emission of biotissues refecting a condition of vascular permeability and of a transcapillary exchange of water activity.

Keywords: active radiometry, microcirculation, perioral dermatitis, water-containing mediums of an organism

Case of calcifc panniculitis

Year: 2012, volume 8 Issue: №2 Pages: 603-607
Heading: Skin Diseases Article type:
Authors: Galkina E.M., Utz S.R., Slesarenko N.A., Yepifanova A.U., Roshchepkin V.V.
Organization: Saratov State Medical University
Summary:

The study presents clinical observations of a patient with calcifying panniculitis as well as the analysis of factors that contribute to the development of this pathology. Comprehensive medical examination of the patient has been performed in order to identify the accompanying pathologies.

Keywords: pathogenesis, diagnostics, calcinosis

Effciency of acne therapy with small doses of systemic retinoids

Year: 2012, volume 8 Issue: №2 Pages: 600-603
Heading: Skin Diseases Article type: Original article
Authors: Bakulev A.L., Kravchenya S.S.
Organization: Saratov State Medical University
Summary:

The study aimed to research an effciency and safety of isotretinoin usage in small doses in patients with recurrent acne of moderate severity. Materials and methods 40 patients (18 – 27 years) with acne were examined (25 women). All of the patients have had different therapy earlier. To estimate the severity and prevalence of the disease Acne Dermatology Index (ADI) was used. All the patients were ordered isotretinoin (Roaccutane) at a standard dose of 10 mg per day for 3 months. Concentrations of triglycerides, cholesterin, ALT and AST in blood serum have been researched before and during the isotretinoin therapy. After 3-months isotretinoin monotherapy there was a prospective 6-months observation. There have been 40 healthy people examined in a control group. Results. After 3 months of isotretinoin therapy comedones, papules, pustules disappeared in most of the patients, ADI ran to 0,6±0,01 (р<0,001). Isotretinoin in the whole is tolerable, side effects were minimal. By the end of a 3-months therapy laboratory ranges (AST, ALT, triglycerides, etc.) have become comparable with control parameters. Conclusion. Small doses of isotretinoin can quickly solve the problem of an eruption in patients with acne of moderate severity, prevent a recurrence, minimize side effects risk.

Keywords: systemic retinoids, isotretinoin, acne

Topical therapy in patients with microbial eczema

Year: 2012, volume 8 Issue: №2 Pages: 596-600
Heading: Skin Diseases Article type: Original article
Authors: Bakulev A.L., Kravchenya S.S., Murashkin N.N., Igonina I.A., Yepifanova A.U., Slesarenko N.A.
Organization: Saratov State Medical University
Summary:

The study aimed to display that clinical and microbiologic research of patients with microbial eczema. The study revealed that the usage of co — formulated medication Supirocin — B was rather effcient, it promotes statistically authentic reduction of eczematous foci with pathogenic St.aureus and Str.spp. Besides, it has strong anti — infammatory effect and reduces eczematous process.

Keywords: mupirocin, microbial eczema, clinical effectiveness, betamethasone dipropionate

Possibilities of modern photography in dermatology practice

Year: 2012, volume 8 Issue: №2 Pages: 592-595
Heading: Skin Diseases Article type: Author's opinion
Authors: Alipov N.V., Reshetnikova E.M., Eremina M.G., Galkina E.M., Utz S.R.
Organization: Saratov State Medical University
Summary:

The purpose of the article was to research necessary conditions for creating high — quality images which allow to display all features of pathological process on skin more complete and authentically. That is also an integral part of modern dermatology. The usage of photographic documentation is necessary to improve students’ training, for doctor’s practical activities using the experience of the clinic, creating medical literature, and it is a unique and valuable contribution to diagnostics of dermatological diseases.

Keywords: high quality images, modern dermatology, photographic documentation

The сentenary of Saratov dermatology and venerology school (1912 – 2012)

Year: 2012, volume 8 Issue: №2 Pages: 585-592
Heading: Skin Diseases Article type:
Authors: Utz S.R., Zavyalov A.I., Slesarenko N.A., Bakulev A.L.
Organization: Saratov State Medical University
Summary:

The history of Skin and Venereal Diseases Department, Saratov State Medical University, opened in September 1912, stages of its establishment and the history of creation of scientifc school are presented in the article.

Keywords: Saratov State Medical University, department of skin and venereal diseases

Affective and cognitive disorders at men and women with discirculatory encephalopathy

Year: 2012, volume 8 Issue: №2 Pages: 570-574
Heading: Neurology Article type:
Authors: Yakovlev N.A., Abramenko Y.V.
Organization: Tver State Medical University of the Ministry of Russia
Summary:

The goal of the research was the comparative analysis of affective and cognitive disorders headache at women and men with dyscirculatory encephalopathy (DE), identify the connection of these disorders with the cerebral hemodynam-ics, neuroimaging of cinerea changes and BDNF in patients’ blood serum. 72 women (middle age 64,3±1,0) and 48 comparable in age and education men (middle age 65,0±1,2) with initiatory stages of dyscirculatory encephalopathy (DE) have been studied using comparative analysis of neuropsychological, sonographic and neuroimaging characteristics. The research revealed the predomination of cognitive impairment among men with (DE), especially attention, verbal coding and praxis disorders. Affective and insomnia disorders prevailed with women-patients. The results have shown possible links between low levels of brain-derived neurotrophic factor (BDNF) in blood plasma and the severity of depression and cognitive impairment at patients with (DE), especially at men. The received results may be important for individualization of therapeutic intervention.

Keywords: cognitive impairment, cerebral neurotrophic factor, affective disorders