Testosterone deficiency in type 2 diabetes mellitus with varying degrees of carbohydrate metabolism compensation
Year: 2022, volume 18 Issue: №2 Pages: 223-226
Heading: Endocrinology Article type: Original article
Authors: Yesaulenko D.I., Rozhivanov R.V., Shishkina V.V., Zakurdaev V.A.
Organization: National Medical Research Center of Endocrinology, Voronezh State Medical University n.a. N.N. Burdenko
Heading: Endocrinology Article type: Original article
Authors: Yesaulenko D.I., Rozhivanov R.V., Shishkina V.V., Zakurdaev V.A.
Organization: National Medical Research Center of Endocrinology, Voronezh State Medical University n.a. N.N. Burdenko
Summary:
Objective: to evaluate total testosterone level in type 2 diabetes mellitus (DM) males with different degrees of compensation of carbohydrate metabolism. Material and methods. The continuous screening cross-sectional non-interventional study included 100 males at the age of 45 [43; 48] years primarily diagnosed with type 2 DM. The study lasted from February 2021 till May 2021. The level of glycated hemoglobin (HbA1c) and total blood testosterone were determined. Group comparison was performed with Mann —Whitney U-test, Kruskal—Wallis test and Fisher criterion. The differences were considered statistically significant atp<0.05. Results. When comparing patients with different levels of HbA1c, it was found that in patients with HbAlcfrom less than 6.5 to 9.9%, both total testosterone levels and the prevalence of its deficiency did not differ statistically significantly. At HbA1 с greater than 12%, the prevalence of testosterone deficiency increased statistically significantly (p<0.001) and testosterone levels decreased (p<0.001). Comparison of groups of patients with HbA1c levels from less than 6.5 to 9.9% and from 10 to 11.9% did not reveal statistically significant differences in the prevalence of deficiency and testosterone levels. However, there was a tendency to worse indicators in the latter group, especially since patients with HbA1c levels from less than 6.5 to 9.9% were older. Conclusion. Total testosterone level in type 2 DM patients are associated with compensation of carbohydrate metabolism. The negative impact on testosterone production was detected in patients with HbA1c level higher than 10%.
Bibliography:
1. Dedov II, Melnichenko GA, Shestakova MV, et al. Guidelines for the diagnosis and treatment of testosterone deficiency (hypogonadism) in male patients with diabetes mellitus. Obesity and Metabolism 2017; 14 (4): 83-92.
2. Ding EL, Song Y, Mafk VS, et al. Sex differences of endogenous sex hormones and risk of type 2 diabetes. A systematic review and meta-analysis. JAMA 2006; 295 (11): 1288-99. DOI: 10.1001/jama.295.11.1288.
3. Agarwal PK, Singh P, Chowdhury S, et al. A study to evaluate the prevalence of hypogonadism in Indian males with type-2 diabetes mellitus. Indian J Endocr Metab 2017; (21): 64-70. DOI: 10.4103/2230-8210.196008.
4. Beatrice A, Dutta D, Kumar M, et al. Testosterone levels and type 2 diabetes in men: current knowledge and clinical implications. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2014; (7): 481-6. DOI: 10.2147/DMSO.S50777.
5. Ho CH, Jaw FS, Wu CC, et al. The prevalence and the risk factors of testosterone deficiency in newly diagnosed and previously known type 2 diabetic men. J Sex Med 2015; 12 (2): 389-97. DOI: 10.1111/jsm. 12777.
6. Martins JM, Jorge MP, Martins CM, et al. Primary and secondary hypogonadism in male persons with diabetes mellitus. Int J Endocrinol 2021; (2021): 8799537. DOI: 10.1155/2021/8799537.
7. Cheung KKT, Luk AOY, So WY, et al. Testosterone level in men with type 2 diabetes mellitus and related metabolic effects: A review of current evidence. J Diabetes Investig. 2015; 6 (2): 112-23. DOI: 10.1111/jdi.12288.
8. Rozhivanov RV, Yesaulenko Dl, Kalinchenko SY The prevalence of hypogonadism in patients with diabetes mellitus type 2 (DMT2). In: Proceedings of the 5th world congress on the aging male, The Aging Male. Salzburg, 2006: 9 (1): 27. DOI: 10.1080/13685530500533303.
9. Wu FCW, TajarA, Beynon JM, et al. Identification of late-onset hypogonadism in middle-aged and elderly men. N Engl J Med 2010; 363 (2): 123-35. DOI: 10.1056/NEJMoa0911101.
10. Savel'eva LV, Rozhivanov RV, Shurdumova BO, Fadeev VV. Normogonadotropic hypogonadism in men with obesity. Obesity and Metabolism 2009; 3 (20): 39-42.
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