Features of intercellular interaction of platelets and neutrophils expressing adhesion molecules in psoriasis
Year: 2021, volume 17 Issue: №2 Pages: 236-240
Heading: Рathophysiology Article type: Original article
Authors: Sherstennikov N.V., Kashutin S.L., Sherstennikova A.K., Kalmin O.V., Nikolaev V.I.
Organization: North-West State Medical University n.a. I.I. Mechnikov, Department of Neuropathology Assistant Professor, Candidate of Medical Science, Penza State University
Heading: Рathophysiology Article type: Original article
Authors: Sherstennikov N.V., Kashutin S.L., Sherstennikova A.K., Kalmin O.V., Nikolaev V.I.
Organization: North-West State Medical University n.a. I.I. Mechnikov, Department of Neuropathology Assistant Professor, Candidate of Medical Science, Penza State University
Summary:
The aim of the study was to determine the features of intercellular interaction of platelets and neutrophils expressing adhesion molecules in patients suffering from psoriasis. Material and Methods. The study involved 82 patients aged 20 to 60 years, suffering from vulgar and exudative psoriasis. As a control group, 50 practically healthy persons aged from 20 to 60 years were examined. The study of the adhesion molecules spectrum on neutrophils was carried out on a Beckman Coulter FC-500 flow cytometer (USA) using monoclonal antibodies. The determination of neutrophils-platelet aggregates was carried out according to the method proposed by Y. A. Vitkovsky et al. (2006). Results. In patients with psoriasis, compared with the control group, a low content of intercellular contacts of neutrophils with platelets was revealed. Low values of neutrophils-platelet aggregates with 3, 4, and 5 segments in the nucleus, which were statistically significantly correlated with the adhesion molecules LFA-1 and PECAM-1, were found. Conclusion. In the conditions of psoriasis, low rates of intercellular interaction of platelets with 3, 4, and 5 segmental neutrophils indicate an increased migration of them from the peripheral blood to the epidermis. The adhesion molecules LFA-1 and PECAM-1 play a key role in the migration of platelet-derived neutrophils.
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