Saratov JOURNAL of Medical and Scientific Research

№1, 2014, volume 10

The assessment of bronchial asthma pharmacotherapy effectiveness on the background correction of magnesium deficiency in children

Year: 2014, volume 10 Issue: №1 Pages: 211-214
Heading: Parmacology Article type: Original article
Authors: Shishimorov I.N., Perminov А.А., Nefedov I.V.
Organization: Volgograd State Medical University

Aim: to evaluate the efficacy of pharmacotherapy of bronchial asthma in children with concomitant correction of magnesium deficiency. Material and Methods. A 12-week, prospective, randomized, open, comparative, parallel-group, which was included in the 50 children with uncontrolled and partially controlled atopic asthma and laboratory-confirmed magnesium deficiency. For the groups 1 and 2 it was assigned basic therapy of asthma in accordance with the recommendations of GINA (2011). In the group 1 it had been additionally performed concomitant correction of magnesium deficiency of Magnesium B6 Forte. There had been evaluated the effectiveness of a drug therapy for 12 weeks on the achieved level of asthma control, the frequency of exacerbations, the number of asymptomatic days. Dynamics of the severity of allergic inflammation was assessed by monthly monitoring of levels of nitric oxide in exhaled air (FeNO). Results. After 12 weeks of treatment, the magnesium content in erythrocytes in group 1 (1.79 (1,68-1,89) mmol / L) increased by 15.7% and was statistically significant (p

Keywords: asthma, asthma control, children, magnesium deficiency

Organizational aspects of conducting of bioequivalence study

Year: 2014, volume 10 Issue: №1 Pages: 203-210
Heading: Parmacology Article type: Original article
Authors: Khokhlov A.L., Kagramanyan I.N., Lileeva E.G., Sinitsina O.A., Miroshnikov A.E., Shitov L.N.
Organization: Ministry of Health of the Russian Federation, Yaroslavl State Medical Academy

Aim: to evaluate the organizational aspects of conducting bioequivalence study in Russia on the example of one of the clinical centers, Yaroslavl. Material and methods. On the basis of the Municipal Autonomous institution of health care of the Yaroslavl region Clinical hospital №2 (CH, clinical base of the Department of clinical pharmacology of YSMA) was held 93 bioequivalence studies and pharmacokinetics in the period from 2011 to 2014, of which 15 studies of foreign sponsors and 78 of domestic producers. Result.: The studies involved 48 volunteers of both sexes from the database of clinical center CH №2. There were 698 females (48.6%) and 739 males (51.4%). The average age of the volunteers was 26,37 years. In each study there were from 18 to 103 volunteers, depending on the design of the research Protocol. At the same time Russian studies ranged about 18-24 volunteers, about 30-103 volunteers abroad. The number of doubles in domestic studies ranged from 2 to 6 persons, and foreign — from 6 to 12 people. 10-15% from the whole number of subjects were not included into the study. Conclusion. In Russia bioequivalence of medicines for more than ten years is the main requirement of medico-biological control generic drugs. Regardless of the manufacturer to the generic drugs are exactly the same as the original drugs, must meet the following requirements: quality efficiency and safety. In connection with the increase in recent years of bioequivalence studies of medicines, require close monitoring of the quality of these studies on the territory of the Russian Federation.

Keywords: conducting bioequivalence, pharmakokinetics

Pharmacometrics as an instrument of clinical pharmacology for optimization of drugs dosing regimens during pregnancy

Year: 2014, volume 10 Issue: №1 Pages: 199-203
Heading: Parmacology Article type: Review
Authors: Reshetko O.V., Lutsevich К.А.
Organization: Saratov State Medical University

Changes in maternal physiology and metabolic during pregnancy influence pharmacokinetics and illustrate that standard adult dosing is likely to be incorrect during pregnancy. Different pharmacometric approaches are available for design and analysis of clinical studies during pregnancy. Physiologically-based pharmacokinetic (PBPK) model could be used to evaluate different dosing regimens for pregnant women and serves in predicting drug exposure and response at the personal level.

Keywords: pharmacometric, pharmakokinetics, pregnancy

Pharmacoeconomic efficiency of the exhaled nitric oxide monitoring for the purpose of personalized basic therapy for children with atopic asthma

Year: 2014, volume 10 Issue: №1 Pages: 196-199
Heading: Parmacology Article type: Original article
Authors: Petrov V.I., Shishimorov I.N., Magnitskaya O.V., Ponomareva Ju.V.
Organization: Volgograd State Medical University

effectiveness of basic therapy for atopic asthma in children. Material and Methods. A 24-week, prospective, comparative, randomized, open-label study in parallel groups was performed. There were included 70 children with uncontrolled atopic asthma with high FeNO (FeNO>50ppb). There were evaluated the comparative efficacy of selection of basic therapy by using monthly monitoring of FeNO and criteria of asthma control in accordance with the recommendations of GINA (2011). Results. The cost / effective ratio (CER) for achievement of one permanent 12 week-control after 24 weeks of therapy in group of monitoring FeNO was 11433,26 rubles, which was 40% lower, than the CER in the comparison group (18382,99 rubles). Conclusion. The using of FeNO monitoring for a personalized correction of basic therapy in children with uncontrolled atopic asthma can reduce the cost of treatment and is also economically viable.

Keywords: pharmacoeconomics, nitric oxide in exhaled air, children, asthma

Pharmacoepidemiological analysis of the drugs used for secondary prevention of brain infarction on dispensary stage

Year: 2014, volume 10 Issue: №1 Pages: 189-195
Heading: Parmacology Article type: Original article
Authors: Miheyeva N.V., Reshetko O.V., Furman N.V.
Organization: Saratov Institute of Cardiology, Russia, Saratov State Medical University

Aim. The secondary prevention of cerebral infarction on dispensary stage to current clinical guidelines was analyzed. Adherence of patients to prescribe medications was evaluated. Material and methods. 106 patients of hospital neurologic department with brain infarction were included in prospective pharmacoepidemiological study of the drugs used for secondary prevention of brain infarction on dispensary stage since 1 January 2009 to 31 December 2009. Duration of outpatient observation was 3 years. Results. All of the patients were of 64,9 ± 10,3 years old. Hypertension was diagnosed in 102 of them (96.2%), atrial fibrillation — in 33 (31.1%) patients. 39 (36.8%) patients died during 3 years after discharge from the hospital. ACE inhibitors/angiotensin II receptor antagonist were prescribed for 83 (78.3%) patients, antiplatelet- 76 (71,7%), statins — 16 (15,1%) patients in discharge from hospital. Warfarin was prescribed only for 1 (3.05%) patient with atrial fibrillation and ischemic stroke.consumption of drugs with evidence efficiency were diminished already after one year of observation in outpatient clinics. Conclusion.Therapy for secondary stroke prevention is not fully comply with current clinical guidelines


The treatment of H.pylori infected adults and children in Volgograd: pharmaco-epidemilological investigation

Year: 2014, volume 10 Issue: №1 Pages: 185-188
Heading: Parmacology Article type: Original article
Authors: Magnitskaya O.V., Ponomareva Ju.V., Ryazanova A.Ju., Yefimova A.A., Chechetkina Je.M., Idelbaeva E.S., Bukina N.Ju., Volodina L.A., Kartashova T.R., Gorjushkina A.A..
Organization: Volgograd State Medical University

This article represents results of pharmacoepidemiological research of H.pylori eradication treatment of adults and children in Volgograd. The aim was to determine H. pylori pharmacotherapy stereotypes and compare with international experts' recommendations. Material and Methods. There were analyzed CRFs of 94 adults and 132 children with H.pylori associated diseases in Volgograd region. Results. There were identified mistakes of treatment regimes and eradication control principles. Conclusion. The treatment of H.pylori infected adults and children in Volgograd does not match to international experts' recommendations.

Keywords: adults, children, eradication treatment, Helicobacter pylori, pharmacoepidemiology

Features of pharmacotherapy and clinical course of atrial fibrillation in patients with type 2 diabetes in real clinical practice. Saratov Journal of Medical Scientific

Year: 2014, volume 10 Issue: №1 Pages: 178-185
Heading: Parmacology Article type: Original article
Authors: Graifer l.V., Reshetko O.V., Furman N.V., Dolotovskaya P.V.
Organization: Saratov Institute of Cardiology, Russia, Saratov State Medical University

The aim of the study was to investigate the clinical status of patients with atrial fibrillation (AF) and diabetes mellitus (DM) type 2 and to identify differences in the treatment of AF, conducted in the cardiology departments of multidisci-plinary teaching hospitals of the Saratov city. Materials and methods. A comparative retrospective analysis of 1041 pharmacoepidemiological solid history of patients with AF who were hospitalized in emergency, and in the planning department of cardiology of 2 multidisciplinary teaching hospitals of the Saratov city consecutively in a calendar year on the AF, recorded on an electrocardiogram. Results. Among all patients with AF, patients with DM accounted for 20.2%. Among them were women, they were younger, they developed fibrillation at a younger age, they differed more severe structural heart disease, among which was significantly greater with myocardial infarction, nearly all had symptoms of heart failure. Patients with DM performed less frequently cardioversion, and to monitor heart rate often preferred a combination of beta-blockers and digoxin. 100% of patients with DM had a higher risk of thromboembolic complications (91.9% without diabetes) in both groups, oral anticoagulants (OAC) prescribed often enough. Conclusion. DM was diagnosed in every fifth patient with AF, especially among women and patients with persistent AF and is associated with the presence of more severe organic heart disease compared with patients without DM. All patients on the background DM was a high risk of thromboembolic complications, i.e. OAC must be assigned in 100% of cases, but in the surveyed hospitals OAC were appointed only in 23% of cases.

Keywords: atrial fibrillation , diabetes mellitus, pharmacotherapy

Community-acquired pneumonia: biomarkers of inflammation and Omega-3 polyunsaturated fatty acids

Year: 2014, volume 10 Issue: №1 Pages: 173-178
Heading: Parmacology Article type: Review
Authors: Burbello A.T., Gaikovaya L.B., Pokladova M.V., Komok M.V., Kostyitsyna M.A.
Organization: North-West State Medical University n.a. I.I. Mechnikov, Department of Neuropathology Assistant Professor, Candidate of Medical Science

Based on the published data the role of inflammation in development of pneumonia has been discussed. The role of inflammatory mediators and laboratory markers for diagnostics of community acquired pneumonia is evaluated, as well as prognostic role of different biomarkers of inflammation, available for clinical laboratories, but not widely used in daily clinical practice. Influence of Omega-3 polyunsaturated fatty acids on inflammatory processes and possibilities to use them in the treatment of community acquired pneumonia is also discussed in the study.

Keywords: biomarkers of inflammation, community acquired pneumonia, inflammatory, Omega-3 polyunsaturated fatty acids

The effect of Mexidol on magnesium-calcium balance and endothelial dysfunction in operational stress

Year: 2014, volume 10 Issue: №1 Pages: 167-170
Heading: Рharmacology Article type:
Authors: Baturin V.A., Fisher V.V., Sergeev S.A., Yatsuk I.V.
Organization: Stavropol State Medical University

The aim of the study: to study the effect of mexidol content of ionized calcium and magnesium in erythrocytes and the number of circulating endothelial cells in patients undergoing surgery in the maxillofacial area. Material and methods. The intracellular concentration of calcium and magnesium was measured before the operation, in one, three and five days after the surgery with the help of cytochemical method. Mexidol (100mg) was administered intravenously as a single addition to the standard premedication. Results. After surgery, the intracellular calcium and magnesium content increased. After 24 hours, the magnesium level began to decline, and the calcium content in erythrocytes continued to grow. On day 5, the magnesium concentration in erythrocytes decreased below the initial level, and calcium levels remained significantly elevated. Number of endothelial cells in the blood increased immediately after surgery and magnesium-calcium balance and limits endothelial dysfunction. Mexidol continued growing, reaching a peak on day 5 after surgery. When using mexidol decreased levels of calcium and magnesium levels help prevent falls on the 5th day after surgery, decreased the number of circulating endothelial cells. Conclusion. Mexidol prevents postoperative magnesium violation.

Keywords: endothelium cells, intracellular calcium, intracellular magnesium, mexidol, operational stress

History review on blood transfusion in Saratov

Year: 2014, volume 10 Issue: №1 Pages: 153-156
Heading: Scientific schools Article type: Short message
Authors: Sadchikov D.V., Kuligin A.V., Osipova O.V., Averyanov E.G., Volkova E.V.
Organization: Saratov Regional Station of Blood Transfusion, Saratov State Medical University

The article presents the history review on the development of blood transfusion in Saratov, the organization and activity of regional station of blood transfusion during the war and the post-war years.

Keywords: blood donor center, blood transfusion, Blood Transfusion Department, Saratov blood transfusion station of the Central institute of blood transfusion