2010, volume 6

The article deals with the problem of modern medical care for the working population. It presents the data concern¬ing organization of medical care for workers of oil producing and oil-refining industry, and tendencies of development of medical organizations various in property forms in the system of rendering medical aid for the employees. It has been determined that the processes of medical care for the industrial workers need to be optimized, and it is possible in the united economic-organizing system that allows to provide succession and complete correspondence to medical and social needs of the working population

In the article the correspondence between the structure of clinical and pathologic diagnoses was analyzed. Adequacy of underlying disease and adequacy of complication in clinical and pathologic diagnoses was also analyzed. While performing analyses, specific characters of making diagnoses in therapeutic, surgical departments and reception rooms were studied. Summing the received data, special attention was paid to cardiological diseases as nosologies which take the leading place in mortality rate

The purpose of the research is to perform qualitative and quantitative analysis of emergency calls for children and teenager with intoxications in Astrakhan in 2005. Continuously observing cases of death from intoxication in children and teenagers aged 0-19 years in Astrakhan from 2003 till 2005 years have been examined according to the statistics of Astrakhan department (reg. form 5). Premedical aid given to children and teenagers has been thoroughly analyzed by means of data from the medical cards of ambulance calls filled in by emergency doctors (reg. form 110/u). In 2005 the total amount of emergency calls in case of intoxication counted 5,5% of 17,5% of accident calls. Statistics based on age groups of patients presented as follows: children ages 0 to 11 months 29 days - 4,9%, сchildren ages 1 to 4 years - 31,9%, сchildren ages 5 to 9 years - 4,5 %, teenagers ages 10 to 14 years - 17,1%, 15 to 19 years - 41,1%

The goals and objectives of bioinformatic science are presented in the article. The main methods and approaches used in computer biology are highlighted. Areas in which bioinformatic science can greatly facilitate and speed up the work of practical biologist and pharmacologist are revealed. The features of both the basic packages and software devices for complete, thorough analysis of macromolecules and for development and modeling of ligands and binding centers are described

The work is a result of the psychophysiological tests with the help of cutting examination and psychogeometrical tests for 76 healthy individuals ages 20,18±1,25 years, having different caries resistance. It is known that group of people with poor caries resistance has a conflict type of personality. There is a positive tendency to growth of anxiety level and reducing caries resistance. The article concludes that the prophylaxis of caries and its complications must contain methods of psychophysiological correction

The research was aimed to generalize the results of own investigations pertaining to activation of lipid peroxidation in pathogenesis of rectal cancer, endometrial cancer, thyroid cancer and breast cancer. the research shows that extreme intensification of lipoperoxidation processes being a regular manifestation of paraneoplastic disorder and correlating to the degree of spread of neoplasias with different localization needs appropriate medical treatment

The article highlights and generalizes data presented in native and foreign scientific literature. It is devoted to the structure, synthesis and procalcitonin secretion by different cells. The main objective of the work is the significance of procalcitonin determination in septic state diagnostics

The results of study of body functional status of members of Navy ship crews during sea campaigns and in the process of military professional adaptation have been analyzed. Psycho-physiological specificity of professional activity and regularity in changes of psycho-physiological parameters of military seamen have been estimated. Organization-staff and assessment-corrective measures of effectiveness improvement of psycho-physiological support of Navy ship crews' professional activity have been worked out

The aim of the research is to study pharmacological properties and to determine safety effect diapason, toxico-logical properties of new adenine substances 9-[2-(4-isopropylphenopxy) aethyl] adenine under laboratory code VMA-99-82 which obtains antiviral activity in vitro. the results of the research of neurotoxicologic profile of combination of VMA-99-82 are presented in the work using technique of multistage testing according to «S.lrvin». while performing the research it has been established that safety level of substance VMA-99-82 refers to the class of low toxic combination. the diapason of doses (from 18,7 to 300 mg/kg) of substance evident therapeutic effect has been determined. Side-effects are not expressed significantly. therapeutic effect of the combination VMA-99-82 has behavioral reactions. thus the given substance must be further studied for psychotropic effect and its mechanism action

The purpose of the research is to evaluate the clinical effectiveness of cyclosporine and other antihistamines in patients with chronic forms of urticaria resistant to basic first-line therapy. Open randomized controlled study has been performed in parallel groups. 53 patients with chronic idiopathic urticaria ages 18-50 years have been examined. In case of ineffectiveness of previous therapy, patients have been randomized into 2 groups: group I receiving cyclosporine (Sandimmune Neoral ®) 2,5 mg/kg/day, group II receiving cetirizine (Zyrtec ®) 10 mg/day and ranitidine (Zantac ®) 300 mg/day orally. It has been found that the administration of cyclosporine in patients with severe chronic idiopathic urticaria provides a more rapid achievement of clinical effect than the therapy with H1/H2 histamine antagonists. It is confirmed by a significant decrease of total index of severity of illness and major symptoms of skin lesions. This tendency towards normalization of quality of life of patients taking cyclosporine remains during 8 weeks after the medication. Thus administration of cyclosporine can be considered as therapy of choice in patients with chronic idio-pathic urticaria with a severe course and ineffective long-term therapy with antihistamines / systemic corticosteroids