Saratov JOURNAL of Medical and Scientific Research

Clinical effectiveness of prophylactic treatment of women at risk for the formation of vascular retinal pathology after preeclampsia

Year: 2020, volume 16 Issue: №1 Pages: 220-223
Heading: Ophtalmology Article type: Original article
Authors: Kolenko O.V., Sorokin E.L., Fil A.A., Khodzhaev N.S., Chizhova G.V.
Organization: S. Fedorov Eye Microsurgery Federal State Institution, Postgraduate Institute for Public Health Workers, Far Eastern Federal University
Summary:

The purpose of the study is to investigate the clinical effectiveness of prophylactic treatment of women who have previously undergone preeclampsia and are a part of the risk group for the formation of vascular retinal pathology. Material and Methods. The main group consisted of 40 women aged 24 to 43. The selection criterion was presence of a risk of vascular retinal pathology formation. Women of the main group were prescribed periodic courses of preventive treatment for a period of time of 3-4.5 years. The comparison group consisted of 51 women, who underwent preeclampsia, and also had a risk of forming vascular retinal pathology and did not receive preventive treatment. Results. Systematic conduct of preventive treatment courses with antiplatelet agents and antioxidants to women who have undergone preeclampsia and are at risk of vascular retinal pathology formation have been effective. Conclusion. Frequency of vascular retinal pathology formation in the main group decreased to 15% against 34% in the comparison group (p<0.05).

Bibliography:
1. Kolenko OV, Sorokin EL, Khodzhaev NS, et al. Creation of an algorithm for a prediction of vascular retinal pathology in women after suffered pre-eclampsia and an evaluation of its efficiency. Fyodorov Journal of Ophthalmic Surgery 2019; (4): 24-31.
2. Kolenko OV, Sorokin EL, Khodzhaev NS, et al. Regularities of macular blood flow in pregnant women with preeclampsia in the III trimester and after delivery, risk factors for development of vascular pathology of posterior segment of the eye. Pacific Medical Journal 2019; (2): 25-8.
3. Sorokin EL, Kolenko OV, Khodzhaev NS, et al. The choroidal blood flow of eye during pregnancy and in postnatal period in women with preeclampsia, clinical part for predicting risk of vascular pathology of posterior segment of the eye. Pacific Medical Journal 2019; (2): 43-6.
4. Powe СЕ, Levine RJ, Karumanchi SA. Preeclampsia, a disease of the maternal endothelium: The role of antiangiogenic factors and implications for later cardiovascular disease. Circulation 2011; 123 (24): 2856-69. DOI: 10.1161/circulationaha. 109.853127.
5. Vaidiviezo C, Garovic VD. Preeclampsia and hypertensive disease in pregnancy: their contributions to cardiovascular risk. Clinical Cardiology 2012; 35 (3): 160-5. DOI: 10.1002/clc. 21965.
6. Kiseleva Nl. Endothelial dysfunction in preeclampsia: pathogenesis, diagnosis and treatment. Protection of Motherhood and Childhood 2006; (1): 49-56.
7. Korokin MV, Pashin EN, Bobrakov KE, et al. Endothelioprotective, cardioprotective and coronary effects of 3-oxipiridin derivatives. Man and His Health: Kursk Scientific and Practical Bulletin 2009; (4): 11-9.
8. Suchkov IA. Correction of endothelial dysfunction: current status of the problem (literature review). I. P. Pavlov Russian Medical and Biological Bulletin 2012; (4): 151-7.
9. Tyurenkov IN, Voronkov AV, Slietsans AA, et al. Antioxidant therapy of endothelial dysfunction. Reviews on Clinical Pharmacology and Drug Therapy 2013; 11 (1): 14-25.
10. Gavrilova NA, Tischenko ОЕ. The impact of sulodexide on the endothelial functional state in patients with diabetes mellitus and diabetic retinopathy. Diabetes Mellitus 2011; (2): 66-8.
11.Gazizova IR. Modern possibilities for correction of disturbances of cellular energetics in ophthalmology. Kazan Medical Journal 2012; 93 (4): 668-71.
12. Shilkin GA, Kaledintsev MN, Yukhanova OA. Experience of Tanakan usage (EGb 761) in ophthalmology: Literary review. Russian Journal of Clinical Ophthalmology 2008; 9 (2): 63-6.

AttachmentSize
2020_01-2_220-223.pdf784.4 KB

No votes yet