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Accelerating regeneration of eye socket bone defect by modifying xenogenic elastin biomaterial

Year: 2021, volume 17 Issue: №2 Pages: 350-356
Heading: Тhematic supplement Article type: Original article
Authors: Lebedeva A.I., Shangina O.R., Nigmatullin R.T., Gareev E.M., Kutushev R.Z.
Organization: Bashkir State Medical University of the Russian Health Care, Russian Eye and Plastic Surgery Center
Summary:

Purpose: to identify the morphological aspects of the replacement of transplanted preserved and modified xenogenic elastin biomaterials in the rat eye socket defect. Material and Methods. Wistar rats were given a 7x4 mm defect in the upper wall of the eye socket. Wistar rats were treated with a 7x4 mm defect in the upper edge of the orbit. In the first experimental group (n=30), a preserved xenogenic elastin biomaterial (pXEBM) was placed in the defect zone, and in the second experimental group (n=30), a modified porous xenogenic elastin biomaterial (mXEBM) was placed. In the control group (n=30), soft tissues were sutured in layers. The tissues were excised after 1, 3, 6 and 12 months. Histological methods were used. Results. Grafts have osteoinductive, osteoconductive properties and are replaced by a full-fledged bone regenerate. After implantation, the mXEBM was replaced 2 times fasterthan the pXEBM. In the con- trol group, after 1 year, the bone defect did not spontaneously recover. Conclusion. Xenogenic biomaterials based on elastin are ultimate biomimetics. The porosity of the graft significantly accelerates the course of bone repair processes.

Keywords: regeneration, xenogenic elastin biomaterial

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