Saratov JOURNAL of Medical and Scientific Research

Dermatovenerology

Professor A.G. Ge —the founder of Kazan school of dermatologists and venereologists (to the 175th anniversary)

Summary:

The article is devoted to medical, scientific, pedagogical and public activities of A. G. Ge -professor of Imperial Kazan University, the prominent scientist dermatologist and venereologist of the end of the 19th and the beginning of the 20th centuries, the founder of the Department of Skin and Venereal Diseases and Kazan school of dermatologists and venereologists.

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Purpose and methods of teaching dermatovenereology to students of the medical university

Year: 2017, volume 13 Issue: №3 Pages: 686-688
Heading: Dermatovenerology Article type: Short message
Authors: Utz S.R., Slesarenko N.A., Eremina M.G., Eremin A.V., Utz I.A.
Organization: Saratov State Medical University
Summary:

 Higher education is based on the assimilation of theoretical knowledge acquired in the process of teaching, practical skills and the development of intellectual abilities leading to self-development and creative thinking. The ultimate goal of education is the education of the student's need for cognitive activity, the result of which will be competence in the profession, the ability to think in the terms of the dermatovenereology subject materials and the khowledge of it.

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R. Willan founder of the world scientific dermatology

Year: 2017, volume 13 Issue: №3 Pages: 681-685
Heading: Dermatovenerology Article type: Short message
Authors: Betechtin M.S., Zavyalov A.I.
Organization: Moscow State Medical Stomatological University n.a. A. I. Evdokimov, Saratov State Medical University
Summary:

 The article presents the biography of R. Willan ar|d his scientific and practical contribution to the development of European clinical medicine in the second half of the 18 century and in the establishment of world scientific dermatology.

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Photodynamic therapy of psoriasis

Year: 2017, volume 13 Issue: №3 Pages: 678-681
Heading: Dermatovenerology Article type: Review
Authors: Utz S.R., Dobdina A.Ju., Talnikova Е.Е., Utz I.A.
Organization: Saratov State Medical University
Summary:

The review presents literature data on the use of photodynamic therapy in the treatment of psoriasis. In addition, the article discloses aspects of the mechanism of action, indications and contraindications, as well as the development of possible side effects when using this phototherapeutic technique.

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2017_03-1_678-681.pdf392.64 KB

Assessment of the efficiency of cyclosporine use in psoriasis

Year: 2017, volume 13 Issue: №3 Pages: 673-678
Heading: Dermatovenerology Article type: Review
Authors: Kruglova L.S., Ponich E.S., Osina A.V., Gryazeva N.V.
Organization: Central State Medical Academy of the ADP of the Russian Federation
Summary:

The article presents a review of randomized studies involving patients with severe psoriasis, which showed that after 10-12 weeks of monotherapy with cyclosporine there was a decline of the Index of prevalence and severity of psoriasis (PASI). After achieving clinical remission must be decided on a gradual reduction of the dose of cyclosporine to the lowest effective dose, or the complete abolition of the medication. Simultaneous use of cyclosporine and UVB at the moment is not widely studied. Combined use of methotrexate and cyclosporine has been used successfully in the treatment of rheumatoid and psoriatic arthritis. The combined intake of cyclosporine and systemic biological agents should be used in exceptional cases of severe forms of psoriasis, not amenable to other treatments, and only for a limited period of time.

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2017_03-1_673-678.pdf306.37 KB

Vitiligo: modern methods of therapy

Year: 2017, volume 13 Issue: №3 Pages: 668-673
Heading: Dermatovenerology Article type: Review
Authors: Talnikova Е.Е., Svenskaya Yu.l., Dobdina A.Ju., Fatakhova Kh.V., Utz S.R.
Organization: Saratov State Medical University, Saratov state university
Summary:

This brief review focuses on the main issues of vitiligo treatment. The article provides insight into modern methods of dermatosis therapy discussing their potential, efficiency, safety, as well as represents a variety of standard treatment regimens.

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Analysis of the various schemes efficiency of methotrexate use in psoriasis treatment

Summary:

Currently, there has been a steady increase in the incidence of psoriasis, including severe forms. It is extremely important for psoriasis to administrate medicines in time. Methotrexate inhibits the increased proliferation of keratinocytes, inhibits the production of such inflammatory mediators as leukotrienes, TNF-a, collagenase, IL-1, IL-6, but at the same time it increases production of anti-inflammatory IL-10. Objective: to analyze the efficacy of methotrexate in various forms of psoriasis. Material and Methods. Under observation in the period from 2011 to 2016 were 516 patients, including those treated with methotrexate. Methotrexate was assigned according to the scheme: 1st injection 10mg/week, with no adverse effects 20-25 mg/week. All patients received folic acid at a dose of 20-40 mg/day for 5 days starting 3 days after the injection of methotrexate. Evaluation of efficiency was carried out using indices of dermatological status and quality of life. Results. Achievement of clinical remission was observed in 257 (49.7%) in patients; achieving a significant improvement was noted in 32 (6.2%) patients; achieving improvements in 126 (24.4%) patients; no effect 33 (6.4%) patients, and deterioration (further progression of skin lesions) were observed in 68 (13.2%) patients. Conclusion. Methotrexate has a high efficacy in such clinical forms of psoriasis as vulgar (64.9%), inverse (63.9%), exudative (44.7%), and pustular palmar-plantar psoriasis 12.9%.

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2017_03-1_662-668.pdf413.39 KB

Clinical polymorphism of lichen ruber planus

Year: 2017, volume 13 Issue: №3 Pages: 652-551
Heading: Dermatovenerology Article type: Review
Authors: Slesarenko N.A., Utz S.R., Bakulev A.L., Eremina М.G., Sherstneva V.N.
Organization: Saratov State Medical University
Summary:

The relevance of the topic is due to the high frequency of occurrence in the structure of dermatological diseases. The number of patients is steadily increasing, with children often becoming sick. The etiology of dermatosis is unknown. The review presents the data of domestic and foreign authors on the features of the clinical picture, variants of the flow of red flat lichen, depending on provoking factors.

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The role of dermatoscopy in diagnostics superficial disseminated actinic po-rokeratosis

Year: 2017, volume 13 Issue: №3 Pages: 648-651
Heading: Dermatovenerology Article type: Case report
Authors: Sherstobitova K.Y., Utz S.R., Shnaider D.A.
Organization: Saratov State Medical University
Summary:

We present a case of disseminated superficial actinic porokeratosis and describe general dermoscopic features.

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2017_03-1_648-651.pdf1.83 MB

A clinical case of Stevens-Johnson syndrome in a patient with pustular psoriasis

Year: 2017, volume 13 Issue: №3 Pages: 646-648
Heading: Dermatovenerology Article type: Original article
Authors: Utz S.R., Bakulev A.L., Morrison A.V., Igonina I.A., Ardalina O.O.
Organization: Saratov State Medical University
Summary:

Saratov Journal of Medical Scientific Research 2017; 13 (3): 646-648. The article presents a clinical case of Stevens — Johnson syndrome and generalized pustular patient with HIV-infection. The characteristic of anamnestic, clinical, laboratory data is present. The cause of acute allergic reactions and the formation of severe dermatosis in a patient with HIV-infection are considered.

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