Saratov JOURNAL of Medical and Scientific Research

Mathematical modeling of structural indices of thyroid gland in thyroid pathology

Year: 2014, volume 10 Issue: №1 Pages: 38-44
Heading: Macro- and Micromorphology Article type: Original article
Authors: Kalmin O.V., Kalmin О.О..
Organization: Penza State University

Purpose: the complete analysis of the morphological parameters of the thyroid gland in various forms of thyroid pathology by methods of mathematical modeling. Material and Methods. Histologically examined samples of operating thyroid glands of 199 patients of both sexes aged 21 to 74 years, were treated surgically. Experimental data were studied by factorial and discriminant analysis. Results. When the factor analysis of 60 experimental parameters were identified 14 major factors that indicate 14 main trends in the dynamics of the structure of the thyroid gland due to an increase in severity of pathological processes. Discriminant analysis showed that the study of quantitative structure of the thyroid gland there may be cases of erroneous inclusion in the theoretical option groups, however, the study of the entire set of indicators observed a 100% correct distribution of cases by groups of pathology. Conclusion. As a result, the factor of the original system of 60 morphological parameters of thyroid pathology in various forms has been minimized to 14 new uncorrelated parameters (main factors), reflecting changes in the morphology of the basic laws of the pathology of the gland. As a result of the discriminant analysis of morphological parameters of the thyroid gland in different types of its pathology the importance of semi-quantitative parameters of thyroid structure has been revealed.

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