Saratov JOURNAL of Medical and Scientific Research

Saratov State Medical University

www.sgmu.ru

Sergey Ivanovich Spasokukotsky as a founder of Department of Hospital Surgery of Saratov State Medical University named after V.I. Razumovsky (to the 150th birth anniversary)

Year: 2020, volume 16 Issue: №2 Pages: 538-541
Heading: Scientific schools and memorable dates Article type:
Authors: Tsarev О.А., Kovalenko Yu.V., Zavyalov A.I., Titova D.A.
Organization: Saratov State Medical University
Summary:

The article presents the bibliographic data about academician S. I. Spasokukotsky. It demonstrates his contribution to the development of surgery, healthcare management and training of academic and teaching staff at Department of Hospital Surgery of Saratov Medical University.

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Contribution of professor V.I. Rubin to the development of clinical biochemistry

Year: 2020, volume 16 Issue: №2 Pages: 534-538
Heading: Scientific schools and memorable dates Article type:
Authors: Zakharova N.B., Borodulin V.В., Nikitina V.V., Bobyleva E.V., Ivanenko I.L., Kovalenko A.V., Gladilin G.P.
Organization: Saratov State Medical University
Summary:

The article presents the biographical data about Professor Vladimir Ivanovich Rubin, describing his academic contribution into the development of biochemistry and training of academic and pedagogical staff at the Saratov State Medical University.

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K. Rabov — a man of honor and devotion

Year: 2020, volume 16 Issue: №2 Pages: 530-533
Heading: the 75th Aniversary of the Victory in the Great Patriotic War Article type:
Authors: Norkin I.A., Ostrovsky V.V., Grishin S.E., Puchinyan D.M., Karyagina L.G., Ulyanov V.Yu.
Organization: Saratov State Medical University
Summary:

The article investigates the military and career details of biography of researcher of Saratov Research Institute of Traumatology, Orthopedics and Neurosurgery, V. K. Rabov. The analysis of V. K. Rabov's biography enables acknowledging the fact that heroic traits of his personality that were made evident during World War II manifested themselves with total devotion in everyday routine while providing medical care to patients.

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Reversibility of morphological changes in the spleen under the influence of intensive light deprivation

Year: 2020, volume 16 Issue: №2 Pages: 526-529
Heading: Рathophysiology Article type: Original article
Authors: Zlobina O.V., Ivanov A.N., Karetnikova A.Yu., Terekhina E.S., Shlyapnikov N.V., Trufanova Yu.Yu., Bugaeva I.O.
Organization: Saratov State Medical University
Summary:

The goal to assess the morphological and functional state of the spleen of white male rats under the influence of light desynchronosis and to analyze the degree of reversibility of these changes. Material and methods. The experiment was carried out in two stages on 60 white male rats, divided into five equal groups: control and four experimental. In the first series of the experiment, the first and second experimental groups were illuminated around the clock for 10 and 21 days. At the second stage, animals of the third and fourth groups were exposed to illumination around the clock for 10 and 21 days, and then kept in natural light for 21 days. The following morphological and morphometric parameters were evaluated: the area of the lymphoid follicle, T- and B-dependent zones of white pulp, the number of reproduction centers and immunoblasts in the T- and B-zones in 10 fields of view. Results. On the 10th day of the experiment, there was an increase in the area of the lymphoid follicle, T- and B-dependent zones, the number of immunoblasts when compared with the control. In animals of the third group, an increase in these indicators was observed. On the 21st day, a decrease in all measured values was noted. In animals of the fourth group, the indicators increased relative to the second experimental one and approached the control values. Conclusion. The detected morphological and functional changes in the spleen are associated with the negative effects of prolonged light deprivation on the organs of the immune system. However, indicators are subject to change.

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The role of histaminergic system in the effects of skin flap autotransplantation on microcirculation at absolute insulin deficiency

Year: 2020, volume 16 Issue: №2 Pages: 521-525
Heading: Рathophysiology Article type: Original article
Authors: Antipova O.N., Lagutina D.D., Stepanova T.V., Savkina A.A., Kuznetsova N.A., Andronova Т.А., Kiriyazi T.S, Ivanov A.N.
Organization: Saratov Medical University "Reaviz", Saratov State Medical University
Summary:

The objective of the article is to estimate the impact of the histaminergic system in the effects of skin flap autotrans-plantation (SFA) on microcirculation in white rats with alloxan insulin deficiency. Material and Methods: The studies were carried out in 60 white rats, divided into 3 groups: 20 control intact animals, 20 animals with alloxan diabetes — the comparison group, 20 animals with alloxan diabetes and SFA— the experimental group. The mechanisms of blood circulation modulation and perfusion of posterior paw dorsal skin, the concentration of histamine in the blood serum, and morphological changes in the SFAarea were evaluated. Results: The significant increase of skin perfusion on 43%, redistribution of microcirculation modulation active mechanisms and the increase in histamine serum concentration in 2,5 times underthe influence of SFA were observed in rats of the experimental group. Conclusion: The distant stimulating effect of SFA on microcirculation in conditions of absolute insulin deficiency is realized with increasing histamine serum concentration. Moreover, the stimulation of the blood flow regulation active mechanisms by increasing the histamine concentration is not equivalent — the effects on endothelium-dependent and neurogenic regulation mechanisms prevail, and the activation of histamine smooth muscle cell receptors is much less pronounced.

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Tendency in morbidity and primary disability among adult population of the Saratov region due to diseases of endocrine system, eating and metabolic disorders

Year: 2020, volume 16 Issue: №2 Pages: 511-514
Heading: public health Article type: Original article
Authors: Ponomarev A.D., Sazanova G.Yu.
Organization: Saratov State Medical University
Summary:

Objective: To analyze the tendency in morbidity and primary disability of adult population in the Saratov region due to endocrine system diseases, eating disorders and metabolic disorders. Material and Methods: Using analytical and statistical research methods, the official data on morbidity and disability levels of adult population in Saratov region for 2009-2018 was processed. Results: During the study period in the Saratov region there was an increase in primary and general endocrine system morbidity, eating disorders and metabolic disorders by 25.7 and 7.2%, a similar situation was recorded in the Russian Federation and Volga Federal District (by 41.8 and 25.7%); by 41.5 and 31.8%, respectively), the annual increase in the above class of diseases was 5±2.2%; the level of total endocrine system diseases, eating disorders and metabolic disorders among the adult population of the region is 14 and 20% higher than in the Volga Federal District and the Russian Federation, respectively. Conclusion: The data obtained during the study indicate a high level and steady growth of primary and general morbidity of endocrine system diseases, eating disorders and metabolic disorders in the Saratov region, which makes it urgent to conduct a study on the organization of medical care for patients with diseases of endocrine system.

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The deformation-strength properties of suture line of aponeurosis of anterior abdominal wall after laparotomy

Year: 2020, volume 16 Issue: №2 Pages: 506-510
Heading: Surgery Article type: Original article
Authors: Vertyankin S.V., Vanzha Ya.E., Mayorov R.V., Turlykova I.A., Golyadkina A.A., Polienko A.V., Inozemtsev E.S.
Organization: Saratov State Medical University, Saratov National Research University n.a. N. G. Chernyshevsky, Plekhanov Russian University of Economics
Summary:

Objective: development of a method for the prevention of postoperative ventral hernias based on an experimental assessment of the deformation-strength properties of aponeurosis in various types of median laparotomy. Material and Methods. 42 fascial-muscular-aponeurotic complexes of the anterior abdominal wall were evaluated. In accordance with a variant of the method for dissecting the aponeurosis and its suturing, the complexes are divided into two groups (21 samples each): group 1 —with a bypass of the umbilical ring on the left, group 2 — with the dissection of the umbilical ring. Results. Fascial aponeurotic complexes dissected and sutured through the umbilical ring, belonging to group 2, have higher mechanical characteristics. So, the average level of tensile stress (S), the average stress at maximum load (Load), Young's modulus (E), the average values of tensile strain, aponeurosis (D) and deformation at maximum load (Dmax) average level of maximum load (Smax) prevails in group 2 by 35.4; 39.8; 14.9; 34.6; 30.2 and 40.2%, respectively. Conclusion. The development, experimental application and evaluation of a new method for the prevention of postoperative ventral hernias after median laparotomy was performed based on the assessment of the deformation-strength properties of aponeurosis.

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Flexion-extension injuries of cervical spine: simulation capabilities and primary prevention of road traffic injuries (review)

Year: 2020, volume 16 Issue: №2 Pages: 500-505
Heading: Traumatology and Orthopedics Article type: Review
Authors: Ulyanov V.Yu., Salikhou Kh., Norkin I.A.
Organization: Saratov State Medical University
Summary:

The article reviews 37 Russian and foreign literature sources available at PubMed, E-library, Cyberleninka databases on flexion-extension injuries of the cervical spine, simulation capacities, and measures of traffic accident trauma primary prevention. The authors analyzed contemporary data on the mechanics of flexion-extension injuries of the cervical spine, described the capacities of simulation for this common trauma that brings significant medical and social consequences, and drew conclusions on the prospects of traffic injury primary prevention.

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Possibility of complex diagnostics of initial stages of osteoar-throsis

Year: 2020, volume 16 Issue: №2 Pages: 494-499
Heading: Traumatology and Orthopedics Article type: Original article
Authors: Romakina N.A., Gladkova Е.М., Titova Yu.I., Gladkova Yu.K.
Organization: Saratov State Medical University
Summary:

Objective: To evaluate capabilities of magnetic resonance imaging including T2 relaxometry in combination with laboratory studies of biological markers for diagnostics of hyaline cartilage pathology in the initial stages of knee joint osteoarthritis (OA). Material and Methods: 37 patients of both sexes aged 35-50 years suffering from intermittent pain and discomfort in their knee joints (the main group). The control group was made up of 20 persons of the same age without clinical manifestations of joint pathology. Instrumental research included radiography, ultrasonography, and magnetic resonance imaging of knee joints, including T2 relaxometry measurement. The cartilage oligomeric matrix protein (COMP) content and daily urinary losses of C-terminal telopeptides of collagen type II Urine CartiLaps (CTX II) were determined. Inflammatory activity was evaluated by serum interleukin-1 (3 (11-1(3) with multiplex analysis and C-reactive protein concentration. Results: The increased content of cartilage extracellular matrix biopolymers in the biological fluids (serum COMP, urine excretion Urine CartiLaps (CTX II)) and inflammatory activity was found in patients of the main group compared to those in patients of the control group. Correlation between the COMP concentration and T2 relaxometry digital data (in CU) was characterized as positive strong (R = 0.83), and between COMP and articular cartilage thickness (in mm) on ultrasound data as negative medium (R = -0.63). Interconnections of the same kind were found between the level of daily excretion CTX II and articular cartilage morphometry findings with ultrasound (R = -0.59). Conclusion: Structural changes in the extracellular matrix in early stages of OA can be objectified using T2 cartilage relaxometry and determining COMP as well as CTX II in biological media.

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Surgical management of thoracolumbar fracture-dislocation (clinical case)

Year: 2020, volume 16 Issue: №2 Pages: 488-494
Heading: Traumatology and Orthopedics Article type: Case report
Authors: Likhachev S.V., Zaretskov V.V., Ivanov D.V., Shulga A.E., Arsenievich V.B., Stepukhovich S.V., Mizyurov S.A.
Organization: Saratov National Research University n.a. N. G. Chernyshevsky, Saratov State Medical University
Summary:

The article presents a clinical case history of successful two-stage surgical reconstruction of a rare injury — a simple thoracolumbar fracture-dislocation (Type С AOSpine classification). The optimal arrangement of the stabilizing system at the stage of surgical intervention planning was designed using computer biomechanical simulation. The functional outcome was optimal ensuring complete reconstruction of the lost anatomy with no complication in post-operative period observed.

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