Saratov JOURNAL of Medical and Scientific Research

Influence of optic disc size on the results of morphometric examinations at glaucoma

Year: 2020, volume 16 Issue: №1 Pages: 231-236
Heading: Ophtalmology Article type: Original article
Authors: Lvov V.A., Machekhin V.A., Fabrikantov O.L.
Organization: S. Fyodorov Eye Microsurgery Federal State Institution, Tambov State University n. a. G.R. Derzhavin

The purpose of the study is to analyze morphometric parameters of the optic disc, peripapillary retina and ganglion cells complex of the retinal macular area in eyes with different disc area. Material and Methods. 150 patients (294 eyes) aged 62.1 ±9.6 years old were examined (male — 69, female — 81). The eyes were divided into two groups according to the optic disc area (OD): eyes with average disc area (1.63-2.43 mm2) and eyes with small disc area (less than 1.63 mm2). Analysis of the morphometric structure of the OD, peripapillary retina and ganglion cells complex of macula was performed with Heidelberg laser retinal tomography HRT-3 and optical coherence tomography RTVue-100 (Optovue, USA). Computed perimetry of the central visual field was conducted using Carl Zeiss (USA) device with HFA30-2 software. Results. In the group of eyes with small discs according to HRT we revealed the significant difference in the OD parameters (cup area, rim area, cup/disc area) between normal eyes and eyes with preperimetric glaucoma, as well as in the group with average discs (p<0.001). We detected a significant difference of the peripapillary retina parameters (RNFL) between all stages of glaucoma, including normal limits, preperimetric and advanced stages of glaucoma in the group with small discs according to OCT. Conclusion. Both HRT and ОСТ have identical capability in early diagnosis of glaucoma, however, HRT evaluates the optic disc parameters better, while the ОСТ is preferable at peripapillar retina parameters evaluation. Preperimetric glaucoma, being the principal part of diagnosing glaucoma suspect, provides for accumulation of structural alterations of the optic disc and thus early detection of glaucoma.

1. Tatham A, Medeiros F, Zangwill L, Weinreb R. Strategies to improve early diagnosis in glaucoma. Progress in brain research 2015; 221: 103-33.
2. Erichev VP. Early glaucoma diagnosing: there are no any simple and reliable decisions. In: Glaucoma: problems and solutions: Collected papers. Moscow, 2004; p. 111-24.
3. Mardin CY, Horn FK, Jonas JB, et al. Preperimetric glaucoma diagnosis by confocal scanning laser tomography of the optic disc. Br J Ophthalmol 1999; 83: 299-304.
4. Hermann MM, Theofylaktopoulos I, Bangard N, et al. Optic nerve head morphometry in healthy adults using confocal laser scanning tomography. Br J Ophthalmol 2004; 88: 761-65.
5. Wang Y, Xu L, Zhang L, Yang H. Optic disc size in a population based study in northern China: The Beijing eye study. Br J Ophthalmol 2006; 90: 353-56.
6. Hoffmann EM, Bowd C, Medeiros FA, et al. Agreement among 3 optical methods for the assessment of optic disc topography. Ophthalmology 2005; 112: 49-56.
7. Nakamura H, Maeda T, Suzuki Y, Inoue Y Scanning laser tomography to evaluate optic discs of normal eyes. Jpn J Ophthalmol 1999; 43 (5): 410-4.
8. Seider Ml, Roland Y, Lee RY, et al. Disk Size Variability between African, Asian, Caucasian, Hispanic and Filipino Americans Using Heidelberg Retinal Tomography. J Glaucoma 2009; 18 (8): 595-600.
9. Jonas JB, Xu L, Zhang LY, et al. Optic disk size in chronic glaucoma: The Beijing eye study. Am J Ophthalmol 2006; 142: 168-70.
10. Hoesl LM, Mardin CY, Horn FK, et al. Influence of glaucomatous damage and optic disc size on glaucoma detection by scanning laser tomography. J Glaucoma 2009; 18 (5): 385-9.
11. Lvov VA, Machekhin VA, Fabrikantov OL. Comparative analysis of the morphometric parameters of the optic disc in glaucomatous eyes with average and large discs. Saratov Journal of Medical Scientific Research 2019; 15 (2): 510-4.

2020_01-2_231-236.pdf505.51 KB

No votes yet