Saratov JOURNAL of Medical and Scientific Research

Far Eastern Federal University

Comparative analysis of the content of biochemical markers of endothelial dysfunction in women with preeclampsia and in the development of vascular retinal pathology

Year: 2020, volume 16 Issue: №2 Pages: 668-671
Heading: Ophtalmology Article type: Original article
Authors: Fil А.А., Sorokin E.L., Kolenko O.V.
Organization: Far Eastern Federal University, Postgraduate Institute for Public Health Workers, S. Fyodorov Eye Microsurgery Federal State Institution
Summary:

Purpose: to study the level of markers of endothelial dysfunction (ED) in women with preeclampsia and with the development of retinal vein occlusions. Material and Methods. The main group was formed by 62 pregnant women with preeclampsia (124 eyes). Their age ranged from 22 to 43 years (30±6.9 years). The 1st comparison group was formed by 20 women with a physiological course of pregnancy, a comparable age and duration of pregnancy. The 2nd comparison group included 16 non-pregnant women with occlusions of the superior temporal branches of the central retinal vein (16 eyes). As a control group, 20 somatically healthy, non-pregnant women (40 eyes) were selected. Markers of ED were studied twice in the main and 1st comparison groups (III trimester of pregnancy and 6-8 months after delivery). In the control and 2nd comparison groups — once. Results. The levels of von Willebrand factor and endothe-lin-1, which are known to be the main markers of ED development, turned out to be high in women of the main group (109.3±33.2% and 2.69±1.49 ng/ml respectively), and in the 2nd comparison group (110.3±29.2% and 2.6±0.4 ng/ml respectively). Conclusion. Increased endothelin-1 in the tear fluid and von Willebrand factor in blood plasma in women with preeclampsia, as well as maintaining their high levels after 6-8 months, after childbirth may indicate the presence of generalized ED, which is a favorable background for the development of vascular retinal pathology in the remote postpartum period.

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Clinical effectiveness of prophylactic treatment of women at risk for the formation of vascular retinal pathology after preeclampsia

Year: 2020, volume 16 Issue: №1 Pages: 220-223
Heading: Ophtalmology Article type: Original article
Authors: Kolenko O.V., Sorokin E.L., Fil A.A., Khodzhaev N.S., Chizhova G.V.
Organization: S. Fedorov Eye Microsurgery Federal State Institution, Postgraduate Institute for Public Health Workers, Far Eastern Federal University
Summary:

The purpose of the study is to investigate the clinical effectiveness of prophylactic treatment of women who have previously undergone preeclampsia and are a part of the risk group for the formation of vascular retinal pathology. Material and Methods. The main group consisted of 40 women aged 24 to 43. The selection criterion was presence of a risk of vascular retinal pathology formation. Women of the main group were prescribed periodic courses of preventive treatment for a period of time of 3-4.5 years. The comparison group consisted of 51 women, who underwent preeclampsia, and also had a risk of forming vascular retinal pathology and did not receive preventive treatment. Results. Systematic conduct of preventive treatment courses with antiplatelet agents and antioxidants to women who have undergone preeclampsia and are at risk of vascular retinal pathology formation have been effective. Conclusion. Frequency of vascular retinal pathology formation in the main group decreased to 15% against 34% in the comparison group (p<0.05).

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Academic performance, motivation and quality of life associated with the health of senior students of medical and humanitarian specialties

Year: 2019, volume 15 Issue: №4 Pages: 897-904
Heading: public health Article type: Original article
Authors: Kuznetsov V.V., Bayramov R.A., Smirnov E.A., Kosilova E.K., Kosilov K.V., Karashchuk E.M., Zayko A.A.
Organization: Pacific State Medical University, Far Eastern Federal University
Summary:

Objective: a comparative analysis of the relationship of quality of life associated with health with academic performance and motivation to learn from students of humanities and medical specialties of senior courses. Material and Methods. The study was conducted at the School of Biomedicine of the Far Eastern Federal University and Pacific State University. The sample size is 516 students (51% girls). 272 (52.7%) students studied medical specialties; 244 (47.3%) — humanities. For questioning students used a comprehensive questionnaire self-assessment of socio-economic and medical status of a student of the University (Pozdeyeva, 2008), the questionnaire MOS SF-36. Academic motivation was assessed on the scale of Т. О Gordeeva and O. A. Sychev (2014); academic performance — according to the semester statistical reports of the relevant departments and faculties. Results. The total indicators of physical and mental health in the assessment of quality of life associated with health among students of medical and humanitarian specialties did not differ significantly, although the assessment of their quality of life by humanitarians was slightly higher (67.1/64.1; p>0.05). It was found that strong relationships are characteristic of variables: learning conditions (r=0.89, p<0.05); academic performance and motivation to study (r=0.75, p<0.05; r=0.79, p<0.05); the presence of bad habits (r=0.77, p<0.05); self-assessment of physical health (r=0.67, p<0.05). Conclusion. The quality of life associated with health at students of medical and humanitarian specialties is interconnected by motivation to study and progress, and also a number of variables of the social and economic status and morbidity.

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