Saratov JOURNAL of Medical and Scientific Research

Regenerative capabilities of the skin

Year: 2018, volume 14 Issue: №4 Pages: 738-739
Heading: Dermatovenerology Article type: Author's opinion
Authors: Eremina M.G., Eremin A.V., Eldesbaeva Ya.S., Drozdova S.B., Roshchepkina E.M., Chumachenko Yu.V.
Organization: Saratov State Medical University

The skin is the largest organ of the human body and has many functions. Stem cells of the epidermis and hair follicles are necessary for homeostasis and skin regeneration, which leads to the restoration of the integrity and function of the damaged tissue. Currently, we are actively searching for the best therapeutic strategies to restore the barrier function of the skin. Stem cells are recognized as potential candidates for the treatment of numerous skin pathologies. Therapeutic strategies of modern medicine require an understanding of the potential uses of stem cells for treating skin diseases.

1 Hsu YC, Li L, Fuchs E. Emerging interactions between skin stem cells and their niches. Nat Med 2014; (8): 847-56
2 Gonzales KA, Fuchs E. Skin and Its Regenerative Powers: An Alliance between Stem Cells and Their Niche. Developmental Cell 2017; 43 (November 20): 387-401
3 Ojeh N, Pastar I, Tomic-Canic M, Stojadinovic O. Stem Cells in Skin Regeneration, Wound Healing, and Their Clinical Applications. Int J Mol Sci 2015; (16): 25476-501
4 Robbins PB, Lin Q, Goodnough JB, et al. In vivo restoration of laminin 5 p3 expression and function in junctional epi-dermolysis bullosa. Proc Natl Acad Sci USA 2001; 98, 5193-8
5 Mavilio F, Pellegrini G, Ferrari S, et al. Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells. Nat Med 2006; 12, 1397-402
6 Toyoshima KE., Asakawa K, Ishibashi N, et al. Fully functional hair follicle regeneration through the of stem cells and their niches. Nat Commun 2012; 3: 784
7 Dunnwald M, Tomanek-Chalkley A, Alexandrunas D, et al. Isolating a pure population of epidermal stem cells for use in tissue engineering. Exp Dermatol 2001; (10): 45-54
8 Wong VW, Levi B, Rajadas J, et al. Stem Cell Niches for Skin Regeneration. International Journal of Biomaterials, published online. DOI: 10.1155/2012/926059 (June 2012)
9 Keyes BE, Brice E, et al. Nfatd orchestrates aging in hair follicle stem cells. Proc Natl Acad Sci USA 2013; 110 (51): E4950-9. 10 Chen CC, PJ Murray, Jiang TX, et al. Regenerative hair waves in aging mice and extra-follicular modulators follista-tin, Dkk1, and Sfrp4. J Invest Dermatol, published online, 2014 DOI: 10.1038/jid.2014.139.

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