Saratov JOURNAL of Medical and Scientific Research

Testosterone deficiency in type 2 diabetes mellitus with varying degrees of carbohydrate metabolism compensation

Year: 2022, volume 18 Issue: №2 Pages: 223-226
Heading: Endocrinology Article type: Original article
Authors: Yesaulenko D.I., Rozhivanov R.V., Shishkina V.V., Zakurdaev V.A.
Organization: National Medical Research Center of Endocrinology, Voronezh State Medical University n.a. N.N. Burdenko

Objective: to evaluate total testosterone level in type 2 diabetes mellitus (DM) males with different degrees of compensation of carbohydrate metabolism. Material and methods. The continuous screening cross-sectional non-interventional study included 100 males at the age of 45 [43; 48] years primarily diagnosed with type 2 DM. The study lasted from February 2021 till May 2021. The level of glycated hemoglobin (HbA1c) and total blood testosterone were determined. Group comparison was performed with Mann —Whitney U-test, Kruskal—Wallis test and Fisher criterion. The differences were considered statistically significant atp<0.05. Results. When comparing patients with different levels of HbA1c, it was found that in patients with HbAlcfrom less than 6.5 to 9.9%, both total testosterone levels and the prevalence of its deficiency did not differ statistically significantly. At HbA1 с greater than 12%, the prevalence of testosterone deficiency increased statistically significantly (p<0.001) and testosterone levels decreased (p<0.001). Comparison of groups of patients with HbA1c levels from less than 6.5 to 9.9% and from 10 to 11.9% did not reveal statistically significant differences in the prevalence of deficiency and testosterone levels. However, there was a tendency to worse indicators in the latter group, especially since patients with HbA1c levels from less than 6.5 to 9.9% were older. Conclusion. Total testosterone level in type 2 DM patients are associated with compensation of carbohydrate metabolism. The negative impact on testosterone production was detected in patients with HbA1c level higher than 10%.

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