

Contribution of professor Elena V Karyakina to the progress of Russian rheumatology
Heading: anniversary Article type:
Authors: Puchinyan D.M., Ulyanov V.Yu., Grishin S.E., Gladkova E.M.
Organization: Saratov State Medical University
The article follows all milestones of professor Elena V. Karyakina's scientific career. Her research of the connective tissue biochemistry and designing of medical technologies aimed at improving the efficacy of treatment and surgical management in patients with rheumatoid arthritis and osteoarthrosis of larger joints made a significant contribution to the development of Russian experimental and practical rheumatology.
Bibliography:
1. Grishin SE, Ulyanov VYu, Ostrovskij VV, et al., eds. Trau-matology and orthopedics in Saratov: history, traditions, achievements. Saratov: Saratov Medical University, 2021; Vol. II: 322 p.
2. Karyakina EV. Clinical significance of glycosaminoglycans determination in biofluids in rheumatoid arthritis. PhD abstract. Moscow, 1984; 22 p.
3. Method for determining sulfated glycosaminoglycans in biofluids. Inventor's Certificate USSR No. 1125548; IPC G01N 33/48. Karyakina EV, application №3628168; priority of July 25, 1983; published Nov. 23, 1984. Bull. №43.
4. Karyakina EV Endogenous intoxication and connective tissue metabolism disorders in patients with rheumatoid arthritis (pathogenetic mechanisms, diagnosis, treatment). DSc abstract. Moscow, 1998; 46 p.
5. Belova SV Peroxide-antioxidant imbalance in rheumatoid inflammation and it possible drug correction. PhD abstract. Saratov, 1999; 23 p.
6. Goryachev VI. Ceruloplasmin in complex treatment of rheumatoid arthritis patients. PhD abstract. Moscow, 1999; 25 p.
7. Karyakina EV, Belova SV, Goryachev VI. Ceruloplasmin — blood enzyme and drug. Saratov: Nauchnaya kniga, 2006; 139 p.
8. Gladkova EV Experimental rationale for the treatment of adjuvant arthritis with ceruloplasmin. PhD abstract. Saratov, 2000; 22 p.
9. A method for the treatment of adjuvant arthritis. Patent for invention №2156617; IPC A61 К 35/16 (RF). Karyakina E.V., Gladkov E.V (RF). Application №99111811/13, priority of June 03, 1999; published Sept. 27, 2000. Bull. №27.
10. Blinnikova VV Pathogenetic substantiation of local therapy for simulated adjuvant arthritis with sodium hyaluronate. PhD abstract. Saratov, 2006; 24 p.
11. Belova SV Metabolic state of connective tissue in physiologic norm and its regulation by natural compounds in simulated arthritis. DSc abstract. Astrakhan, 2013; 36 p.
12. Persova ЕА. Features of bone tissue remodeling in total hip arthroplasty, and their clinical and laboratory assessment. PhD abstract. Saratov, 2010; 27 p.
13. Konyuchenko E.A. Peroxide-antioxidant balance and humoral immunity in complicated cervical trauma. PhD abstract. Moscow, 2012; 25 p.
14. Karyakina EV, Gladkova EV, Puchinyan DM, et al. Structural and metabolic features of articular tissues in joint diseases. Saratov: Scientific Research Institute of Traumatology, Orthopedics and Neurosurgery, Federal State Budgetary Educational Institution of Higher Education VI. Razumovsky Saratov State Medical University: Innovative Medical Technologies LLC, 2020; 157 p.
15. Karyakina EV Sad Words: poems. Saratov, 2018; 144 p.
16. Karyakina EV Reflections on life: poems. Saratov, 2020; 75 p.
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