

Features of the dynamics of blood hemoglobin fractions in patients of the newborn and infancy periods
Heading: Рathophysiology Article type: Original article
Authors: Geraskin I.V., Trofimov V.A., Voennov O.V., Geraskina N.V., Geraskin V.A.
Organization: Privolzhskiy Research Medical University, Nizhny Novgorod Regional Children's Clinical Hospital, National Research Ogarev Mordovia State University, Institute of Medicine
Objective: to determine the dynamics of the levels of blood hemoglobin fractions and changes in their affinity for oxygen in the pathology of newborns and infants, the first months of life. Material and methods. The examination group included clinical data of 204 neonatal patients of neonatology and pediatric departments. 635 studies of changes in indicators of blood hemoglobin types were performed and 125 ratios of fetal hemoglobin (FHbF) with oxygen partial pressure values at 50% blood oxygenation (p50) were analyzed. The dynamics of replacement of blood hemoglobins has been studied, taking into account the dependence on age, gestation period, severity of diseases and intensity of oxygenotherapy. The data were obtained by analyzing medical histories in intensive care, pediatric departments — at the stages of the therapeutic and diagnostic process. Results. When comparing the indicators in the group of premature infants, there is a high level of FHbF — 74.8% and a relatively low level of p50-21.2 mm Hg. This combination forms an increase in the affinity of hemoglobin to oxygen and an increase in the release of oxygen in areas of tissue hypoxia and acidosis. Conclusion. In pathology in newborn children, the formation of the oxygen status of blood and its delivery to tissues occurs under conditions of constant variability in the composition of hemoglobins -in contrast to static indicators in infants.
Bibliography:
1. Singer D. [Surviving the lack: natural adaptations in newborns]. Z Geburtshilfe Neonatol 2021; 225 (3): 203-15.
2. Barbarani G, Labedz A, Stucchi S, et al. Physiological and aberrant y-globin transcription during development. Front Cell Dev Biol 2021; (9): 640060. DOI: 10.3389/fcell. 2021.640060. PMID: 33869190. PMCID: PMC8047207.
3. Henry ER, Metaferia B, Li Q, et al. Treatment of sickle cell disease by increasing oxygen affinity of hemoglobin. Blood 2021; 138 (13): 1172-81. DOI: 10.1182/blood. 2021012070. PMID: 34197597. PMCID: PMC8570057.
4. Geraskin VA, Potemina ТЕ, Geraskin IV, et al. Pathophysiological justification of the community of neonatal factorsofthe pathogenesisof hemolyticanemia and inflammation. Saratov Journal of Medical Scientific Research 2019; 15 (2): 372-6.
5. Pritisanac Е, Urlesberger В, Schwaberger В, Pichler G. Accuracy of pulse oximetry in the presence of fetal hemoglobin —A systematic review. Children (Basel) 2021; 8 (5): 361. DOI: 10.3390/children8050361. PMID: 33946236. PMCID: PMC8145233.
6. Shiffman FDzh. Pathological physiology of blood. Moscow: BINOM, 2019; 448 p.
7. Chegondi М, Ten I, Totapally В. Dapsone-induced methemoglobinemia in a child with end-stage renal disease: A brief review. Cureus 2018; 10 (4): e2513.
8. Tepaev RF, Vishnevsky VA, Kuzin SA, et al. Methemoglobinemia associated with benzocaine intake (Clinical case). Pediatric Pharmacology 2018; 15 (5): 396-401.
9. Gay НС, Amaral АР. Acquired methemoglobinemia associated with topical lidocaine administration: A case report. Drug Saf Case Rep 2018; 5 (1): 15.
10. Liu N, Xu S, Yao Q, et al. Transcription factor competition at the y-globin promoters controls hemoglobin switching. Nat Genet 2021; (53): 511-20.
11. Seeger C, Higgins О Laboratory indicators in emergency medicine. Denmark: Radiometer Medical ApS, 2014; p. 51 -6.
Attachment | Size |
---|---|
2022_3_394-398.pdf | 625.03 KB |