Antiphospholipid syndrome in a patient with myasthenia gravis: case report
Year: 2021, volume 17 Issue: №1 Pages: 148-151
Heading: Тhematic supplement Article type: Case report
Authors: Romanova T.V.
Organization: Samara State Medical University
Heading: Тhematic supplement Article type: Case report
Authors: Romanova T.V.
Organization: Samara State Medical University
Summary:
Patients with myasthenia gravis have an increased risk of other autoimmune diseases compared to population without myasthenia gravis. The development of two autoimmune diseases in one patient suggests common pathogenetic mechanisms. The article presents a case report of progression of antiphospholipid syndrome in a 44-year-old woman 12 years after onset of myasthenia gravis with an early onset and a high titer of antibodies to acetylcholine receptors, without a history of thymectomy This woman had a good obstetric history. She was diagnosed with antiphospholipid syndrome on the basis of clinical manifestations in form of ischemic stroke, and detection of high levels of antibodies to beta-2-glycoprotein-1 twice with an interval of 12 weeks. In the scientific literature there are limited cases of
Bibliography:
1. Sanadze AG. Myasthenia gravis and myasthenic syndromes. Moscow: GEOTAR-Media, 2017; 256 p.
2. Binks S, Vincent A, Palace J. Myasthenia gravis: a clinical-immunological update. Journal of Neurology 2015; 263: 826-34.
3. Nacu A, Andersen JB, Lisnic V, et al. Complicating autoimmune diseases in myasthenia gravis: a review. Review Autoimmunity 2015; 48 (6): 362-8.
4. Reshetnyak TM. Antiphospholipid syndrome: diagnosis and clinical manifestations (a lecture). Rheumatology Science and Practice 2014; 52 (1): 56-71.
5. Makarenko EV. Antiphospholipid syndrome. Problems of Health and Ecology. 2017; 4 (54): 4-11.
6. Yesaulenko IE, Kutashov VA, Ulyanova OV. Neurological presentations of a secondary antiphospholipid syndrome. Saratov Journal of Medical Scientific Research 2017; 13 (1): 139-43.
7. Dan D, Bart PA, Novy J, et al. Double seronegative myasthenia gravis with antiphospholipid syndrome: a case report. J Med Case Reports 2014; 8: 2.
8. Kaji M, Sato Y, Kunoh H, et al. Antiphospholipid syndrome and multiple ischemic strokes in a patient with myasthenia gravis. Kurume Med J 2002; 49 (4): 211-16.
9. Watanabe H, Hakusui S, Yanagi T, et al. A case of antiphospholipid syndrome associated with myasthenia gravis. Rinsho Shinkeigaku 1997; 377: 641-4.
10. Kulikova SL. Myasthenia gravis associated with primary antiphospholipid syndrome. Neurology and Neurosurgery in Belarus 2011; 2 (10): 147.
11. Danilo J, Diestro В, Dorotan MR, et al. Ischaemic stroke in a patient with myasthaenic crisis and antiphospholipid antibody syndrome. BMJ 2019; 12 (8): e231239.
| Attachment | Size |
|---|---|
| 2021_01-1_148-151.pdf | 294.82 KB |
Русский
English