Saratov JOURNAL of Medical and Scientific Research

2011, volume 7

Assessment of alveolar-capillary disturbances in development of severe hemodynamic pulmonary edema in rats and their correction with SHF radiation

Year: 2011, volume 7 Issue: №2 Pages: 389-392
Heading: Physiology and Pathophysiology Article type: Original article
Authors: Terekhov I.V., Dzyuba M.A., Bonder S.S., Nadzharian L.G.
Organization: Saratov Military Medical Institute

The article presents the study on the effect of SHF radiation of 0.01-0.2-mcW/cml intensity on alveolar-capillary permeability state and rat survival with hemodynamic adrenaline pulmonary edema in vitro. Animals of different sex showed dissimilar sensitivity to edema adrenaline action and to super high frequency of SHF radiation. SHF radiation of 0,05 MW/cml is optimal from the viewpoint of its effect for the period of survival of both male and female rats, accompanied by prolongation of their life span to 59.2% and 95.5% respectively. The hypothesis of modulating action of low intensity SHF radiation on endothelial functional state has been considered. It results in rehabilitation of cardiovascular system reactivity and significant prolongation of life span.

Keywords: survival, SHF radiation of nonthermal intensity, rats, endothelial function, adrenaline pulmonary edema

Topicality of ischemic heart disease prophylaxis in specialists of medical-social expertise

Year: 2011, volume 7 Issue: №2 Pages: 387-389
Heading: Physiology and Pathophysiology Article type: Author's opinion
Authors: Krovyakova Е.А., Kirichuk V.F., Kodochigova A.I.
Organization: Saratov State Medical University

Realization of professional duties for specialist of medical-social expertise is accompanied with high intellectual and emotional obligations. Daily extreme and psychogenic situations lead to psychological and occupational maladjustment of physicians, development of anxiety and depression among them, which can be exacerbated by the presence of alexithymia. Negative psycho-emotional factors increase the risk of coronary heart disease. In order to prevent this pathology development in specialists of medical-social expertise, identification of changes in their psycho-emotional sphere and personified correction of revealed disorders are necessary

Keywords: stress, medico-social factors of activity, depression, anxiety level, alexithymia

Comparative analysis of psychophysiological characteristics of clinically healthy persons with an average teeth resistance to caries harmonious and anxious personality types

Year: 2011, volume 7 Issue: №2 Pages: 385-387
Heading: Physiology and Pathophysiology Article type: Short message
Authors: Khalturina V.G., Kirichuck V.F., Kodochigova A.I., El-bubu М.М. M. A., Kucherov M.G.
Organization: Saratov State Medical University, Penza Regional Children's Clinical Hospital n.a. N.F.Filatov

When analyzing the results of psychophysiological study of healthy individuals aged 18 to 30 years with an average teeth resistance to caries of harmonious and anxious personality types, it was revealed that the number of representatives of anxious type were more than of harmonic type; and high neuroticism, anxiety and conflicting intrapersonal tendencies which are the risk factors for dental caries origin and progression, were observed in their personal radical. In this regard, the plan of preventive arrangements for carious process progression in clinically healthy persons of anxious psycho-type seems to be the rational measure

Keywords: psychophysiological type of individual, caries resistance, caries, anxiety level

Chronic lymphocytic leukaemia: contemporary conceptions of etiology, pathogenesis and peculiarities of clinical manifestations (review)

Year: 2011, volume 7 Issue: №2 Pages: 376-385
Heading: Physiology and Pathophysiology Article type: Review
Authors: Zhevak T.N., Chesnokova N.P., Shelekhova T.V.
Organization: Saratov State Medical University

The research work presents an analysis of literature review and results of investigations on the problems of etiology, pathogenesis, classification and peculiarities of clinical manifestations of chronic lymphocytic leukaemia. Special attention is paid to both contemporary conceptions of carcinogenesis, reflecting the role of proto-oncogenes activation, an-tioncogenes and apoptosis genes suppression in mechanisms of neoplasia development and «specific mechanisms» of oncogenic transformation induction of B-lymphocytes and the subsequent development of the stages of promotion, progression and marked clinical manifestations of formation. Possibility of further improvement of use of immune phe-notype character and oncomarkers in diagnostics of chronic lymphocytic leukaemia clinical variants and in evaluation of effectiveness of its therapy has been indicated in the article

Keywords: proto-oncogenes, marker molecules, cytokines, chronic lymphocytic leukaemia, C-reactive protein, apoptosis

Prehospital medical emergency aid given to persons aged 15-24

Year: 2011, volume 7 Issue: №2 Pages: 372-376
Heading: Health Service Organization Article type: Original article
Authors: Bolotnikova N.I.
Organization: Astrakhan State Medical University

The research goal is a quantitative and a qualitative analysis of emergency calls in Astrakhan during 2008. The method of complete observation was used in the research work. Data from the call charts of Emergency Service were thoroughly analyzed. Cases of emergency aid to the young working population ages 15-24 were under the study. 55,5% of cases were patients with acute diseases and 46,5% of emergency cases were as a result of accidents. The correlation between the number and character of nosology, and the age and sex of patients were determined. It was proved that the results of the given research would significantly improve the Emergency Service organization

Keywords: young working population, nosology, emergency aid

Problems and solutions on issues of medical care quality in community-acquired pneumonia in hospitals of Saratov region

Year: 2011, volume 7 Issue: №2 Pages: 368-372
Heading: Health Service Organization Article type: Original article
Authors: Erugina M.V., Grozdova T.Yu., Savinov V.A. Sazanova G.Yu.,Dolgova E.M., Lotsmanov Yu.F., Ushakov Yu.V.
Organization: Saratov State Medical University

Qualitative assessment of diagnostics and treatment of patients with community-acquired pneumonia (CAP) was carried out in ten therapeutic departments of urban and district hospitals of Saratov region, using quality indicators (Qls). Each case of CAP was assessed in expert health care quality (HCQ) card according to the diagnostic and treatment quality federal standards and the basic Ql. The application of Ql in CAP patients allowed revealing the following: low CAP agent isolation rate; late hospitalization of CAP patients; low frequency of sputum bacteriological and bacterioscopic investigations prior to antibiotic therapy; insufficient frequency of step-by-step introduction of antibiotics. Recommendations on CAP patients dispenserization were not properly prescribed; recommendations on vaccination were absent. The basic measures of HCQ improvement are as follows: organizing for each CAP patient therapeutic and diagnostic quality control according to Ql; quick administrative decisions; using of HCQ expertise during the first 2-3 days of treatment to correct diagnosis and treatment; optimizing hospital diagnostic resources (laboratory and instrumental) and rational pharmacotherapy

Keywords: quality indicators, health care, community acquired pneumonia

Criteria of medical care evaluation in daily in-patient department in pediatrics

Year: 2011, volume 7 Issue: №2 Pages: 361-368
Heading: Health Service Organization Article type: Original article
Authors: Shigaev N.N., Grozdova T.U.
Organization: Saratov Socio-Economic Institute of Plekhanov Russian University of Economics

The research goal is to work out criteria for the evaluation of medical care quality. Materials included 386 medical cards of daily in-patients, 216 medical cards of in-patients; 602 cards of analysis of case histories; 4 computer data bases. Methods of mathematical statistics were successfully used in the study. The comparative method of data analysis was applied to the research work. Intensity of medical care in values from 0,1 to 0,5 conditional units corresponded to requirements of criterion of estimation of medical care quality. Parameters of medicinal treatment were close to the standards of treatment in interval from 44,4 to 100%, as criterion of quality of medical care. Specific weight of apparatus and instrumental researches constituted an interval from 7, 4% to 22, 6%, forming corresponding criterion. Interval of effectiveness according to standards of consultations is from 0, 26 to 1, 04 conditional units. In conclusion the article stated that the characteristics for criteria to evaluate medical care in daily in-patient departments were worked out on the basis of indices obtained during the research work

Keywords: quality evaluation, medical care, daily in-patient treatment

Morphological characteristics of sphincter zone glands of urinary bladder in different stages of postnatal ontogenesis

Year: 2011, volume 7 Issue: №2 Pages: 357-361
Heading: Macro- and Micromorphology Article type: Original article
Authors: Shadlinskiy V.B., Guseynova G.A., Mamedov N.M.
Organization: Azerbaijan Medical University

Methods of macromicroscopy and morphometry have been used to study sphincter zone glands by 54 total preparations of a urinary bladder received from corpses of people of different ages without any pathology of organs of urine-genital apparatus. The glands were painted by 0, 05% methylene blue solution and were investigated with the application of stereomicroscopic-binocular microscope MBS-9. Microscopic sections of sphincter zone glands in the thickness 5-7 microns were stained with hematoxylin-eosin, azure-2-eosin and with hematoxylin-picrofucsin by Van-Gizon technique. Sphincter zone glands are arranged firmly without dependence on age, length and width of initial department of glands of these zones. In postnatal ontogenesis size indices of sphincter zone glands have been essentially changed. These indices are equal for left and right ureter sphincter zone glands

Keywords: urinary bladder, sphincters, postnatal ontogenesis, glands

Morphokinetics of mesenterial lymphatic node cell populations in exposure of gold nanoparticles within experimental work

Year: 2011, volume 7 Issue: №2 Pages: 353-357
Heading: Macro- and Micromorphology Article type: Original article
Authors: Zlobina O.V., Bugaeva I. О., Maslyakova G.N., Firsova S.S., Bucharskaya А.В., Khlebtsov N.G., Khlebtsov B.N., Dykman L.A.
Organization: Saratov National Research University n.a. N. G. Chernyshevsky, Saratov State Medical University

The research goal is to investigate the influence of gold nanoparticles with different size (1-3 nm, 15 nm and 50 nm) on the morphokinetics of mesenterial lymphatic node cell populations of healthy laboratory animals. Experiment included 24 white rats. The investigation was conducted in 4 groups of animals. The animals were administered the gold nanoparticles orally for 15 days. It was established that the oral administration of gold nanoparticles caused the changes of morphokinetics of mesenterial lymphatic node cell populations. The morphological alterations in the mesenterial lymphatic nodes assisted in activation of migration processes, the proliferation and differentiation. The immu-nomodulatory action of gold nanoparticles was proved

Keywords: mesenterial lymphatic nodes, gold nanoparticles, cellular populations

Hygienic evaluation of effectiveness of drinking water purification facilities in Saratov institutions of social significance

Year: 2011, volume 7 Issue: №2 Pages: 350-353
Heading: Hygiene Article type: Original article
Authors: Lavrentiev M. V.
Organization: Saratov State Medical University

The purpose of the given work was studying of overall performance of the local equipments on water treating, both on superficial, and on underground sources of water supply. Material and metods. In research 60 assays of water from various superficial, underground reservoirs and planting system of water supply of the Saratov region have been selected and 900 definitions of the maintenance of chemical substances are spent. Results. Priority pollutants of underground waters in the Saratov and Fedorovsky districts of the Saratov region, it are established: rigidity salts, iron. For superficial sources of the same districts of area it: iron, manganese, Phenolum, Natrii phosphases. Water of open reservoirs also didn»t satisfy on organoleptic indicators and indicators of processes of self-cleaning. Efficiency of water-purifying constructions of Fedorovsky district, has appeared low. Water from underground sources got to the consumer without passage through water-purifying constructions. The conclusion: 1) water of underground and superficial reservoirs of rural settlements of the Saratov region has adverse organoleptic indicators and contains chemical pollution in the concentration exceeding maximum permissible; 2) efficiency of rural water-purifying constructions doesn»t allow to spend water treating according to SanPiN; 3) application of the local equipments on potable water clearing has allowed to achieve reception on an exit from them the quality corresponding to demands SanPiN

Keywords: the local equipments, potable water, clearing