Saratov JOURNAL of Medical and Scientific Research

Genetic aspects of Parkinson's disease

Year: 2022, volume 18 Issue: №1 Pages: 155-159
Heading: Тhematic supplement Article type: Review
Authors: Shpileva S.A., Kalinin V.A., Poverennova I.E., Natalevich S.P.
Organization: Samara State Medical University

Objective: to analyze of genetic mutations in patients suffering from Parkinson's disease. To achieve this objective, domestic articles and dissertations were studied, as well as foreign literary sources placed in scientific databases such as PubMed and Medscape. The list of references consists of 25 scientific researchs published from 2015 to 2022. In a result of generalization and systematization of the data, it was found that mutations in different gene loci lead to different clinical phenotypes of Parkinson's disease, which can help predict the course of the disease. It was also determined that the mutation in the GBA gene is the most common genetic defect in the Russian population. Determination of genetic mutations that cause Parkinson's disease in real clinical practice will allow diagnosis and treatment of the disease at the premotor stage, especially in people with a burdened family history.

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