Saratov JOURNAL of Medical and Scientific Research

2021, volume 17

Surgical School of Professor K.I. Myshkin (to the 100th birth anniversary)

Year: 2021, volume 17 Issue: №4 Pages: 800-802
Heading: Scientific schools, commemorative dates Article type:
Authors: Tolstokorov A.S., Duboshina Т.В., Kapralov S.V., Doroshenko S.A., Dergunova A.A.
Organization: Saratov State Medical University
Summary:

The article traces the professional path of the outstanding scientist and major surgeon Konstantin Ivanovich Mysh-kin, evaluates his scientific contribution to the development of gastrointestinal and endocrine surgery. For the first time in the research carried out under his leadership, methods of mathematical forecasting of the course and outcome of diseases were widely used. K. I. Myshkin rallied around himself a team of like-minded people who became real professionals and still manage medical institutions and directions of national scale.

Keywords: Saratov Surgical School, Saratov State Medical University n.a. V. I. Razumovsky, Konstantin Ivanovich Myshkin, endocrine surgery

Professor Susanna A. Georgieva — the founder of Saratov school of haemostasiologists

Year: 2021, volume 17 Issue: №4 Pages: 793-799
Heading: Scientific schools, commemorative dates Article type:
Authors: Puchinyan D.M., Grishin S.E., Ulyanov V.Yu., Kirichuk V.F., Korshunov G.V.
Organization: Saratov State Medical University
Summary:

The study follows the career of the prominent physiologist, educationist, and health care manager Susanna A. Georgieva, who headed the Hominal Physiology Department in Saratov Medical Institute in 1959-1982. Her active scientific efforts ensured Saratov turning into one of the USSR centers of blood clotting system researching along with Moscow, Leningrad, Kazan, Chita, Barnaul, Sverdlovsk (now Yekaterinburg), Lvov, Minsk, Frounze. Susanna A. Georgieva was a respected coagulology scientist; her achievements made her the leader of the Soviet coagulologists and brought them to Saratov to participate in the All-Russian and other large conferences. She was the founder of Saratov school of hemostasis scientists. Professor S.A. Georgieva's school made its contribution into elaboration of the following research areas: neurohumoral regulation of clotting and fibrinolysis systems, the exposure of medications to coagulatory and lytic properties of blood, clinical hemostasiology. 10 Doctors of Medical Sciences and 30 Candidates of Medical Sciences were S.A. Georgieva's school disciples.

Keywords: S.A. Georgieva, Saratov Institute of Reconstructive Surgery, Traumatology and Orthopedics, Saratov Medical Institute, Saratov Scientific Institute of Traumatology and Orthopedics

Department of Faculty Pediatrics of Saratov State Medical University: the history of a seventy-year journey

Year: 2021, volume 17 Issue: №4 Pages: 787-793
Heading: Scientific schools, commemorative dates Article type:
Authors: Goremykin V.I., Koroleva I.V., Prosova Е.Е., Sidorovich O.V., Elizarova S.Yu., Khizhnyak A.V., Kuznetsova N.A., Spivakovsky Yu.M.
Organization: Saratov State Medical University
Summary:

The article presents the history of the Department of Faculty Pediatrics at the Saratov Medical University named after V. I. Razumovsky. The path of the formation of the scientific school of pediatricians is traced from the period of the department's creation in 1949 to the present time. The main scientific directions of the department's work during this time period are highlighted.

Keywords: Department of Faculty Pediatrics, Saratov State Medical University

Assessment of the effect of liposomal forms of Xymedon and Mexidol® on the therapeutic effect of liposomal antineoplastic drugs in the experiment

Year: 2021, volume 17 Issue: №4 Pages: 780-786
Heading: Parmacology Article type: Original article
Authors: Siprov A.V., Solovyova M.A., Ageev V.P., Vashurkina I.M., Shubin D.Yu., Kechemaykina M.I.
Organization: National Research Ogarev Mordovia State University, Institute of Medicine
Summary:

Our aim is the assessment of effect of liposomal forms of Xymedon and Mexidol on antitumor and antimetastatic efficiency of liposomal combination «doxorubicin/cyclophosphamide» in experimental rats with Walker-256 carcinoma. Material and methods. Experiments were carried out on 116 Wistar female rats of weight 170-270 gm. «Doxorubicin/cyclophosphamide» combination at doses of 4/45 mg/kg, respectively, was administered as a free and liposomal forms intravenously on day 11th day of the experiment. Free and liposomal forms of Xymedon (50 and 100 mg/kg) and Mexidol (25 and 50 mg/kg) were administered intravenously during 5 days starting with day 11 of the experiment. Results. Liposomal form of Xymedon and Mexidol in the studied doses doesn't affect the growth dynamics and mass of primary tumor and doesn't prevent its metastasis suppression at the use of liposomal combination «doxorubicin/cyclophosphamide» in rats with Walker-256 carcinoma. The disappearance of large lung metastases (more than 1 mm in diameter) and predominance of small lung metastases (less than 1 mm in diameter) were observed at the combined use of liposomal Xymedon and Mexidol in the studied doses with liposomal cytostatics. Conclusion. The use of liposomal Xymedon and Mexidol together with chemotherapy by «doxorubicin/cyclophosphamide» liposomal combination doesn't reduce the therapeutic efficiency of these cytostatics and is manifested by the absence of significant changes of slowing down the growth of the primary tumor and its metastasis in rats with Walker-256 carcinoma.

Keywords: Xymedon, therapeutic efficiency, Mexidol, liposomes, doxorubicin, cyclophosphamide

Professional knowledge of pharmacists in providing pharmaceutical care to patients with diagnosed cephalgias

Year: 2021, volume 17 Issue: №4 Pages: 774-780
Heading: Parmacology Article type: Original article
Authors: Grishin A.I.
Organization: Saratov State Medical University
Summary:

Purpose: assess the level of knowledge of pharmacists in the field of pharmacotherapy of cephalgias in providing pharmaceutical care to patients with diagnosed cephalgias. Material and methods. A pharmacoepidemiological study was conducted based on a survey of 153 pharmacists and pharmacists (Saratov) using a questionnaire that includes the passport part (socio-demographic characteristics), questions about professional status, as well as questions with a detailed answer form on the topic of the study. Results. In the case of migraine, the overwhelming majority of experts' recommendations were rational (triptans, analgesics). Most of the specialists (81.7%) were unable to give any recommendations for the treatment of drug-induced headache, the remaining recommendations (18.3%) were partially correct. 79.7% of respondents could not recommend anything in the case of cluster headache, rational recommendations were given by 8.5% (oxygen, triptans). More than half of the recommendations in the case oftrigeminal neuralgia were rational (antiepileptic drugs were named). Conclusion. The low level of knowledge about the principles of treatment of certain types of headache indicates the need to improve the professional knowledge of pharmacists in this area: training of specialists and professional development will improve the quality of the pharmaceutical care.

Keywords: pharmacist, migraine, headache, cephalgia

Biological effect of pulsed current of electros hock devices

Year: 2021, volume 17 Issue: №4 Pages: 768-773
Heading: Рathophysiology Article type: Original article
Authors: Fomina T.V., Lukyanova S.N., Veselovskiy I.A.
Organization: State Research Center— Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency
Summary:

Purpose: to evaluate the bioeffects of two samples of electroshock devices (ESHU) with new, previously unexplored, electric current parameters in experiments on rabbits. Material and methods. The studies were carried out on 70 healthy rabbits weighing 2.5-3 kg (60 — experiment, 10 — control). The experiment included 6 series with different points of application of the electrodes and conditions for finding the animals. We studied the functional state of the central nervous, cardiovascular, respiratory systems, motor manifestations, and the state of the skin. The duration of exposure is 3 seconds, followed by observation during the first hour and the next 2 weeks. Results. It was found that at the time of exposure, all animals developed tonic-clonic seizures. When the electrodes were attached to the back of the neck, these convulsions turned into tonic: in fixed animals lasting 19.5±4.2 sec (sample № 1) and 20.2±2.9 sec (sample №2), in free behavior 21.9±4.5 sec (sample № 1) and 27.6±8.3 sec (sample №2). When the electrodes were applied to the chest area after exposure, psychomotor agitation arose, lasting 12.6±3.7 sec (sample №1) and 13.3±7.7 sec (sample №2). Convulsions were accompanied by changes in the respiratory and cardiovascular systems. All manifestations were transient and no longer manifested at follow-up. Conclusion. The new studied samples of ESHU caused short-term and reversible clinical and physiological changes, which were reduced to convulsive manifestations, impaired respiratory function, circulatory system, neuromuscular manifestations.

Keywords: biomedical research, electric current, electric shock devices

Endothelial dysfunction in the simulation of experimental periodontitis in white rats

Year: 2021, volume 17 Issue: №4 Pages: 765-768
Heading: Рathophysiology Article type: Original article
Authors: Savkina А.А., Lengert E.V., Ermakov A.M., Popykhova Е.В., Stepanova T.V., Ivanov A.N.
Organization: Saratov State Medical University
Summary:

The aim of the present work is to assess the dynamics of markers of endothelial dysfunction in the blood of white rats with experimental periodontitis at 3 and 5 weeks. Material and methods. The studies were carried out on 60 rats, divided into the following groups: control, which included 20 intact rats, and two comparison groups: the first — 20 animals with experimental periodontitis (3 weeks); the second — 20 animals with a ligature model of periodontitis (5 weeks). The concentration of markers of endothelial dysfunction was determined by enzyme-linked immunosorbent assay. Results. In white rats, against the background of experimental periodontitis, the concentrations of markers of inflammatory activation and markers of impaired endothelial vasomotor function significantly increase. At the 5th week of the experiment, the animals showed an increase in the concentrations of sE-selectin and VEGF — 2.5 times, asymmetric dimethylarginine and endothelin-1 was higher than the values of animals in comparison group 1 by 1.2 and 1.5 times, respectively. Conclusion. The modeling of experimental periodontitis in white rats was associated with the signs of inflammatory activation of the endothelium and its dysfunction, which was manifested by an increase in the concentration of blood of its markers at 3rd week of the experiment. In the period from the 3rd to the 5th week, despite the absence of a ligature, restoration of normal concentrations of endothelial dysfunction markers in the bloodstream were not found in animals with experimental periodontitis, and the progression of the endothelial vasomotor function disorders was observed.

Keywords: endothelial dysfunction, ligature model, parodontitis

Dynamics of the quality of life in patients after total hip arthroplasty

Year: 2021, volume 17 Issue: №4 Pages: 760-764
Heading: public health Article type: Original article
Authors: Khudoshin N.A., Abaeva O.P., Romanov S.V.
Organization: Volga District Medical Center of FMBA, First Moscow State Medical University n.a. I.M. Sechenov
Summary:

Purpose: to assess the dynamics of the quality of life of patients who underwent total hip arthroplasty. Material and methods. The authors surveyed 137 working patients aged 30 to 65 years who had undergone hip arthroplasty without complications, according to the questionnaire for assessing the quality of life SF-36 (36-ltem Short Form Health Survey) 3, 6 and 12 months after the operation. Results. The Physical Health Index of patients after total hip arthroplasty according to the SF-36 quality of life questionnaire increased on average from27.1±4.2 points before surgery to 35.9±5.3 points 3 months later (p=0.001), 43.2±4.6 points 6 months later (p<0.001), 48.2±4.5 points 12 months after surgery (p=0.041). The Mental Health Index increased from 31.9±4.5 points before total hip arthroplasty to 38.4±6.3 — 3 months later (p=0.01), 43.9±6.4 — 6 months later (p=0.03), 49.2±4.3 —12 months after treatment (p=0.04). Conclusion. The assessment of the dynamics of the quality of life of patients who underwent total hip arthroplasty revealed a statistically significant improvement in physical and mental health indicators, as well as all quality of life scales according to the SF-36 at the stages 3, 6 and 12 months after surgery.

Keywords: total hip arthroplasty, quality of life

Telemedicine in solving the problem of restricting the availability of medical care in remote areas: legal barriers of implementation and operation (review)

Year: 2021, volume 17 Issue: №4 Pages: 755-760
Heading: public health Article type: Review
Authors: Barashkov G.M., Eremina M.G., Subbotina V.G.
Organization: Saratov State Medical University
Summary:

In the healthcare system digital technology has tremendous potential. In order to identify the legal lack of regulation in the solution to the implementation and effective functioning of telemedicine, the authors analyzed a number of regulatory legal acts in the field of telemedicine, indicated legal barriers (impossibility to conduct remote diagnosis of diseases and treat patients, imperfection of legislation in the field of personal data protection, lack of legal confidentiality, lack of confidentiality when transferring, storing and exchanging information between medical professionals located in different jurisdictions, the issues of authentication of medical workers and the risks of medical responsibility of specialists, the lack of comprehensive standardization), to overcome which it is necessary to change and adopt a number of federal regulations that can provide legal support and normal functioning of telemedicine in our country. The authors analyzed 42 publications from domestic and foreign scientometric, abstract and full-text databases (eLibrary, SCOPUS, Web of Science, Medline, PubMed, Scientific Electronic Library, ciberleninka.ru, and others) for the period 2001-2021. The authors of the publications cited in the article record the legal lack of regulation in the provision of telemedicine services, which slows down its implementation and distribution.

Keywords: digital health, IT-technology, legal barriers, legal regulation, telemedicine

Quality of medical care and financial management issues (review)

Year: 2021, volume 17 Issue: №4 Pages: 751-754
Heading: public health Article type: Review
Authors: Sazanova G.Yu., Mirieva I.D., Erugina M.V., Ponomarev A.D.
Organization: Saratov State Medical University
Summary:

The review analyzes the regulatory legal acts and scientific articles related to the quality control system and financial management. Purpose: to systematize the theoretical and practical aspects of the application of financial management in organizations of the health care system to find organizational solutions aimed at improving the quality of medical care. The material of the research were publications of the electronic scientific library e-library, regulatory legal acts posted in the «Consultant» and «Garant» systems, search depth: 2006-2021, wording of queries: «financial management in health care», «financial management and quality management in healthcare», search queries by author names. A total of 26 publications were analyzed. The publications of scientists prove the significant role of the use of financial management tools (performance-based budgeting; strategic planning of the activities of medical organizations in terms of fulfilling the state assignment and target programs, monitoring the quality of financial management) in ensuring the quality of medical care, predetermining the transition to strategic financial management and the use of risk-based approach to planning the use of resources.

Keywords: financial management, health care quality, health care resources