Saratov JOURNAL of Medical and Scientific Research

Morphokinetics of mesenterial lymphatic node cell populations in exposure of gold nanoparticles within experimental work

Year: 2011, volume 7 Issue: №2 Pages: 353-357
Heading: Macro- and Micromorphology Article type: Original article
Authors: Zlobina O.V., Bugaeva I. О., Maslyakova G.N., Firsova S.S., Bucharskaya А.В., Khlebtsov N.G., Khlebtsov B.N., Dykman L.A.
Organization: Saratov National Research University n.a. N. G. Chernyshevsky, Saratov State Medical University

The research goal is to investigate the influence of gold nanoparticles with different size (1-3 nm, 15 nm and 50 nm) on the morphokinetics of mesenterial lymphatic node cell populations of healthy laboratory animals. Experiment included 24 white rats. The investigation was conducted in 4 groups of animals. The animals were administered the gold nanoparticles orally for 15 days. It was established that the oral administration of gold nanoparticles caused the changes of morphokinetics of mesenterial lymphatic node cell populations. The morphological alterations in the mesenterial lymphatic nodes assisted in activation of migration processes, the proliferation and differentiation. The immu-nomodulatory action of gold nanoparticles was proved

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