Saratov JOURNAL of Medical and Scientific Research

Saratov State Medical University

www.sgmu.ru

Computer analysis of corneal aberrations in relation to the tasks of laser surgery of the anterior segment of the eye

Year: 2019, volume 15 Issue: №2 Pages: 425-428
Heading: Ophtalmology Article type: Original article
Authors: Bakutkin V.V., Bakutkin I.V., Zelenov V.A., Nugaeva N.R.
Organization: International Consulting, Audit and Education Academy, Saratov State Medical University
Summary:

Purpose: development of a method for computer analysis of corneal aberrations as applied to the tasks of laser surgery of the anterior segment of the eye. Material and Methods. As a result of mathematical modeling, an algorithm has been developed that is implemented as a computer program for selecting individual parameters of laser radiation depending on the optical characteristics of the cornea. Results. For astigmatism, it has been proposed to consider the topographic zones of the optical center of the cornea, 3.5 mm in diameter, and peripheral meridional zones. Aberrations at the periphery of the cornea increase by 10 %. At 1 and 2 stages of keratoconus, the rate of aberrations rises 2–3 times. In the third stage of keratoconus, in some cases keratometry and keratotopography is technically impossible. With pterygium 2 and 3 degrees, laser surgery in the peripheral zone of the cornea is impossible. Conclusion. Improving the efciency of laser operations is provided primarily by optimizing the impact parameters on the tissues of the anterior segment of the eye. The data on the types of corneal aberrations for various diseases, which indicate the need to change the parameters of laser exposure. The developed diagnostic algorithms are implemented as a computer program and allow you to optimize the parameters of laser irradiation of eye tissue.

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To live saving lives

Year: 2019, volume 15 Issue: №2 Pages: 392-395
Heading: Scientific schools and memorable dates Article type: Short message
Authors: Lazarenko Ya.S., Nikitina V.V.
Organization: Saratov State Medical University
Summary:

The article provides the data on the activity of the Saratov doctors at the front and in the rear during the Great Patriotic War and their contribution to the development of medicine, devotion of a profession and the sense of responsibility for people»s lives.

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In memory of veterans of the Great Patriotic War who chaired the department of biology of Saratov State Medical University

Year: 2019, volume 15 Issue: №2 Pages: 389-392
Heading: Scientific schools and memorable dates Article type: Short message
Authors: Durnova N.A., Andronova T.A., Gladilin Yu.A.
Organization: Saratov State Medical University
Summary:

The present work highlights the facts about two scientists who in diferent years worked as chairs of the department of general biology at the Saratov Medical Institute and who participated in the Great Patriotic War — professor Alexander Stepanovich Konstantinov, doctor of biological sciences, and associate professor Alexander Evgenievich Sholpo.

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In memory of veterans of the Great Patriotic War who chaired the department of biology of Saratov State Medical University

Year: 2019, volume 15 Issue: №2 Pages: 389-392
Heading: Scientific schools and memorable dates Article type: Short message
Authors: Durnova N.A., Andronova T.A., Gladilin Yu.A.
Organization: Saratov State Medical University
Summary:

The present work highlights the facts about two scientists who in diferent years worked as chairs of the department of general biology at the Saratov Medical Institute and who participated in the Great Patriotic War — professor Alexander Stepanovich Konstantinov, doctor of biological sciences, and associate professor Alexander Evgenievich Sholpo.

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Activity of the museum of history of Saratov State Medical University name after V. I. Razumovsky as an important factor of educational process and familiarization with cultural heritage

Year: 2019, volume 15 Issue: №2 Pages: 383-389
Heading: Scientific schools and memorable dates Article type: Short message
Authors: Bugaeva I.O., Erugina M.V., Ishchenko Yu.V., Shumilova L.N.
Organization: Saratov State Medical University, Volga Region Cooperative Institute (Branch) of Russian University of Cooperation
Summary:

The diverse aspects of activity of the museum of history of Saratov State Medical University are considered. The value of the museum in educational and scientifc processes is shown. The integrating function of the museum and also the mechanism of impact of its activity on familiarizing of students with cultural heritage, formation of competences and moral and esthetic installations are analyzed. On the basis of practical activities of the museum necessity of its integration with various structural divisions of the university is revealed.

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The relation of carbohydrate metabolism disorders and markers of endothelial dysfunction in animals with absolute insulin defciency at biostimulation by autotransplantation of the skin fap

Year: 2019, volume 15 Issue: №2 Pages: 379-38
Heading: Physiology and Pathophysiology Article type: Original article
Authors: Popykhova E.B., Ivanov A.N., Stepanova T.V., Pronina E.A., Lagutina D.D.
Organization: Saratov State Medical University
Summary:

The purpose of this work is to study the relationship of carbohydrate metabolism disorders and markers of endo-thelial dysfunction in animals with absolute insulin defciency at biostimulation by autotransplantation of the skin fap. Material and Methods. The study was conducted on 60 male white outbred rats, which were divided into: an intact control group, a two comparative and an experimental group. In animals of the comparison group, alloxan diabetes mellitus (DM) was caused, in rats from the experimental group, an autotransplantation of the skin fap was performed against the background of developed alloxan diabetes. The levels of glycated hemoglobin (HbA1c), glucose, C-reactive protein (CRP) and vascular endothelial growth factor (VEGF) were determined. Results. Autotransplantation of the skin fap causes a normalization of the glycemic profle in animals of the experimental group, and also reduces subclinical infammation caused by hyperglycemia and stabilizes the expression of VEGF.Diabetes causes an increase in HbA1c by 69 % and CRP by 11 %, while аutotransplantation of the skin fap leads to a decrease in the concentration of HbA1c by 28 % and CRP by 7 %. Conclusion. Autotransplantation of the skin fap reduces the risk of microcirculatory disorders due to hyperglycemia and chronic subclinical infammation.

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Endothelial dysfunction in burn injury

Year: 2019, volume 15 Issue: №2 Pages: 377-379
Heading: Physiology and Pathophysiology Article type: Original article
Authors: Morrison V.V., Bozhedomov A.Yu., Morrison A.V.
Organization: Russian State Medical University, Saratov State Medical University
Summary:

Objective: to estimate the level of markers of endothelial dysfunction in burn injury of various severities. Material and Methods. 57 patients were included in the study. The level of vascular endothelial growth factor (VEGF), endothe-lin, nitric oxide metabolites (NO), and the amount of circulating desquamated endothelial cells were determined in the dynamics of burn injury development. Results. In burn injury there was an increased amount of endothelial dysfunction markers in blood, which is highly expressed on the 7-15th day. Moreover on the 7th day in case of severe and extremely severe burn injury the level of VEGF was increased over 50 times while the amount of endothelin, nitric oxide metabolites and circulating desquamated endothelial cells becomes higher in 3–5 times. Conclusion. The research outcomes have proved the damage of endothelial lining in burn injury.

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Composite nanomaterials on the basis of magnetic nanoparticles for theranostic application

Year: 2019, volume 15 Issue: №2 Pages: 368-371
Heading: Physiology and Pathophysiology Article type: Review
Authors: Bucharskaya A.B.
Organization: Saratov State Medical University
Summary:

Literature review is devoted to the use of composite nanomaterials based on magnetic nanoparticles for the diagnosis and treatment of various diseases.

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Intense light deprivation as a factor in stress disorders of behavioral reactions and cognitive functions in the experiment

Year: 2019, volume 15 Issue: №2 Pages: 363-368
Heading: Physiology and Pathophysiology Article type: Original article
Authors: Antipova O.N., Ivanov A.N., Zlobina O.V., Kirichuk V.F., Surovtseva K.A., Ankina V.D., Bondar G.D., Zenkina T.M., Polyukova M.V.
Organization: Saratov State Medical University
Summary:

Objective: to study the efect of light desynchronosis on behavioral reactions and cognitive functions of white male rats. Material and Methods. The study was conducted on 36 intact non-pedigree white male rats, which were divided into 2 groups: experimental and control. Animals were exposed to artifcial illumination 24 hours a day provided by the fuorescent lamp of 60 kW capacity. The same animals of the experimental group on the 10th, 21st and 30th days were tested in the installations «Dark-light camera» and «Open feld». Results. On the 10th day of intensive light deprivation, the indicators refecting the research-orientation activity reached the maximum values, which indicated the development of stress damage to the animal organism. On the 21st day of the experiment, the

Keywords: pneumocysts
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Optimization of the process of creating models of human blood vessels

Year: 2019, volume 15 Issue: №2 Pages: 353-357
Heading: Human anatomy Article type: Original article
Authors: Dol A.V., Ivanov D.V., Fomkina O.A.
Organization: Saratov National Research University n.a. N. G. Chernyshevsky, Saratov State Medical University
Summary:

Objective: to optimize the process of biomechanical modeling of blood vessels on the example of creating models of the arterial circle of the brain. Material and Methods. Biomechanical modeling requires the creation of a patient-oriented three-dimensional solid-state geometric model of the object under study. This problem can be solved by computer data processing (CT) or magnetic resonance (MRI) tomography. A program that implements the construction of blood vessel contours on individual sections of MRI in semi-automatic mode. These contours are exported as saved curves in a specifc format to SolidWorks, where they are used to create three-dimensional models of blood vessels. The models obtained in this way take into account the personal characteristics of the structure of the vascular bed of a particular patient and can be used in the process of biomechanical modeling. Results. The results of the program implementation of the recursive frontal growth method for processing two- dimensional slices of tomograms are presented. Conclusion. The developed software allows semi- automatic loading of DICOM images and obtaining fat sections of vessels on their basis, as well as transferring them for further processing into computer-aided design systems.

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