Saratov JOURNAL of Medical and Scientific Research

2014, volume 10

Case of successful surgical correction of combined mitral defect and chronic atrial fibrillation at the elderly patient

Year: 2014, volume 10 Issue: №1 Pages: 129-132
Heading: Surgery Article type: Case report
Authors: Bokeria L.A., Bokeria O.L., Donakonyan S.A., Sivtsev V.S.
Organization: Bakulev Center of Cardiovascular Surgery
Summary:

В статье представлены описание успешного случае процедуры cryomaze в сочетании с протезирование митрального клапана и трехстворчатого аннулопластики на пожилого пациента 71 лет. Следующие особенности клинического случая следует отметить: хроническое фибрилляции предсердий в течение 20 лет, огромный левое предсердие из 348 мл. Как известно из анамнеза, который закрылся митрального комиссуротомия было сделано 39 лет назад. Это клинический случай демонстрирует возможность успешной коррекции сложных комбинированных патологий сердца даже в пожилом возрасте. Кроме того, методика хирургической коррекции дисфункции митрального клапана в сочетании с мерцательной аритмией предусматривает обязательное устранение аритмии. Тщательный диагностика и выбор оптимального хирургического вмешательства комбинированного сердечно-сосудистых заболеваний позволяет достичь хороших результатов даже у пожилых пациентов.

Keywords: elderly people, defect of mitral valve, cryomaze procedure

Efficacy evaluation of various immunohistochemical markers in stage definition and prognosis of muscle invasive urinary bladder cancer

Year: 2014, volume 10 Issue: №1 Pages: 124-128
Heading: Urology Article type: Original article
Authors: Ponukalin A.N., Maslyakova G.N., Tsmokalyuk E.N.
Organization: Saratov State Medical University
Summary:

Objective: to carry out the comparative efficacy evaluation of various immunohistochemical markers in stage definition and prognosis of muscle-invasive urinary bladder cancer. Material and methods. Surgical material has included 80 patients with urinary bladder neoplasms. Clinical, histological, immunohistochemical and statistical methods of research has been used. Results. The immunohistochemical investigation has showed that only 4 markers from the 12 (Ki-67, рбЗ, p53 и EGFR) make possible to determine the stage of urinary bladder cancer and the disease prognosis. Conclusion. The proliferative activity of marker Ki-67 can be used as an auxiliary marker in the choice of volume of surgical treatment, which could predict an unfavorable outcome of disease in 81,2% of cases.

Keywords: Ki-67, muscle invasive bladder cancer, stage definition and prognosis

Microelement content of bone tissue in transosseous osteosynthesis by II-izarov technique in high-altitude destinations (experimental research

Year: 2014, volume 10 Issue: №1 Pages: 119-123
Heading: Traumatology and Orthopedics Article type: Original article
Authors: Erokhin A.N., Isakov B.D., Nakoskin A.N.
Organization: Bishkek State Medical Academy, Russian Ilizarov Scientific Center «Restorative Traumatology and Orthopaedics»
Summary:

Aim: To study the redistribution of microelements in bone tissue in osteosynthesis in high-altitude destinations. Material and Methods. The study was performed on 72 mongrel dogs of both sexes aged 1-3 years, weighing 10—15 kg. 32 dogs have been experienced the extended leg in lowlands destinations, another group of 32 animals have been experienced elongation produced in high-altitude destinations. The control group consisted of 8 healthy dogs of low mountain areas. The standard technique of surgery has been used in the research. Microelement composition has been studied by atomic absorption spectrophotometer AAS-1 N (Germany) in the long bones and the distraction regenerate. Shapiro —Wilk test was applied to analyze the normality. The data evaluation has been done by Student's t-test for unpaired samples. Results. Calcium and microelement imbalance has been obtained during transosseous osteosynthesis in high-altitude destinations, which causes functional changes in the musculoskeletal system, with similar clinical picture of Kashin — Beck. In the conditions of high-altitude destinations elongation of bones causes changes in microelements in the distraction regenerate. Conclusion. During distraction osteosynthesis in high-altitude destinations phase changes of microelements have been formed in the bone regenerate, which prognoses physiologically the formation of a false joint.

Keywords: distraction osteosynthesis, high-altitude destinations, microelements

X-ray, anatomical and biomechanical features in patients with developmental hip dislocation

Year: 2014, volume 10 Issue: №1 Pages: 114-119
Heading: Traumatology and Orthopedics Article type: Original article
Authors: Yusupov K.S., Anisimova Е.А., Pavlenko N.N., Letov A.S., Zaychev V.A., Emkyzhev O.L., Zotkin V.V., Markov D.A.
Organization: Saratov State Medical University
Summary:

The Pupose: to analyze X-ray, anatomical and biomechanical features in patients with developmental hip dislocation. Material and Methods. The study included 73 patients (57 women and 16 men) with the developmental hip dislocation at the age of 31 to 76 years. The clinical method, X-ray, gait analysis and visual analogue scale VAS, McGill inquiry. Results. The comparative analysis of X-ray, anatomic and biomechanical features in patients with different severity of developmental hip dislocation. Conclusion. Features of the functional status of patients with different severity of developmental hip dislocation enable to predict the tactics of surgical treatment and individual rehabilitation program.

Keywords: biomechanical gait analysis, developmental dislocation of the hip, total endoprosthesis, X-ray parameters

Content of vascular endothelial growth factor in blood serum and gastric juice in children with chronic inflammatory diseases of stomach and duodenum

Year: 2014, volume 10 Issue: №1 Pages: 110-113
Heading: Pediatrics Article type: Original article
Authors: Zavyalova O.V., Spivakovsky У.М., Zakharova N.B., Lukina O.A., Sirotkin E.A.
Organization: Saratov State Medical University
Summary:

The aim: to assess the levels of vascular endothelial growth factor (VEGF) in children with chronic inflammatory diseases of stomach and duodenum. Material and methods. 67 children with chronic inflammatory diseases of gastroduo-denal zone have been investigated. The substrate of the study included the serum and portion of gastric content. The data obtained were compared with a group of healthy children. Results. Maximum high content of VEGF was identified in children with duodenal ulcer. Conclusion. The content of this indicator depended on the Helicobacter pylori infection.

Keywords: children, chronic gastroduodenitis, Helicobacter pylori, vascular endothelial growth factor

Evaluation of knowledge of breastfeeding mothers before and after the maternity school

Year: 2014, volume 10 Issue: №1 Pages: 108-110
Heading: Pediatrics Article type: Original article
Authors: Belyaeva N.A., Panina O.S., Chernenkov Yu.V.
Organization: Saratov State Medical University
Summary:

Objective: to evaluate the level of knowledge of surveyed women about breastfeeding before and after the maternity school. Material and methods. The anonymous survey of 300 women on breastfeeding has been conducted. The questionnaire consisted of two parts: theoretical and practical. The questionnaire has been filled in on the 3d day after the childbirth (before the maternity course). On the 4th day after the childbirth mothers have been provided with the main issues on breastfeeding and practical recommendations. Results. The questionnaire survey has showed the low level of knowledge of mothers about breastfeeding before the maternity school. The level of knowledge after the school has increased in 2.5 times. The knowledge in practical aspects has increased in 5.2 times. Conclusion. The courses on breastfeeding contribute to the educational status of mothers concerning the questions of correct lactation dominant.

Keywords: breast-feeding, educational maternity school, newborn, survey

Ultrasound Diagnostics of Liver Cancer

Year: 2014, volume 10 Issue: №1 Pages: 103-107
Heading: Oncology Article type: Review
Authors: Schukina О.Е.
Organization: Saratov State Medical University
Summary:

The literature review presents opportunities of the contemporary ultrasound technologies in diagnostics of liver cancer; diagnostic criteria have been determined; the accuracy degree of the ultrasound method in grey-scale and Doppler imaging have been also revealed.

Keywords: liver cancer, ultrasound diagnostics

Critical problem of clinical pathogenicity of Helicobacter pylori in gastroen-terology

Year: 2014, volume 10 Issue: №1 Pages: 96-102
Heading: Clinical Pharmacology Article type: Review
Authors: Belova O.L., Bogoslovskaya S.I., Belova I.M.
Organization: Saratov State Medical University
Summary:

In discussional article argue unfounded of infectious hypothesis of the pathogenesis of ulceral disease of gastric and duodenum.

Keywords: gastritis, Helicobacter pylori, pathogenesis

Pregnancy associated plasma protein-A in acute coronary pathology.

Year: 2014, volume 10 Issue: №1 Pages: 92-95
Heading: Сardiology Article type: Original article
Authors: Sapozhnikov A.N., Razin V.A., Chernysheva E.M., Gimaev R.Kh., Kajumova G.Kh., Mazurova O.V., Akhmetshina D.I.
Organization: Ulyanovsk State University
Summary:

The aim: to study pregnancy associated plasma protein A as a potential marker of myocardial necrosis with acute coronary syndrome. Material and methods. The rates of PPPP-A and insulin-like growth factor 1 were determined in 24 patients with acute myocardial infarction, in 18 patients with unstable angina and in the control group as well. Results. The rates of PPPP-A and ILGF-1 are accurately higher in the groups with acute coronary pathology in comparison to the patients with no ischemia. Conclusions. PPPP-A proves to be a marker of ischemia and/ or injury and could be used as a diagnostic predictor of an unstable atherosclerotic plaque in acute coronary development.

Keywords: progressive angina pectoris, pregnancy associated plasma protein-A, myocardial infarction

Influence of low-intensity electromagnetic fields on endothelial function in patients with chronic heart failure

Year: 2014, volume 10 Issue: №1 Pages: 86-92
Heading: Сardiology Article type: Original article
Authors: Bokeria O.L., Kuular A.M.
Organization: Bakulev Center of Cardiovascular Surgery, Moscow State Medical Stomatological University n.a. A. I. Evdokimov
Summary:

Objective: to evaluate the influence of low-intensity electromagnetic fields on endogenous bioresonance therapy on the level of asymmetric dimethylarginine in blood, as well as on the parameters of microcirculation in the assessment of endothelial function in patients with chronic heart failure. Material and Methods. The basic group included 40 patients with chronic heart failure (NYHA II): 17 female and 23 male patients. The average age of the patients was 56,4±10 years. The control group consisted of healthy volunteers (20 patients, including 10 women, 10 men aged 31 ±5 years). Assessment of vasomotor state of the endothelium microcirculation was carried out with the help of laser Dopplerflow-metry on the apparatus LAKK-TEST (T) («Lazma», Russia). After the procedure endogenous bioresonance therapy was held. The intervention by low-intensity electromagnetic fields was carried out with the help of a hardware-software complex IMEDIS-EXPERT mode of endogenous bioresonance therapy for 15 minutes. Vasomotor endothelial function of microcirculation was evaluated. The concentration of an inhibitor of nitric oxide synthases, asymmetric dimethylar-ginine in blood before and after the exposure to the intervention by low-intensity electromagnetic fields was studied. Results. After the endogenous bioresonance therapy the microcirculation M parameter in the main group, on the background of iontophoresis with acetylcholine counted in average6,13±4,7 PF units. After iontophoresis with nitroprusside it was 5,9±3,8 PF units. In the control group the rate of myogenic oscillation amplitude (Am) amounted in average 0,75±0,13 Hz, in the main group it was 0,68±0,26 Hz. Reduction of myogenic tone in the control group was statistically significant (p

Keywords: endothelial dysfunction, endothelium-dependent and endothelium-independent vasodilatation, low-intensive laser radiation