№1, 2014, volume 10

The goal is to study gender features of rheological properties of blood in patients with chronic generalized periodontitis (CGP) from mild to moderate severity. Material and Methods. 80 patients (43.8% male) with CGP aged 42±5 years have been studied. 41 patients (43.9% male) experienced mild severity of CGP, and 39 patients (43.6% male) experienced moderate severity. 40 healthy adults (50% male), aged 31±7 years, have been included into the study. Plasma viscosity on shear rate values 300 sec1 to 5 sec1, and rheological features of erythrocytes (aggregation and deformation) have been evaluated. Results. In healthy women and women with mild severity of CGP, plasma viscosity was lower than in the similar group of men. The rheological features of erythrocytes have not gender differences among healthy adults and patients with mild CGP. Increased severity of CGP has been associated with increased plasma viscosity and rheological features of erythrocytes, particularly in men. Conclusion. Plasma viscosity differs in men and women (childbearing age) (healthy subjects and patients with CGP). In women, severity of pathological changes of plasma viscosity and rheological features of erythrocytes have been determined to be lower than in men.

The aim: to study the variability of morphometric parameters of the head of men of 21-35 years old, with orthognathic and direct occlusion and identify their differences. Material and Methods. Cephalometry performed in 93 men aged 21 to 35 years from the Saratov region. Distribution groups conducted for the type of physiological occlusion: orthognathic (n=61) and direct (n=32). To determine the parameters used cephalometric anthropometric standard set of tools. On the head cephalometric points were determined between which measured morphometric parameters of the cranial and facial departments, as well as parameters of soft tissue structures. Results. In men with physiological occlusion parameters having statistically significant differences in orthognathic and direct bite were identified: head length, morphological face height, the height of nasal and maxillary division, mandibular body height, width of the face, the angular width of the face. Average values of these parameters are more prevalent in men who have a direct bite.
Conclusion. The data obtained should be considered during orthodontic and orthopaedic treatment, with lectures and practical training in the departments and faculties of the human anatomy with the dental profile.

In order to establish the relationship between the timing of fetal obliteration of communication and expression remodeling of the heart chambers, as one of the possible causative factors of SIDS, the selected material has been based on macromorphometric study. Material included 43 hearts from infants who died of SIDS. The control group consisted of 48 hearts of children suddenly dead from aspiration of gastric contents and infectious disease. The methods composed a macroscopic examination of the heart by the method of separate weighing of the complex morphometric studies, histological examination (used the following stains: hematoxylin and eosin, picrofuchsin by Van Gieson, Nissl's stain), immunohistochemical method using markers of neurofilament. The results revealed that in children who died of SIDS, obliteration of the fetal communication occurs essentially in the late period —to the age of 8 months, and the mass of the left and right ventricles of the heart exceeds the age limit of normal due to the prevalence of ventricular muscle mass and hypertrophy of cardiomyocytes. In all parts of the heart subendocardial fibrosis in the ventricles — pronounced interstitial fibrosis has been observed. In the interatrial septum at the location at the oval window morphometric study resulted in significant predominance area percentage of connective tissue in relation to the muscle tissue. On histological sections elements of the nervous tissue — randomly arranged nerve ganglia with degenerative changes and nerve fibers were identified. Conclusion. Finally, it should be noted that the growth of cardiosclerosis in all parts of the heart in newborns and infants, who died suddenly from SIDS, extends the terms of obliteration of fetal communications, and degenerative changes in the nerve ganglia that lead to the disturbance of supply and distribution of nerve impulses that pass through them. These factors contribute to the development of hemodynamic disturbances and may be important in the development of sudden death in children.

Currently the departments of quality control of blood centers evaluate the suitability for clinical use of erythrocyte-containing solutions indirectly by routine methods of the determination of hemoglobin concentration, hematocrit level, or hemolysis at the end of the period of storing. These methods can not directly characterize the state of membranes of preserved erythrocytes. The aim of the work is to study the changes of elasticity and surface potential of membranes of red blood cells of erythrocyte-containing solutions in storage for 35 days. Material and Methods. Two series of dry cytological preparations (smears) of erythrocytes have been investigated. The first group consisted of 8 samples of erythrocyte-containing solutions prepared on the day of preservation, and the second group included 20 samples prepared after the long term storage for 35 days at t=+4°C. Blood was stored in bags of «Baxter» company (USA) conserving with «CPDA-1». For atomic force microscopy five typical erythrocytes were selected and their elasticity was measured at 9 points of the membrane of each erythrocyte. Total number of measurements was 1296. Results. Average value of Young's modulus of the first group of samples was 1,81±0,02 (M±m) KPa. The second group showed 3,22±0,02 KPa statistically higher (p

Purpose: the complete analysis of the morphological parameters of the thyroid gland in various forms of thyroid pathology by methods of mathematical modeling. Material and Methods. Histologically examined samples of operating thyroid glands of 199 patients of both sexes aged 21 to 74 years, were treated surgically. Experimental data were studied by factorial and discriminant analysis. Results. When the factor analysis of 60 experimental parameters were identified 14 major factors that indicate 14 main trends in the dynamics of the structure of the thyroid gland due to an increase in severity of pathological processes. Discriminant analysis showed that the study of quantitative structure of the thyroid gland there may be cases of erroneous inclusion in the theoretical option groups, however, the study of the entire set of indicators observed a 100% correct distribution of cases by groups of pathology. Conclusion. As a result, the factor of the original system of 60 morphological parameters of thyroid pathology in various forms has been minimized to 14 new uncorrelated parameters (main factors), reflecting changes in the morphology of the basic laws of the pathology of the gland. As a result of the discriminant analysis of morphological parameters of the thyroid gland in different types of its pathology the importance of semi-quantitative parameters of thyroid structure has been revealed.

Purpose: to reveal features of bone structures correlation of acetabulum and femoral components of a hip joint. Material and methods. The sizes of acetabulum, pelvis and proximal metaepiphysis of femur have been determined on 98 sets of pelvis and femurs and 120 KT-grams of adults. Results. Sexual and bilateral distinctions, correlation of bone structures of acetabulum, proximal metaepiphysis and femur have been revealed. Conclusion. The received values of the main morphometric parameters of bone structures of hip joint and pelvis and their correlation develop the database of clinical anatomy of hip joint.

Regulations and publications on the provision of quality health care for patients with diseases of the circulatory system of the native scientists have been studied. The majority of the issues concerns the disorganization of health care standards: the uneven distribution of diagnostic resources mostly in the hospitals and preventive health care organizations. The proposed ways to improve the patient care have been analyzed.

The process of aging is caused by the early development of chronic complications and diversity of morphological and functional changes of organs and systems. Therefore the provision of preventive and curative care of this category of citizens has significant clinical and organizational features. Aim: to identify the main problems of medical care for the elderly and to examine the medical care. Material and Methods. 250 physicians of various specialties of medical institutions of the Saratov region on health care of the elderly in out-patient clinics have been surveyed by specially designed questionnaires. The state of receiving care in out-patient clinics has been studied among the elderly and the senile patients (n=568) by questioning. Results: The majority of physicians recognize the importance of the problem of increasing the quality of care for the elderly. The development of assistance of gerontological profile and the need for optimization of rendering out-patient care for this category of population in the central clinics and regional medical institutions. Conclusion. The level of satisfaction of elderly patients depends on the age characteristics, gender, health and social status and the place of residence of the study group.

The Objective: research of regularities of adaptation of graduates of medical schools to conditions of independent professional activity and justification of the directions of optimization of management by this process. Material and Methods. Object of research included functioning of system of adaptation of graduates of medical schools to conditions of independent professional activity. Are carried out: The study of reports of the Saratov region for 2006-2012, documentation of 16 treatment-and-prophylactic medical organizations and 84 responses on graduates of Saratov State Medical University n.a. V. I. Razumovsky; anonymous retrospective questioning of 164 doctors after professional retraining at the faculty of professional development; expert questionnaire of 15 persons of the faculty of organizational chairs have been carried out. Results. In the work "complex adaptation factor"; dynamics of level of social and psychological, psychophysiological, organizational and professional indicators of adaptation of graduates to conditions of independent professional activity; the characteristic of "lagging behind" doctors; purposes of management of adaptation, importance of stages of its organizational support have been established. The ways to evaluate the success of individual adaptation and management of this process have been worked out, which are designed on the basis of the corresponding authorized optimization technology. Conclusion. Results of the conducted research allowed to expand idea of adaptation of graduates of medical schools to conditions of independent professional activity and to solve a number of applied problems of its optimization.

The aim of the research is to determine the main patterns of activity of in-patient medical organizations according to the resource provision of medical and diagnostic process. Material and methods. 20 medical organizations, including regional organizations, central regional hospitals, Saratov municipal health care organizations, non-private and private medical organizations have been surveyed. The survey of 60 chemists of hospital pharmacies has been conducted. Results. The analysis of the survey has showed the resource provision of medical and diagnostic process by medical products, the degree of technological provision in hospitals of various types and stated the main problems of activity on resource provision. Conclusion. It has been found out that the current medical provision with medical products is connected with the action of considerable number of objective and subjective factors and it defines the efficiency of medical social activity.