2015, volume 11

Цель: оценить воздействие однократного внутривенного введения покрытых полиэтиленгликолем золотых наностержней на молекулярные маркеры межклеточного взаимодействия и показатели перекисного окисления в сыворотке крови четырех групп крыс: интактных, с аллоксановым диабетом, с перевитым раком печени; с перевитым раком печени на фоне аллоксанового диабета. Материалы и методы. Активность перекисного окисления липидов оценивалась по показателям гидроперекисей липидов, малонового диальдегида и молекул средней массы с использованием общепринятых спектрофотометрических методов, исследования молекулярных маркеров — фактора некроза опухоли TNF-a, инсулиноподобного фактора роста IGF-1, васкулоэн-дотелиального фактора роста VEGF-C проводились в сыворотке крови методом иммуноферментного анализа. Результаты. Выявлено, что при однократном внутривенном введении золотых наностержней не происходит значительного изменения количества маркеров межклеточного взаимодействия и показателей перекисного окисления липидов. в периферической крови. Заключение. Полученные результаты позволяют рекомендовать использование покрытых полиэтиленгликолем золотых наностержней в экспериментальной онкологии.

Stroke and cerebral infarction in particularly are important medical and social problems. The article describes the historical changes of legal acts regulating medical care for patients with stroke and observes recent researches dealing with the law enforcement in this sphere. Content analysis revealed the lack of correspondence between the legal framework and clinical guidelines for cerebral infarction. Particular attention is paid to the low level of scientific research results concerned with the stroke outpatient medical care.

Purpose: the study of trends in overall morbidity and primary hypertension in the Saratov region over the period from 2002 to 2013. Materials and methods. The official statistics Ministry of Health and the Federal State Statistics Service were used, which is processed using analytical and statistical methods. Results. The article has been providing the analysis of total and primary arterial hypertension morbidity of the population of the Saratov region, which is in accordance with the degree of the Government of the Russian Federation from December 1, 2004, N 715 to the group of socially significant diseases. During the period from 2002 to 2013 in the Saratov region, as well as in the Russian Federation in Volga Federal district, the tendency of growth of the overall incidence and the decrease in the primary incidence of arterial hypertension. Conclusion. The dynamics of incidence of hypertension suggests the need for careful analysis and optimization of medical care for patients with hypertension

Objective: to identify ways to use ICT in some areas of work of the territorial authority of Roszdravnadzor. Materials and Methods. We used a questionnaire survey of 50 employees of territorial bodies of Roszdravnadzor, 50 employees of the licensing bodies of the three subjects of the Russian Federation (the Republic of Tatarstan, Samara and Saratov region), 50 license applicants in the territory of the Samara region (a total of 150 respondents). For statistical processing of the results we used the criterion ("Chi-square") K. Pearson. Results. The analysis of the survey results reliably indicates a broad support for the subjects of licensing relations the introduction of modern ICT in the work of the relevant public authority. Conclusion. The study results of the views of the staff of the licensing authorities and applicants of licenses for medical activities on introduction of modern information and communication technologies in the work of the licensing authority have been presented. As possible methods it has been suggested the use of special (special programmes) and general (content site) groups.

Purpose: analysis of the present state of the system of professional training of nursing personnel and of the need for nursing personnel at the regional level. Methods. The indicators of availability of nursing staff in the Saratov region and the parameters of activity of nursing professional education institutions in the region have been analyzed. Results. Problems of nursing personnel provision of the healthcare system and the main trends of training of nursing personnel were identified. Conclusion. Optimization of personnel maintenance of healthcare and nursing personnel training system is possible by creating conditions for the professional realization of nursing personnel and adaptation of young professionals at the workplace.

Purpose: an assessment of efficiency of complex treatment of periodontitis at women in a period of postmenopause with the use of zoledronic acid. Material and methods. Examination and treatment of 90 patients with a chronic generalized periodontitis against post-menopausal osteoporosis has been conducted. Material is processed statistically. Results. Application of preparations of zoledronic acid in complex treatment of system osteoporosis and periodontitis allows to reduce the frequency of recurrence of periodontal disease and to improve indicators of bone remodeling. Conclusion. In conclusion it is worth while determining that zoledronic acid in complex therapy of periodontitis is an effective method of drug correction of a mineral exchange before periodontological surgery.

Purpose: to develop fundamental basis of science based healthcare management in social and economic instability. Public health state (1998-2008, selected region) was characterized by cardiovascular health parameters (Code IX, ICD-10). Systematic review was performed according to PRISMA guidelines. Dynamic characteristics of major cardiovascular diseases in social and economic instability considered as a cause of a population system destabilization were reconstructed. Conclusion. Fundamentals of science based healthcare management in social and economic instability include long- and short-term prognosis of public health characteristics as the result of multifactor external influences on cardiovascular diseases prevalence.

The purpose of research is an integrative analysis and justification of the priorities of the quality of life optimization with patients with coronary heart disease. Material and Methods. Some sociological and statistical methods were used in this study. Results. The article presents the results of the study of quality of life of patients with ischemic heart disease, using a questionnaire WHOQOL-100. The study established the statistical dependence of the quality of life of patients with coronary heart disease on the quality of medical care, which is considered by the authors as an obligate modifiable predictor of quality of life of these patients. Conclusion. Medical care is considered according to the research as the obligate modified predictor of quality of life of the patients suffering from coronary heart disease. Statistical dependence of indicators of quality of life of sick IBS on medical care is established during research. Correction of standards of medical care acts as one of conditions of optimization of quality of life of sick coronary heart disease.

The goal is to analyze the main sources of health maintenance among elderly people who continue working after retirement. Material and methods. Analysis of the main sources of health maintenance among elderly people is based on the results of sociological research by means of semi-structured interview, conducted in 2014 in Saratov city. The sample included 8 respondents aged 55-65 years who continue working after their retirement. Results. The main sources of health maintenance among working pensioners include such preventive measures as moderate physical exercise, rational nutrition, folk medicine, hardening, and regular medical examinations. It was revealed that in the case of self-prevention of chronic diseases worsening elderly persons rely on previous doctors' prescriptions, drugs instructions, and medical literature. Conclusion. The data obtained in this research allow to make the conclusion that along with demand for preventive measures of health maintenance among working pensioners, there is an expansion of self-medication practice. This fact could be explained by a decrease of confidence in primary health care services, low availability of paid medical services.

Confidentiality as the component of an interpersonal "patient — medical practitioner" contact formation can be considered as a corner stone of geriatric practice. Major psychological pitfalls of geriatric practice have been reviewed. The main issue of the paper is psychological substantiation of treatment and prevention of elderly.