Saratov JOURNAL of Medical and Scientific Research
Home

Levels of systemic inflammatory biomarkers in patients with atrial fibrillation: Analysis based on a comparison of propensity scores

Year: 2025, volume 21 Issue: №1 Pages: 37-43
Heading: Cardiology Article type: Original article
Authors: Basieva M.A., Talibova S.M., Kazanova P.V., Avanesyan G.A., Ispiryan A.Y., Filatov A.G., Donakanyan S.A., Shvartz V.A.
Organization: Bakoulev National Medical Research Center for Cardiovascular Surgery
Summary:

Objective: to compare the levels of biomarkers of systemic inflammation between groups of patients with paroxysmal and persistent forms of atrial fibrillation (AF). Material and methods. The study included 232 patients diagnosed with AF who underwent the primary procedure of pulmonary vein ablation. The average age was 62 (54;67) years. Patients were divided into two groups: with paroxysmal and persistent forms of AF. Results. As a result of the analysis of the levels of inflammatory markers, no statistically significant differences were found between the groups. For systemic inflammatory response index, 0.8 (0.6; 1.1) vs 0.9 (0.7; 1.1); p=0.077; for systemic inflammation index 361 (276; 509) vs 373 (294; 551); p=0.505; for aggregate inflammation systemic index 170 (122; 255) vs 197 (139; 259); p=0.150; for neutrophils lymphocytes ratio 1.6 (1.3; 2.2) vs 1.8(1.3; 2.3); p=0.428; for platelets lymphocytes ratio 122 (86; 132) vs 107 (91; 130); p= 0.576; for monocytes lymphocytes ratio 0.228 (0.177; 0.291) vs 0.241 (0.2200; 0.301); p=0.262. After statistical correction for the initial clinical characteristics, no differences were also obtained. According to the ROC analysis, no statistically significant threshold values of the levels of the studied markers were found for each form of AF. Conclusion. In this study, there was no difference in the level of "new" biomarkers of systemic inflammation between patients with paroxysmal and persistent forms of AF. Currently, data on the existence of an association between the levels of biomarkers of systemic inflammation and various forms of AF are contradictory, further research in this direction is required.

Keywords: systemic inflammatory response index, systemic inflammation index, inflammation, biomarkers of inflammation, aggregate inflammation systemic index

Bibliography:
1. Ни Z, Ding L, Yao Y. Atrial fibrillation: Mechanism and clinical management. Chin Med J (Engl). 2023;136 (22):2668-76. DOI:10.1097/CM9.0000000000002906
2. Saleh K, Haldar S. Atrial fibrillation: A contemporary update. Clin Med (Lond). 2023;23 (5):437-41. DOM 0.7861 /clinmed. 2023-23.5.Cardio2 3. Yurkulueva GA, Donakanyan SA, Bokeria LA. Pathophysiological aspects of the development and preservation of atrial fibrillation. Annaly Aritmologii. 2023;20 (2):113-8.
4. Basieva MA, Kazanova PV, Shvartz VA. Role of chronic inflammation in the development of recurrent atrial fibrillation after interventional treatment. Annaly Aritmologii. 2024;21 (1):39-48.
5. Kazanova PV, Basieva MA, Shvartz VA. Immune remodeling in the pathogenesis of atrial fibrillation. Annaly Aritmologii. 2023;20 (2):119-30.
6. Abgaryan АА, Berdibekov BSh, Aleksandrova SA, et al. Prognostic role of left atrial fibrosis assessment using magnetic resonance imaging in patients with atrial fibrillation after catheter pulmonary vein isolation. Creative Cardiology. 2024;18 (1):92-103. DOI: 0.24022/1997-3187-2024-18-1-92-103 7. Meyre РВ, Sticherling С, Spies F, et al. C-reactive protein for prediction of atrial fibrillation recurrence after catheter ablation. ВМС Cardiovasc Disord. 2020;20 (1):427. DOI:10.1186/s12 872-020-01711-х
8. Guo Y, Lip GY, Apostolakis S. Inflammation in atrial fibrillation. J Am Coll Cardiol. 2012;60 (22):2263-70. DOI:10.1016/j. jacc. 2012.04.063
9. Patel P, Dokainish H, Tsai P, Lakkis N. Update on the association of inflammation and atrial fibrillation. J Cardiovasc Electrophysiol. 2010;21 (9): 1064-70. DOM0.1111/j.1540-8167.2010.01774.x
10. Zhao Z, Zhang X, Sun T, et al. Prognostic value of systemic immune-inflammation index in CAD patients: Systematic review and meta-analyses. Eur J Clin Invest. 2024;54 (2):e14100. DOI:10.1111/eci.14100
11. Chen YC, Liu CC, Hsu HC, et al. Systemic immune-inflammation index for predicting postoperative atrial fibrillation following cardiac surgery: A meta-analysis. Front Cardiovasc Med. 2024;11:1290610. DOI:10.3389/fcvm.2024.1290610
12. Shvartz VA, Le TG, Enginoev ST, et al. Association of new markers of systemic inflammation with the risk of developing for the first time postoperative atrial fibrillation when using colchicine in patients undergoing open heart surgery. Annaly Aritmologii. 2023;20 (1):22-33.
13. Omur SE, Zorlu С, Yilmaz М. Comparison of the relationship between inflammatory markers and atrial fibrillation burden. Anatol J Cardiol. 2023;27 (8):486-93. DOI: 0.14744/ AnatolJCardiol.2023.2927
14. Naser A, Sayilan S, Guven O, et al. Inflammation burden and atrial fibrillation burden: A bidirectional relationship. Arq Bras Cardiol. 2024;121 (6):e20230680. DOI: 0.36660/abc.20230680
15. Kaya H, Ertas F, islamoglu Y, et al. Association between neutrophil to lymphocyte ratio and severity of coronary artery disease. Clin Appl Thromb Hemost. 2014;20 (1):50-4. DOI: 0.1177/1076029612452116
16. Talibova SM, Basieva MA, Shvartz VA. The role of "novel" biomarkers of systemic inflammation in assessing the severity and course of coronary heart disease. Clinical Physiology of Circulation. 2023;20 (3):221-30. DOI: 0.24022/1814-6910-2023-20-3-221-230 17. Sagnard A, Hammache N, Sellal JM, Guenancia С. New perspective in atrial fibrillation. J Clin Med. 2020;9 (11):3713. DOM 0.3390/jcm9113713 18. Davtyan KV, Kalemberg AA, Tsareva EN, et al. The role of inflammatory theory in the pathogenesis of atrial fibrillation. Russian Journal of Cardiology. 2019; (7): 110-4. DOI: 0.1 5829/1560-4071-2019-7-110-114
19. Ihara К, Sasano Т. Role of inflammation in the pathogenesis of atrial fibrillation. Front Physiol. 2022;13:862164. DOI:10.3389/fphys.2022.862164

AttachmentSize
2025_01_037-043.pdf328.14 KB
All articles of the authors: Talibova S.M., Shvartz V.A., Kazanova P.V. , Ispiryan A.Yu., Filatov A.G. , Donakanyan S.A. , Basieva M.A., Avanesyan G.A.

No votes yet