Saratov JOURNAL of Medical and Scientific Research

Phagocytic reactivity of neutrophils in peripheral blood of patients with infectious complications after total knee replacement

Year: 2021, volume 17 Issue: №3 Pages: 490-494
Heading: Рathophysiology Article type: Original article
Authors: Galashina Е.А., Babushkina I.V., Gladkova E.V., Shpinyak S.P., Ulyanov V.Yu.
Organization: Saratov State Medical University

Objective: to study phagocytic reactivity of neutrophils in peripheral blood of patients with infectious complications after total knee replacement. Material and Methods. We identified indicators of Phagocytic Activity of Neutrophils (PAN) in peripheral blood in 40 patients with implant-associated infection (main group) and 30 individuals without infectious inflammatory complications including aseptic loosening of knee implant components (comparison group). Results. In patients of the main group on the 5th day of the revision total knee replacement the increase in Phagocytic Index (PI) (p<0.05) was observed as well as in Phagocyte Index in 5 min Incubation (PI5) (p<0.05), Phagocyte Index in 30 min Incubation (PI30) (p<0.05), Phagocytosis Completeness Index (PCI) (p<0.05), and Number of Active Phagocytes (NAP) (p<0.05). In 14 days PI (p^O.05) and NAP (p.,<0.05) decreased as compared to the 5th day, while PI5 and PCI significantly increased. In patients of the comparison group PI (p<0.05), PI5 (p<0.05), and NAP (p<0.05) all grew by the 5th day. In 14 days PI30 grew (p^O.05) as compared to the day before. Conclusion. The incepting and digesting functions of neutrophils increased over 5 days in patients of the main group. On the 14th day we observed even higher incepting and digesting functions of neutrophils as compared to the 5th day. In patients of the comparison group the increase of incepting function of neutrophils was revealed over the 5th and 14th days of post-surgery.

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