№2, 2015, volume 11

Objective. The present study examines the value of intraoperative neurovisualization as an imaging tool for decision making in the management of traumatic nerve injuries. Materials and methods. 43 patients with traumatic nerve lesions were examined by electrodiagnostic study, ultrasonography and contrast neurography. Results. A complex intraoperative examination have been used to guide surgical decision making in patients with peripheral nerve injuries of limbs. Conclusion. The results of complex intraoperative examination became the basis of diagnosis and treatment algorithm for surgical treatment of peripheral nerves injuries.

Purpose: to establish the diagnostic value of the immune cells composition and cytokine activity of the cells in wound discharge from patients with acute odontogenic inflammatory diseases of maxillofacial region. Materials and methods. A total of 31 patients with acute odontogenic inflammatory diseases of maxillofacial region were examined. The number of immune cells and pro-inflammatory cytokines content (IL1(3, MCP1, IL6, IL8, TNFa) in the wound discharge were determined. Results. It has been established that depending on the severity of the inflammatory process in maxillofacial region the immune cells composition and levels of pro-inflammatory cytokines are changing. Conclusion. Determination of the immune cells composition and level of cytokines in the wound discharge can be used for estimation of the character and severity of acute odontogenic inflammatory processes in the maxillofacial region.

The aim: to prove the necessity of professional oral hygiene before the fixation of permanent orthodontic equipment in individuals with dental and facial anomalies based on the study of biomarkers of gingival fluid. Materials and Methods: Clinical, cytological examination and gingival fluid test on cytokine levels in 80 patients. Results: In patients with dentofacial anomalies observed decline in hygiene index, and increase the content of gingival fluid neutrophils and degenerative epithelial cells. It is accompanied by an increase in the concentration of the main group of pro-inflammatory and osteogenic cytokines, growth factors. Conclusion: Preliminary conducting professional oral hygiene to orthodontic treatment in patients with dentofacial anomalies leads to the conservation values of satisfactory hygienic indices of the mouth. In this case, the increase in the content of gingival fluid neutrophils and degenerative epithelial cells, with increased concentrations of the main group of pro-inflammatory and osteogenic cytokines has been defined insignificant.

Congenital malformation is one of the most common causes of infant mortality. The Russian Healthcare Ministry has approved a wide range of measures to decrease the number of babies born with malformations. Due to the measures taken, prenatal diagnostics of such malformations as cardiac malformation, nervous system malformation, various space occupying lesions has become more effective. However, there is a number of malformations hardly detected until the birth. This problem also concerns some abnormalities of the gastrointestinal tract. One of such malformations "silent" during prenatal diagnostics is, particularly, focal aplasia of the stomach muscular layer. This work deals with the case of such malformation observed in a newborn baby.

The aim is to study the characteristics of clinical and laboratory picture of neonatal diabetes mellitus in a premature baby; to analyze the course of the disease for 18 months, to determine the mechanisms of development of neonatal diabetes mellitus, to develop a differentiated approach in the treatment of neonatal diabetes mellitus.

The present article describes the case of prenatal diagnosis of placenta praevia vera by the ultrasound investigation in pregnant women with severe obstetric anamneses. The delivery was performed by cesarean section in a planned manner to conduct conserving surgery. The diagnosis of true placenta accreta was confirmed intraoperatively

The aim of the article is to analysis of the hemodynamic parameters of the uterus and cervix during the second and third trimesters of pregnancy. Material and methods. It was conducted dynamic ultrasound in 240 women with physiological course for singleton pregnancies in the period from 12 weeks of gestation until term labor. Results. For the second trimester of pregnancy redistribution of total uterine blood flow in the direction of increasing blood flow in more of the body than the cervix has been considered to be typical. From the third trimester of pregnancy until term labor a significant increase of blood supply to the cervix has been found; there has been a tendency to increase the capacity of the vascular channel and the reduction in peripheral resistance vessels of cervix. Conclusions. Early detection of disorders of uterine and cervical hemodynamics allows to predict the occurrence of various pathological conditions.

The Purpose: to determine the acute toxicity of new metal complexes of iron derived vinylimidazole and to reveal their antihypoxic activity in comparison with Acyzol and other known antihypoxic etomersol and hypoxen. Material and methods. Antihypoxic activity was studied in experiments on nonlinear white mice-males 4 models of acute hypoxia (hypobaric, hypoxia with hypercapnia, hemic, histotoxic). Rates of acute toxicity (LD16, LD LD ) were calculated graphically by the method of Miller and Tainter. Changes in oxidative metabolism in mice under the influence of the most active compounds were assessed by the values of oxygen consumption and rectal temperature. Results. The studied metal complexes of iron are small and moderately toxic. The connection under the code of Tetravim on the severity of antihypoxic effect (the increase in life expectancy male mice compared to control groups on 20-127%) in the range of doses studied (5-250 mg/kg, i/p) is superior to other derivatives of vinylimidazole known and antihypoxic: etomersol (25-100mg/kg, i/p) and hypoxen (50-150 mg/kg, i/p). Conclusion. The obtained data on the pharmacological activity of Tetravim require further clarification of the mechanism of antihypoxic effect and clinical trials with the aim of putting it on the drugs market as a promising antihypoxic agent.

Tftea/mofthis workisto study the left ventricular myocardial hypertrophy. Materials and methods: In the study that was held in period from 2008 to 2013 years and covers group of 7959 workers of locomotive brigades of Transbaika-lian railway. In stated period each individual was additionally searched for the risk factors and lesions in target-organs in time of medical examinations undergoing. Results: During the study in group (7959 observations with the terminal outcomes) 597 cases of the left ventricular myocardial hypertrophy were found and statistically analyzed. It has been found that arterial hypertension, age, retinopathy, diabetes mellitus, thickening of the intima — media complex of more than 0.9 mm/atherosclerotic plaques of the carotid arteries, body mass index >25.0, and atherosclerosis of the aorta, hyperglycemia and stress led to the development of the left ventricular myocardial hypertrophy. Conclusions: This causative and effect conditionality should be considered in the prevention and treatment of the left ventricular myocardial hypertrophy.

Objective: to study the influence of CCPA and RF on 5-year outcomes in patients with early rheumatoid arthritis (RA). Subjects and methods. 204 patients with early RA (<2 years) according to American College of Rheumatology criteria included in the study from 2003 to 2007 (67,5% RF (+); 57% ACCP (+), 86,5% women aged 49 [40-58]). They were treated by DMARDs including the biologic therapy (24%) according the «tight-control» principle. Results. During the first four years the CCPA (+) (n=117) reliably had the higher level of the disease activity. While in the CCPA (-) group (n=87) mainly recorded the low activity and the remission. Baseline DAS28 (M±a) was 5,30±1,09 (compared 4,92±1,18), p<0,05. Froml to 5 years — 3,65±1,65 (3,18±1,24), 3,35±1,13 (2,99±1,11), 3,15±1,49 (2,65±1,11), 3,04±1,32 (2,58±1,09), p<0,05; 3,57±1,56 (3,32±2,41), p>0,05. Between RF (+) (n=138) and RF (-) (n=66) groups we did not find differences (p>0,05). Radiological damage in the CCPA(+) patients was more pronounced from the second year of the observation. Baseline, after 1 year SHS (M±o) was 19,7±10,5 (compared 15,1±8,9), 25,4±16,8 (20,3±12,2), p>0,05. From 2 to 5 years — 33,5±20,8 (25,3±14,2), 40,8±26,8 (31,9±20,2), 48,0±28,8 (37,2±22,6), 55,6±30,5 (44,0±24,5), respectively, p<0,05. This trend was determined in RF-positive patients. Conclusion. The CCPA- and RF-positive patients have the worst of 5-year radiological outcomes. CCPA-positive patients also have the worst clinical course during the first 4 years.