2013, volume 9

On the basis of literary data the role of matrix metalloproteinases in many pathogenetic processes was showed. It was estimated the importance of the different types and subtypes of matrixes in the pathogenesis of psoriasis. Analysis of comorbidity was given. The status of the interstitial metabolism in patients with psoriasis with cardiovascular complications metabolic syndrome cancer, the impact of MMP on angiogenesis in psoriasis.

The review presents the results of the research of acne phototherapy. The foundational photobiological principles of acne therapy are considered, biomedical and therapeutic values of different wave lengths are discussed, a clinical case of laser technologies use is presented.

This article represents a survey-analytical study of interrelationship of psoriasis and metabolic syndrome of children. The research and analysis was carried out from publications in the markers of metabolic syndrome had been explored. Much attention had been focused on population, clinical, age group and gender peculiarities of these conditions in different countries.

There had been organized the analysis of the current ideas on the etiology, pathogenesis, therapeutic methods of acne treatment. The use of infrared radiation (Photo Dyn750) is a promising technique in the treatment of acne.

In this review, the synthesis of the achievements in the field of fluorescence of the skin exposed to ultraviolet radiation.

The article presents possible molecular mechanisms for rosacea pathogenesis from current domestic and foreign clinical observations and laboratory research: regulation and expression defects of antimicrobial peptides, vascular endothelial growth factor, the effect of serine proteases, oxidative stress, reactive oxygen species and ferritin on the occurrence and course of rosacea. New developments in molecular biology and genetics are advanced for researching the interaction of multiple factors involved in rosacea pathogenesis, as well as providing the bases for potentially new therapies.

The article presents an overview of the domestic medical literature, reflecting the incidence of syphilis in the Russian army and the Russian military civilians in times of conflict in the XVII — beginning of XX century. The methods of struggle with sexually transmitted diseases and their prevention in the military in wartime and peacetime are present.

The goal: to give a characteristic of the personality profile, a comparative evaluation of psychosomatic changes in patients with psoriasis and HIV-associated psoriasis. Materials and methods. The study involved 27 patients aged
18-65 years with psoriasis and HIV-associated psoriasis, and isolated comorbid mental disorders and patients without skin disease, formed the control group. The survey in all patients was conducted with clinical-dermatological method, supplemented by psychometric methods (Hospital Anxiety and Depression Scale (HADS), the Hamilton Scale for Depression (HDRS)). Results. Analysis of the psychological status of patients with psoriasis demonstrated a high frequency of mental disorders in these patients.

The aim: To determine the nature and frequency of side effects observed on acitretin therapy of patients with severe forms of psoriasis. Materials and methods. The study included 20 patients with generalized pustular psoriasis. Due to the inefficiency of the ongoing standard therapy, in addition to the plan of treatment, all patients were included systemic retinoid — acitretin (neotigazon) at a dose of 0,3-0,5 mg/kg per day. I control group consisted of patients with psoriasis receiving standard therapy without the use of systemic retinoids. II control group consisted of patients taking acitretin about keratosis. Results. In 18 patients of the main group noted the development of side effects, such as xerosis and nail fragility. In 14 patients of the main group and 3 patients of the II control group the results of urinalysis tests and Nechiporenko sample were detected by elevated levels of red blood cells and the development of hematuria. Conclusion. The study found that 17 patients had development of hematuria, which can be considered regarded as a side effect of acitretin therapy.

The study presents the results of the psychosocial influence of atopic dermatitis as an essential component of the global burden disease. With the help of the disease-specific questionnaire «Dermatology specific quality of life» (DSQL) there had been found out that atopic dermatitis had a strong negative effect on the physical status, social functioning and mental well-being of the patient»s daily activity, self-perception, causing maladjustment of the respondents, especially in a period of acute symptoms. In addition to addressing the medical aspects of blood pressure an important role in reducing the burden of disease play an individual educational programs and psychological support for patients while creating partnerships «doctor-patient» relationship.