№1, 2014, volume 10

Представлены биографические данные о профессоре О. С. Глозмане, отражающие его вклад в развитие патологической физиологии и кафедры в Саратовском медицинском университете.

The aim of the article is to discuss the main stages of formation and development of Department of Health Service, Public Health and Medical Law of Saratov State Medical University. Scientific and practical contribution to the development of the national health over the years has been determined. The data on the current scientific and educational activities of the department have been highlighted.

This article analyzes the first experience in the implementation into the pedagogical process of one of the methods of active training — role playing. The need for intensification of medical education process is linked primarily to the rapid increase in the volume required to provide students with information and the lack of training time. The analysis showed that the game significantly increases the level of students' knowledge, but require substantial modernization of the educational process.

The article is devoted to the innovations in the higher medical education. Particular attention in this sphere is paid to the detailed analysis of the subject as a mechanism of cognition and psycho-emotional aspect. It should be noticed that the development of the university education demands the integration of functional systems to study the general medicine and the art of healing. In conclusion it has been found out that the new methodological approach is necessary to bring the teacher closer to the subject particularly to integrate the relation of the opposites.

Despite the success of therapeutic treatment of peptic ulcer and the introduction of endoscopic technologies, the problem of peptic ulcer hemorrhage remains valid. A large number of publications in foreign literature are dedicated to epidemiology and prevention of bleeding, evaluation of modern tactics and search for new methods of treatment. The works relating to organization of aid to patients with peptic ulcer bleeding are of particular interest. According to the recent data not all clinics even in economically developed countries manage to follow the recommendations of an international consensus-2010 for non-variceal bleeding treatment of upper gastrointestinal tract. Among the causes of non-compliance of international recommendations there are subjective and objective factors, the understanding of which can significantly affect the optimization of aid to patients with peptic ulcer bleeding.

В статье представлены описание успешного случае процедуры cryomaze в сочетании с протезирование митрального клапана и трехстворчатого аннулопластики на пожилого пациента 71 лет. Следующие особенности клинического случая следует отметить: хроническое фибрилляции предсердий в течение 20 лет, огромный левое предсердие из 348 мл. Как известно из анамнеза, который закрылся митрального комиссуротомия было сделано 39 лет назад. Это клинический случай демонстрирует возможность успешной коррекции сложных комбинированных патологий сердца даже в пожилом возрасте. Кроме того, методика хирургической коррекции дисфункции митрального клапана в сочетании с мерцательной аритмией предусматривает обязательное устранение аритмии. Тщательный диагностика и выбор оптимального хирургического вмешательства комбинированного сердечно-сосудистых заболеваний позволяет достичь хороших результатов даже у пожилых пациентов.

Objective: to carry out the comparative efficacy evaluation of various immunohistochemical markers in stage definition and prognosis of muscle-invasive urinary bladder cancer. Material and methods. Surgical material has included 80 patients with urinary bladder neoplasms. Clinical, histological, immunohistochemical and statistical methods of research has been used. Results. The immunohistochemical investigation has showed that only 4 markers from the 12 (Ki-67, рбЗ, p53 и EGFR) make possible to determine the stage of urinary bladder cancer and the disease prognosis. Conclusion. The proliferative activity of marker Ki-67 can be used as an auxiliary marker in the choice of volume of surgical treatment, which could predict an unfavorable outcome of disease in 81,2% of cases.

Aim: To study the redistribution of microelements in bone tissue in osteosynthesis in high-altitude destinations. Material and Methods. The study was performed on 72 mongrel dogs of both sexes aged 1-3 years, weighing 10—15 kg. 32 dogs have been experienced the extended leg in lowlands destinations, another group of 32 animals have been experienced elongation produced in high-altitude destinations. The control group consisted of 8 healthy dogs of low mountain areas. The standard technique of surgery has been used in the research. Microelement composition has been studied by atomic absorption spectrophotometer AAS-1 N (Germany) in the long bones and the distraction regenerate. Shapiro —Wilk test was applied to analyze the normality. The data evaluation has been done by Student's t-test for unpaired samples. Results. Calcium and microelement imbalance has been obtained during transosseous osteosynthesis in high-altitude destinations, which causes functional changes in the musculoskeletal system, with similar clinical picture of Kashin — Beck. In the conditions of high-altitude destinations elongation of bones causes changes in microelements in the distraction regenerate. Conclusion. During distraction osteosynthesis in high-altitude destinations phase changes of microelements have been formed in the bone regenerate, which prognoses physiologically the formation of a false joint.

The Pupose: to analyze X-ray, anatomical and biomechanical features in patients with developmental hip dislocation. Material and Methods. The study included 73 patients (57 women and 16 men) with the developmental hip dislocation at the age of 31 to 76 years. The clinical method, X-ray, gait analysis and visual analogue scale VAS, McGill inquiry. Results. The comparative analysis of X-ray, anatomic and biomechanical features in patients with different severity of developmental hip dislocation. Conclusion. Features of the functional status of patients with different severity of developmental hip dislocation enable to predict the tactics of surgical treatment and individual rehabilitation program.

The aim: to assess the levels of vascular endothelial growth factor (VEGF) in children with chronic inflammatory diseases of stomach and duodenum. Material and methods. 67 children with chronic inflammatory diseases of gastroduo-denal zone have been investigated. The substrate of the study included the serum and portion of gastric content. The data obtained were compared with a group of healthy children. Results. Maximum high content of VEGF was identified in children with duodenal ulcer. Conclusion. The content of this indicator depended on the Helicobacter pylori infection.