Saratov JOURNAL of Medical and Scientific Research

Pseudomonas aeruginosa exotoxin A-induced hepatotoxicity in dynamics: an animal model in white mice

Year: 2015, volume 11 Issue: №4 Pages: 526-529
Heading: Physiology and Pathophysiology Article type: Original article
Authors: Morrison A.V., Popovich V.I., Morrison V.V.
Organization: Central Scientific Research Experimental Institute 33, Saratov State Medical University
Summary:

Purpose: to study biochemical indices of peripheral blood which show organs functional changes. Material and Methods. The experiments were carried out on white mice in dynamics development of pseudomonas aeruginosa caused by intraperitoneal injection of various dosage of exotoxin A. Results. The dosage-dependent disturbances in activity of transaminases, a-HBDH, in content of proteins, lipids and cholesterol were revealed. The received data have determined the hepatotoxic effect of pseudomonas aeruginosa exotoxin A on changes of biochemical blood markers of liver function. Conclusion. The expressed hepatotoxic effect of Pseudomonas aeruginosa exotoxin A has been determined during all the phases of experiment even at sublethal toxin dose.

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