Saratov JOURNAL of Medical and Scientific Research

The assessment of bronchial asthma pharmacotherapy effectiveness on the background correction of magnesium deficiency in children

Year: 2014, volume 10 Issue: №1 Pages: 211-214
Heading: Parmacology Article type: Original article
Authors: Shishimorov I.N., Perminov А.А., Nefedov I.V.
Organization: Volgograd State Medical University

Aim: to evaluate the efficacy of pharmacotherapy of bronchial asthma in children with concomitant correction of magnesium deficiency. Material and Methods. A 12-week, prospective, randomized, open, comparative, parallel-group, which was included in the 50 children with uncontrolled and partially controlled atopic asthma and laboratory-confirmed magnesium deficiency. For the groups 1 and 2 it was assigned basic therapy of asthma in accordance with the recommendations of GINA (2011). In the group 1 it had been additionally performed concomitant correction of magnesium deficiency of Magnesium B6 Forte. There had been evaluated the effectiveness of a drug therapy for 12 weeks on the achieved level of asthma control, the frequency of exacerbations, the number of asymptomatic days. Dynamics of the severity of allergic inflammation was assessed by monthly monitoring of levels of nitric oxide in exhaled air (FeNO). Results. After 12 weeks of treatment, the magnesium content in erythrocytes in group 1 (1.79 (1,68-1,89) mmol / L) increased by 15.7% and was statistically significant (p

1. The national program "Bronchial asthma at children: strategy of treatment and prevention". Moscow: Original-maket, 2008; 184 p.; 2. Thomas М, Gruffydd-Jones К, Stonham С, et al. Assessing asthma control in routine clinical practice: use of the Royal College of Physicians '3 questions'. Prim Care Respir J 2009;18 (2): 83-8; 3. Global Strategy for Asthma Management and Prevention. Global Initiative for Asthma (GINA) 2011.; 4. Liang RY, Wu W, Huang J, et al. Magnesium Affects the Cytokine Secretion of CD4 (+) T Lymphocytes in Acute Asthma. J Asthma 2012; 49 (10): 1012-5; 5. Mazur A, Maier JA, Rock E, Gueux E, et al. Magnesium and the inflammatory response: potential physiopathological implications. Arch Biochem Biophys 2007; 458 (1): 48-56; 6. Nowacki W, Malpuech-Brugere C, Rock E, et al. High-magnesium concentration and cytokine production in human whole blood model. Magnes Res 2009; 22 (2): 93-6; 7. Bede O, Nagy D, Suranyi A, et al. Effects of magnesium supplementation on the glutathione redox system in atopic asthmatic children. Inflamm Res 2008; 57 (6): 279-86; 8. Dominguez LJ, Barbagallo M, Di Lorenzo G, et al. Bronchial reactivity and intracellular magnesium: a possible mechanism for the bronchodilating effects of magnesium in asthma. Clin Sci (Lond)1998;95(2): 137-42; 9. Hijazi N, Abalkhail B, Seaton A. Diet and childhood asthma in a society in transition: a study in urban and rural Saudi Arabia. Thorax 2000; 55 (9): 775-779; 10. SoutarA, Seaton A, Brown K. Bronchial reactivity and dietary antioxidants. Thorax 1997, 52 (2): 166-170; 11. Bede O, Suranyi A, Pinter K, et al. Urinary magnesium excretion in asthmatic children receiving magnesium supplementation: a randomized, placebo-controlled, double-blind study. Magnes Res 2003; 16 (4): 262-70; 12. Schenk P, Vonbank K, Schnack B, et al. Intravenous magnesium sulfate for bronchial hyperreactivity: a randomized, controlled, double-blind study. Clin Pharmacol Ther 2001; 69 (5): 365-71; 13. Mohammed S, Goodacre S. Intravenous and nebulised magnesium sulphate for acute asthma: systematic review and meta-analysis. Emerg Med J. 2007; 24 (12): 823-30.

2014_01-01_211-214.pdf444.16 KB

No votes yet