2015, volume 11

Aim: comparison and interpretation of dermatological health-related quality of life (HRQoL) and SKINDEX-29 in patients with different subtypes of rosacea. Materials and methods. Questionnaires HRQoL and SKINDEX-29 (which is very slightly described and categorized in Russian literature) were used to question 48 patients with rosacea of 3 subtypes (the 1st, the 2nd and the 3rd). The data resulting from the study were processed statistically and tabulated. Results. Sensitivity and interchangeability SKINDEKS-29 and HRQoL were confirmed for patients with different subtypes of rosacea. A more detailed description and interpretation of SKINDEX-29 will increase the understanding of the scores obtained in patients with any dermatological pathology. The use of two questionnaires, investigating the quality of life, increases the control of psychosocial examination and the most narrowly figures details. Conclusions. Conversion of abstract SKINDEX-29 points and its clear categorization into clinically significant quantities will help to form, manage and to unite, if necessary, groups of patients, depending on the parameters of emotional, physical symptoms and psychological functioning for partnerships in the "doctor— patient" system.

Objective: to access the effectiveness of treatment methods in patients with atopic dermatitis, including every alternate day intravenous blood exposure of a low-intensity laser (LIL) with a wavelength of 365 nm (LUFOK) and 525 nm (green spectrum). Materials and methods. We observed 37 patients with atopic dermatitis (10 females and 27 males) with age ranging from 18 to 56 years (mean age 36.2) with duration of disease ranging from 17 to 54 years. In the main group in the complex therapeutic measures has been included traditional method of laser therapy with Laser therapeutic apparatus "Lazmik-VLOK" (registration certificate number RZN 2014/1410 of 02.06.2014) laser emitting heads VLOK CL-365-2 (for LUFOK) and CL-525-2 VLOK intravenous blood laser flash coverage. For VLOK we used disposable sterile radiation emitters KIVL-01 TU 9444-005-72085060-2008 Production Research Centre "Matrix" (Moscow, Russia). Results. It is shown that the combined intravenous laser LLLT treatment of blood with a wavelength of 365 nm (or 365-VLOK LUFOK) and LLLT with a wavelength of 525 nm (green spectrum VLOK-525) through 10 sessions per day in treatment of patients with atopic dermatitis allows you to get full regression of acute inflamatory symptoms of the disease like — erythema, papules, scaling, excoriations in 87.5% of patients with moderate-severe course of the disease (average index SCORAD 57,5±4,0) and reduce 3.4 times the average index SCORAD (up 21,3±4,0) in patients with severe disease course (original value 72,8±3,0) with an overall positive trend. Conclusion. The use of combined methods of physiotherapy in atopic dermatitis is justified and effective.

Aim: working out the methods of visualization of information obtained during optical coherent tomography in normal skin and in series of inflammatory disorders. Materials and Methods. OCS1300SS (made in Thorlabs, USA) was used in which the source of emission of radiation was a super-luminiscent diode with mean wavelength of 1325 nm. 12 patients with different skin conditions and 5 virtually healthy volunteers were examined with ОСТ procedure in OPD and IPD settings. High resolution USG numerical system DUB (TPM GmbH, Germany) was used for comparative USG assessment. Results. ОСТ demonstrated considerably more detailed picture of the objects scanned compared to USG investigation. Image obtained with the help of ОСТ contains vital information about sizes of macro-morphological elements, status of vascular elements and their density in different depths of the skin. Conclusion. Additional results obtained from ОСТ of the skin lesions in plane section improves attraction for ОСТ in practical dermatology.

Objective: to compare the clinical and laboratory evaluation of the efficacy of leflunomide and narrow-band medium wave UV therapy in patients with psoriasis. Material and methods. 60 patients with psoriasis. The patients were divided into 2 groups depending on the treatment. Patients of group 1 (30 patients) administered narrowband medium wave UV therapy — 20 procedures. Group 2 patients (30 persons) received leflunomide in combination with narrow-band medium wave UV-therapy. To evaluate the effectiveness of therapy studied cytokine profile. Results. Patients treated with leflunomide combined with phototherapy, marked a significant shift of the studied parameters and clearer resolution of lesions on the skin. Conclusion. The use of leflunomide in patients with psoriasis in combination with narrow-band medium wave UV therapy promotes a more definite resolution of psoriatic lesions on the skin and a significant improvement in quality of life, as well as the normalization of peripheral blood cytokine profile.

Aim: research the effectiveness of UVB 311 nm phototherapy in patients with the "escape effect" that developed in the 44th — 56th weeks of the ustekinumab use. Materials and Methods. The examination and treatment of 9 patients with extensive psoriasis vulgaris receiving ustekinumab by hypodermic injection at a dose of 45 mg if body weight of the patient not more than 100 kg, and 90 mg of body weight over than 100 kg, on the zero week, the 4th week and then every 12 weeks. Among them 6 (66,7%) men and 3 (33,3%) women aged from 28 to 65 years. All patients in the 44th — 56th weeks of ustekinumab observed effect of "escape" in connection with which he has been appointed narrowband phototherapy. Results. The combined use of ustekinumab and UVB 311 nm phototherapy in patients with "escape effect" contributes to the marked regression of clinical symptoms and allows you to control the process for long, which is confirmed by the dynamics of the index PASI, BSA and DLQI. Conclusion. In the case of the effect of "escape" in the application of biological therapy drugs (ustekinumab) possible appointment of a narrow-band medium wave phototherapy course 25-30 procedures.

Goal: the study of the effectiveness of the method for laboratory diagnostics of urogenital chlamydial infection in patients with chronic form of the disease. Material and methods. The presence of DNAof C. trachomatis was detected by PCR in either genital or extragenital (blood) sites in eighth patients (four men and four women). Results. It is established that in biological material taken from extragenital (blood) sites, C. trachomatis was detected in all patients examined (in 100% of cases), while in clinical samples obtained from genital sites, in seven patients only (87.5%). Conclusion. We found that specific chlamydial DNAcan be detected in extragenital (blood) site, despite the negative reaction in the clinical material from the genital tract of patients with genital chlamydial infection.

Goal: to examine the effectiveness of use low coherent reflectometry method for diagnostic purposes in clinical dermatology. Materials and methods. For measurements optical coherence tomography OCS1300SS (Thorlab, USA) with swiped frequency was used. 12 patients with different skin diseases were studied (psoriasis, acne, scleroderma, etc.). Results. Distinct border was detected between layers with different optical characteristics (and structure) at a depth of 1000 m to 2000 microns for majority of the samples studied. It is important to note that a good regerneration of distribution of the interference signal during transmission from one section to another and close to an exponential decay of signal with an increase in depth of probing. Conclusion. As a criterion of pathological changes,may be proposed the degree of spatial uniformity in distribution decay constant of interference signal in depth obtained with help of low coherent reflectometry (in vivo).

The article presents scientific and practical contribution of professor P. S. Grigoryev to the development of native dermatology in the first half of the 20th century.

The article presents biographical data of Professor L. G. Mamykina reflecting her scientific and practical contribution to the development of pediatrics, public health service and training of scientific staff at the Saratov Medical Institute.

The article presents the data concerning the organization of department of Normal Human Anatomy at the Saratov University and its work during the period from 1909 to 1916.