Saratov JOURNAL of Medical and Scientific Research

2015, volume 11

Pseudomonas aeruginosa exotoxin A-induced hepatotoxicity in dynamics: an animal model in white mice

Year: 2015, volume 11 Issue: №4 Pages: 526-529
Heading: Physiology and Pathophysiology Article type: Original article
Authors: Morrison A.V., Popovich V.I., Morrison V.V.
Organization: Central Scientific Research Experimental Institute 33, Saratov State Medical University
Summary:

Purpose: to study biochemical indices of peripheral blood which show organs functional changes. Material and Methods. The experiments were carried out on white mice in dynamics development of pseudomonas aeruginosa caused by intraperitoneal injection of various dosage of exotoxin A. Results. The dosage-dependent disturbances in activity of transaminases, a-HBDH, in content of proteins, lipids and cholesterol were revealed. The received data have determined the hepatotoxic effect of pseudomonas aeruginosa exotoxin A on changes of biochemical blood markers of liver function. Conclusion. The expressed hepatotoxic effect of Pseudomonas aeruginosa exotoxin A has been determined during all the phases of experiment even at sublethal toxin dose.

Keywords: exotoxin A, hepatotoxic effect, pseudomonas aeruginosa infection

Neuroamines — regulators of local processes at bone marrow autotransplantation

Year: 2015, volume 11 Issue: №4 Pages: 524-526
Heading: Physiology and Pathophysiology Article type: Original article
Authors: Vorobyova O.V.
Organization: Chuvash State University n.a. I.N. Ulyanov
Summary:

Purpose: to determine the content of neuroamines (histamine, serotonin, catecholamines) in bioamine structures of bone marrow after autotransplantation. Material and methods. Animals were injected into the tail vein of bone marrow suspension obtained from the femur of the same mouse. It was taken from the femoral bone marrow of 1 ml and placed in 2 ml of physiological saline and thoroughly stirred. 1 ml of bone marrow suspension was injected into the tail vein. Cryostat sections were treated with luminescent-histochemical methods. Results. After bone marrow autotransplantation marked changes were observed in the neurotransmitters of the bone marrow — an increasing number of granular luminescent cells decrease in the amount of granules in them, and a decrease in the number of mast cells because of their degranulation. A weak luminescence was determined in nuclei in neutrophils. Perhaps this proves the activation of the immune response. Conclusion. The bone marrow autotransplantation leads to a redistribution of the structures of the bone marrow of histamine, catecholamines and serotonin, which changes the direction of cytodifferentiation, the content of neuroamines in granular luminescent cells and mast cells (cells of autonomic regulation).

Keywords: bone marrow autotransplantation, catecholamines, granular luminescent cells, histamine, mastcells, serotonin

Anthropometric predictors of cardiovascular continuum in patients with ischemic heart disease

Year: 2015, volume 11 Issue: №4 Pages: 520-523
Heading: Macro- and Micromorphology Article type: Original article
Authors: Baleva E.S., Aleshkina O.Yu., Krom I.L.
Organization: Saratov State Medical University
Summary:

Purpose: the analysis of anthropometric characteristics of cardiovascular continuum of patients with coronary heart disease (CHD). Materials and methods. The study of the leading anthropometric predictors in the long-term prognosis of patients with coronary artery disease is based on the results of observation of 238 patients of both sexes of working age who are undergoing treatment for coronary heart disease in hospitals of Saratov. Anthropometric parameters included in the study of respondents with coronary artery disease, were measured by the common method of V. V. Bu-nak. The received data were processed by standard methods of mathematical statistics. Results. During the research of anthropometric characteristics of respondents with CHD, male, it was found that the average length of the patient's body up to 50 years is of 175,0±1,2cm, aged 51-55 years, is 172,0±0,7cm, age 55 is 175,0±0,9cm. In the process of study it is found that the dynamics of clinical, instrumental and anthropometric indicators for the period of observation is of the predictive value. Conclusion. The analysis of anthropometric predictors, including morphological characteristics and the human body type make it possible to objectify distant prognosis of patients with coronary artery disease.

Keywords: anthropometric predictors, coronary heart diseases, distant clinical prognosis

Comparative analysis of morphological and topometric parameters of lumbar spine in normal state and in degenerative-dystrophic changes

Year: 2015, volume 11 Issue: №4 Pages: 515-520
Heading: Macro- and Micromorphology Article type: Original article
Authors: Anisimova Е.А., Emkuzhev O.L., Anisimov D.l., Popryga D.V., Lukina G.A., Yakovlev N.M.
Organization: Saratov State Medical University
Summary:

Objective: to carry out comparative analysis and identify patterns of topographic variation patterns of lumbar spine in normal and degenerative changes. Material and methods. CT- and MRT-grams for men and women I (M1-22-35 years; W — 21-35 years) and II (M2-36-60 years; W2-36-55 years) periods of mature age with no signs of trauma, scoliosis and systemic diseases of the spine (n=140) and CT- and MRT-grams in patients with revealed degenerative changes in the lumbar spine degree II-III (n=120). The pictures with digital PACS system measure the height of the vertebral body, intervertebral disc height, vertical, horizontal diameter and the area of intervertebral foramen. Results. The height of the lumbar vertebral bodies normally increased from27,90±0,38mmatthe level of L, to 29,93±0,33 mm Lm, and then decreased to 24,35±0,27 mm at level L^, in osteochondrosis it is statistically significantly lower at all levels on average by 20%. The height of the intervertebral disc with osteochondrosis below at all levels by an average of 25% of its value in the range 5,27±0,19 to 6,13±0,17mm, while the normal disc height varies from 6,88±030 to 9,36±0,28mm. The area of intervertebral holes normally ranging from 103,29±5,78 to 127,99±5,92mm2, with osteochondrosis aperture area is reduced to a greater extent by decreasing the vertical diameter in comparison with the horizontal. Conclusion. For the studied parameters characteristic topographic variability has been determined. The maximum values parameters are marked at the top of the lumbar lordosis, at chest height, lumbar and lumbosacral junctions sizes are reduced. In osteochondrosis the intervertebral disc height and the height of lumbar vertebral bodies are reduced; intervertebral foramina area is also reduced to a greater extent by reducing the vertical diameter than the horizontal one.

Keywords: intervertebral disc, intervertebral foramen, lumbar spine vertebral body

The actual conception of development and pathology of fetal testes

Year: 2015, volume 11 Issue: №4 Pages: 511-514
Heading: Macro- and Micromorphology Article type: Review
Authors: Maslyakova G.N., Palatova T.V., Serkova А.А.
Organization: Saratov State Medical University
Summary:

The actual problem recently determined is concerned with the reproductive disorders in men. Male infertility results from a variety of pathological processes in the body. It is known that most anomalies of organs of reproductive system develop in the period of prenatal ontogenesis. The review provides the data on embryogenesis of fetal testes and factors that can lead to disturbances in the formation of the testes and male infertility.

Keywords: fetal testes, immunogenetic markers, male infertility

Content analysis of legal acts and the determination of the directions of optimization of palliative care in modern Russia

Year: 2015, volume 11 Issue: №4 Pages: 506-510
Heading: Health Service Organization Article type: Author's opinion
Authors: Yerugina M.V., Krom I.L, Shmerkevich А.В.
Organization: Saratov State Medical University
Summary:

The article presents the author's analysis of the normative documents of the Russian Federation necessary for providing palliative care. According to the authors regulatory — legal support of palliative medical care to the population allows to plan and to develop this kind of assistance in Russia. To ensure the availability of palliative care it is necessary to have scientific and methodological basis and to develop a general classification of the states under which the palliative care is needed and should be organized. The procedure for medical care must be brought into conformity with the mentioned above classification. The authors consider the trends of medicalisation of palliative care in Russia in the context of dysfunctional practices of the social institute of Public Health.

Keywords: medical assistance procedures, medicalization, palliative care

Modern palliative care strategy

Year: 2015, volume 11 Issue: №4 Pages: 503-506
Heading: Health Service Organization Article type: Review
Authors: Krom I.L., Yerugina M.V., Shmerkevich А.В.
Organization: Saratov State Medical University
Summary:

Changes in the structure of public health are marked in health care round the world. Patients with chronic diseases which limit their life-important needs will live longer, suffer and as a result of these factors they will need palliative care. The article presents the author's analysis of modern interpretations of palliative care from the perspective of multi-professional and multidisciplinary approach. The article considers the main trajectory of a chronic disease, defining the modern palliative care strategy. Also the article presents the main objectives and directions of palliative care. The authors state that the adopted Russian legislative documents define palliative care as palliative medical care. The medicalisation of palliative care in Russia is considered by the authors from the perspective of the dysfunctional practices of the social institute of health.

Keywords: tendency in medicalization, tasks, palliative care, interdisciplinary approach, direction, chronic diseases

Гравюры Уильяма Хогарта из коллекции Саратовского государственного художественного музея имени А. Н. Радищева, иллюстрирующие проявления сифилиса

Year: 2015, volume 11 Issue: №3 Pages: 486-491
Heading: Dermatovenerology Article type: Author's opinion
Authors: Утц С.Р., Шерстнева В.Н., Галкина Е.М., Персати М.А, Пашкова Л.В.
Organization: Saratov State Medical University, Saratov State Art Museum n.a. A.N. Radishchev
Summary:

Статья является продолжением предыдущей работы, в которой были изложены данные о связи дерматовенерологии с изобразительным искусством на примерах нескольких художественных полотен европейской и русской живописи из фонда Саратовского государственного художественного музея имени А. Н. Радищева. В настоящей работе рассматривается серия гравюр «Карьера проститутки» Уильяма Хогарта из коллекции этого музея, отражающая различные проявления сифилитической инфекции как результат пороков социально больного аристократического общества.

Keywords: syphilis, museums, medicine, engravings, art

Psychological defense mechanisms in patients with syphilis at different stages of the disease

Year: 2015, volume 11 Issue: №3 Pages: 483-486
Heading: Dermatovenerology Article type: Short message
Authors: Filonova A.V., Schneider D.A., Utz S.R.
Organization: Saratov State Medical University
Summary:

Purpose: the study of psychological defense mechanisms in patients with syphilis at different stages of the disease. Material and methods. We used questionnaire Plutchik-Kellerman-Comte "life style Index". The study involved 257 people (118 women (46%) and 139 men (54%)) aged 18 to 67 years (mean age — 23,5±8,9years). Results. In patients with primary syphilis primary mecha-protection scheme is "denying"; secondary syphilis of skin and mucus-purity membranes— "replacement"; syphilis latent early — "projection"; in patients with late syphilis — intellectualization. Thus, in patients with late forms of syphilis is dominated by more Mature mechanisms of protection (projection, rationalization). Patients with early forms use more primitive mechanisms (denial, substitution). Conclusion. The obtained data may be useful in the choice of methods of psychotherapy, the formation of patients more realistic (ADAP-tive) installations for the treatment, restoration of family and other social relations, the prevention of distress and improving the quality of life of patients.

Keywords: syphilis, psychological defense mechanisms

Work with citizens' appeals as one of the stages of implementation of the concept of the openness of information of the executive federal authorities (with Territorial body of the Federal service on surveillance in healthcare and social development of the

Year: 2015, volume 11 Issue: №3 Pages: 480-482
Heading: Dermatovenerology Article type: Short message
Authors: Tsymbal D.E., Balakina D.D.
Organization: Saratov State Medical University, Territorial body of the Federal service on surveillance in healthcare and social development of the Saratov region
Summary:

The aim: to analyze the appeals of citizens in the Territorial body of the Federal service on surveillance in healthcare and social development of the Saratov region. Material and methods. The study presents the results of work with appeals of citizens in the Territorial body of the Federal service on surveillance in healthcare and social development of the Saratov region on 2012, 2013, 2014 and the first half of 2015. We used the analytical method to make the research. Results. The study presents the percentage balance of founded and unfounded complaints, structure of the appeals of citizens. Conclusion. The study shows the high performance of the work of the Territorial body of the Federal service on surveillance in healthcare and social development of the Saratov region with the appeals of citizens and control actions of medical organizations, based on these appeals.

Keywords: control actions of medical organizations, the appeals of citizens