The value of composition and cytokine activity of wound discharge cells in patients with acute odontogenic inflammatory diseases of the maxillofacial region
Heading: Stomatology Article type: Original article
Authors: Lepilin A.V., Zakharova N.B., Fedotenkova D.A., Tereshkina N.E.
Organization: Saratov State Medical University
Purpose: to establish the diagnostic value of the immune cells composition and cytokine activity of the cells in wound discharge from patients with acute odontogenic inflammatory diseases of maxillofacial region. Materials and methods. A total of 31 patients with acute odontogenic inflammatory diseases of maxillofacial region were examined. The number of immune cells and pro-inflammatory cytokines content (IL1(3, MCP1, IL6, IL8, TNFa) in the wound discharge were determined. Results. It has been established that depending on the severity of the inflammatory process in maxillofacial region the immune cells composition and levels of pro-inflammatory cytokines are changing. Conclusion. Determination of the immune cells composition and level of cytokines in the wound discharge can be used for estimation of the character and severity of acute odontogenic inflammatory processes in the maxillofacial region.
Bibliography:
1. Tsepov AM, Orekhova LYu, Nikolayev Al, et al. Some aspects of etiology and pathogenesis of chronic inflammatory generalized periodontal diseases (literature review): Part 1. Parodon-tologiya 2005; 2 (35): 3-6
2. Korotkikh NG, Toboyev GV. Abscesses and phlegmon face: diagnosis, treatment, prognosis. Voronezh: IPOSOIGSI, 2010; 90 p.
4. Solov'yov MM, Bol'shakov OP Abscesses and phlegmon of head and neck. M.: Medpress-inform, 2003; 230 p.
5. Shmagel KV, Bel'ayeva OV, Chereshn'ov VA. Modern views on periodontal disease immunology. Stomatology 2003; 1: 61-64
6. Ostanin АА, Leplina OYu, Tikhonova MA, et al. Cyto-kine-mediated mechanisms of systemic immunosuppression in patients with purulent surgical pathology. Cytokines and Inflammation 2002; 1 (1): 38-45
7. Avdeyeva MG, Shubich MG. Pathogenetic mechanisms of initiation of systemic inflammatory response syndrome (review). Clin Lab Diagnostics 2003; 6: 3-9
8. Abakumov MM, Bulava GV, Borovkova NV, et al. Clinical evaluation of immune parameters in surgical patients with systemic inflammatory response syndrome. Surgery 2007; 8: 24-28
9. Simbirtsev AC. Cytokines: classification and biological functions. Cytokines and Inflammation 2004; 3 (2): 16-22
10. Yerokina NL, Lepilin AV, Zakharova NB. Profile of cytokines in contents of periodontal pockets in patients with fractures of the bottom jaw and periodontitis. Clin Lab Diagnostics 2011; 9: 6-7
11. Konenkov VI, Rakova IG, Avdoshina VV, Gelfgat EL. Estimation of spontaneous cytokine production in culture peripheral blood mononuclear cells of a healthy person. Cytokines and Inflammation 2005; 4 (2): 33-37.
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