Saratov JOURNAL of Medical and Scientific Research
Home

Stable coronary heart disease and chronic periodontitis: clinical and microbiological parallels

Year: 2021, volume 17 Issue: №3 Pages: 527-531
Heading: Тhematic supplement Article type: Original article
Authors: Lipatova Т.Е., Eremin A.V., Lepilin A.V.
Organization: Saratov State Medical University
Summary:

Purpose: in patients with stable coronary heart disease (CHD) and chronic periodontitis (CP) of varying severity, to assess the clinical and laboratory status and endothelial functions in comparison with the clinical, instrumental and microbiological characteristics of the periodontium. Material and Methods. 120 patients with CHD and CP were examined; 55 were with CP without somatic pathology, 30 were with CHD and intact periodontal disease. Results. In CHD in combination with mild CP, the level of C-reactive protein (4.5±1.5 mg/l), indicators of endothelial functions (endothelin-1: 4.5±1.6 ng/ml; slCAM-1: 429.6±90.8 ng/ml; sVCAM-1: 932.2±137.4 ng/ml; endothelium-dependent va-sodilation (EDV): 9.5±1.9%), characteristics of common carotid artery intima-media thickness (CCA IMT): 0.8±0.3 mm correspond to those in CHD without CP. CHD in combination with moderate and severe CP is associated with more severe dyslipidemia, high levels of C-reactive protein (8.8±4.7 mg/L); endothelial dysfunction (endothelin-1: 5.8±1.9 ng/ml; slCAM-1: 489.7±98.1 ng/ml; sVCAM-1: 1012.5±184.6 ng/ml; EDV: 8.6±1.8%), increased CCA IMT: 0.90±0.20 mm. Conclusion. Stable coronary artery disease in combination with moderate and severe CP compared with coronary heart disease without CP and coronary heart disease with mild CP is associated with more severe dyslipidemia, vascular wall remodeling and endothelial dysfunction. Endothelial dysfunction in patients with coronary heart disease, like the activity of periodontitis, is associated with periodontal colonization by P. gingivalis and T. forsythia.

Keywords: coronary heart diseases, parodontitis

Bibliography:
1. Vos Th. GBD 2019 Diseases and Injuries: Collaborators Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. The Lancet 2020; 396: 1135-59.
2. Shalnova SA, Drapkina OM, Kontsevaya AV. Monitoring of risk factors for chronic non-communicable diseases in Russia: realities and prospects: Value for practice. Bulletin of Roszdravnadzor 2018; 1: 21-4.
3. Eremin AV, Lipatova ТЕ, Lepilin AV, et al. Assessment of cardiovascular risk factors in patients with chronic periodontitis. Saratov Journal of Medical Scientific Research 2020; 45-9.
4. Aarabi G, Heydecke G, Seedorf U. Roles of Oral Infections in the Pathomechanism of Atherosclerosis. Int J Mol Sci 2018; 19(7): E1978.
5. Eke PI, Thornton-Evans GO, Wei L, et al. Periodontitis in US Adults: National Health and Nutrition Examination Survey 2009-2014. J Am Dent Assoc 2018; 149 (7): 576-88.
6. Pejcic A, Kesic LJ, Milasin J. C-reactive protein as a systemic marker of inflammation in periodontitis. Eur J Clin Microbiol Infect Dis2011; (303): 407-14.
7. Sanz M, Marco Del Castillo A, Jepsen S, et al. Periodontitis and Cardiovascular Diseases: Consensus report. J Clin Periodontol 2020; 47: 268-88.
8. Bale BF, Doneen AL, Vigerust DJ. High-risk periodontal pathogens contribute to the pathogenesis of atherosclerosis. Postgrad Med J 2017; 93: 215-20.
9. Cairo F, Gaeta C, Dorigo W, et al. Periodontal pathogens in atheromatous plaques: A controlled clinical and laboratory trial. J Periodontal Res 2004; 39: 442-6.
10. Hansson GK, Libby P, Tabas I. Inflammation and plaque vulnerability. J Intern Med 2015; 278: 483-93.
11. Gomes MS, Blattner TC, Sant'Ana Filho M, et al. Can apical periodontitis modify systemic levels of inflammatory markers? A systematic review and meta-analysis. J Endoc 2013; 39: 1205-17.
12. Fentoglu O, Bozkurt FY. The bi-directional relationship between periodontal disease and hyperlipidemia. Eur J Dent 2008; 2: 142.

AttachmentSize
2021_03-1_527-531.pdf319.22 KB
All articles of the authors: Eremin A.V., Lepilin A.V., Lipatova Т.Е.

No votes yet