Острый коронарный синдром и анемия: особенности выбора оптимальной врачебной тактики (обзор)
Рубрика: Тематическое приложение Тип статьи: Обзор
Авторы: Пучиньян Н.Ф., Фурман Н.В., Малинова Л.И., Довгалевский Я.П.
Организация: ФГБОУ ВО Саратовский ГМУ им. В.И. Разумовского Минздрава России, ГУЗ «Областной клинический кардиологический диспансер»
В обзоре оценивается по данным литературы клинико-патогенетическая значимость анемии у пациентов с острым коронарным синдромом (ОКС). В указанной клинической ситуации выделяются проблемы выбора оптимальной терапии, связанные с наименьшей доказательной базой. Для этого проанализированы результаты клинических исследований, опубликованных в библиографических базах: PubMed, Publons и eLibrary (в обзор вошло 40 публикаций за 1989-2020 гг.). Наиболее хорошо изученными являются эпидемиологические особенности анемического синдрома у больных с ОКС (максимальное количество исследований). Анемия широко распространена при ОКС и ассоциирована с неблагоприятным прогнозом. Остается нерешенным вопрос, играет ли анемия прямую причинно-следственную роль в ухудшении краткосрочной и долгосрочной заболеваемости и смертности, или это скорее показатель плохого клинического состояния. Отдельного изучения, вследствие минимальной доказательной базы, требует выбор оптимальной антитромботической терапии при ОКС у больных с анемией: как конкретных препаратов, так и длительности их приема.
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