Possibility of complex diagnostics of initial stages of osteoar-throsis
Year: 2020, volume 16 Issue: №2 Pages: 494-499
Heading: Traumatology and Orthopedics Article type: Original article
Authors: Romakina N.A., Gladkova Е.М., Titova Yu.I., Gladkova Yu.K.
Organization: Saratov State Medical University
Heading: Traumatology and Orthopedics Article type: Original article
Authors: Romakina N.A., Gladkova Е.М., Titova Yu.I., Gladkova Yu.K.
Organization: Saratov State Medical University
Summary:
Objective: To evaluate capabilities of magnetic resonance imaging including T2 relaxometry in combination with laboratory studies of biological markers for diagnostics of hyaline cartilage pathology in the initial stages of knee joint osteoarthritis (OA). Material and Methods: 37 patients of both sexes aged 35-50 years suffering from intermittent pain and discomfort in their knee joints (the main group). The control group was made up of 20 persons of the same age without clinical manifestations of joint pathology. Instrumental research included radiography, ultrasonography, and magnetic resonance imaging of knee joints, including T2 relaxometry measurement. The cartilage oligomeric matrix protein (COMP) content and daily urinary losses of C-terminal telopeptides of collagen type II Urine CartiLaps (CTX II) were determined. Inflammatory activity was evaluated by serum interleukin-1 (3 (11-1(3) with multiplex analysis and C-reactive protein concentration. Results: The increased content of cartilage extracellular matrix biopolymers in the biological fluids (serum COMP, urine excretion Urine CartiLaps (CTX II)) and inflammatory activity was found in patients of the main group compared to those in patients of the control group. Correlation between the COMP concentration and T2 relaxometry digital data (in CU) was characterized as positive strong (R = 0.83), and between COMP and articular cartilage thickness (in mm) on ultrasound data as negative medium (R = -0.63). Interconnections of the same kind were found between the level of daily excretion CTX II and articular cartilage morphometry findings with ultrasound (R = -0.59). Conclusion: Structural changes in the extracellular matrix in early stages of OA can be objectified using T2 cartilage relaxometry and determining COMP as well as CTX II in biological media.
Bibliography:
1. Alekseeva LI. Clinical guidelines update on the treatment of patients with osteoarthritis in 2019. Russian medical journal 2019; (4): 2-6.
2. Russian Clinical Guidelines. Rheumatology/Ed. Nasonova EL. Moscow: GEOTAR-Media, 2017; 464 p.
3. Samorodskaya IV. Advising osteoarthritis patients in accordance with new NICE recommendations. Russian medical journal. Rheumatology 2014; (31): 2170.
4. Rousseau JC, Delmas PD. Biological markers in osteoarthritis. Nat Clin Pract Rheumatol 2007; 3 (6): 346-56.
5. Li ZN, Wei XC. Diagnosis value of biological markers CTX-II in osteoarthritis. Zhongguo Gu Shang 2008; 21 (9): 719-22.
6. Nasnikova lYu, Morozov SP, Filisteev PA. Magnetic resonance tomography: quantitative assessment methods in articular cartilage structure analysis of in patients with osteoarthrosis. Russian electronic journal of radiology 2011; 1 (3): 75-81.
7. Stogov MV, Ovchinnikov EN. Laboratory tests in preclinical diagnosis of osteoarthrosis. An analytical review. Genij Ortopedii 2016; (1): 96-103.
8. Smith НЕ, MosherTJ, Dardzinski BJ. Spatial Variation in Cartilage T2 of the Knee. Journal of magnetic resonance imaging 2001; (14): 50-55.
9. Kabalyk MA, Gnedenkov SV, Kovalenko TS, et al. Molecular subtypes of osteoarthritis. Pacific Medical Journal 2017; (4): 40-4.
10. Kabalyk MA. Opportunities of magnetic resonance imaging in diagnosis of microstructural changes of articular cartilage in osteoarthritis. Perm medical journal 2018; 35 (3): 15-23.
11. Mustafin RN, Khusnutdinova ЕК Molecular Mechanisms of Osteoarthrosis. Medical care 2015; (3): 86-92.
12. Vila S. Inflammation in Osteoarthritis. Puerto Rico health sciences journal 2017; 36 (3): 123-9.
13. Gajdukova IZ, RebrovAP. Biomarkers in joint diseases, state of the problem and application perspectives. Scientific practical rheumatology 2012; 54 (5): 73-9.
14. Starodubtseva IA, Vasilieva LV. The comparative analysis of level of oligomeric matrix protein of cartilage in blood serum of patients with diseases of musculo-skeletal system. Russian Clinical Laboratory Diagnostics 2016; 61 (2): 83-6.
15. Hoch JM, et al. Serum cartilage oligomeric matrix protein (sCOMP) is elevated in patients with knee osteoarthritis: a systematic review and meta-analysis. Osteoarthritis Cartilage 2011; 19(12): 1396-1404.
16. Baum T, Joseph GB, Karampinos DC, et al. Cartilage and meniscal T2 relaxation time as non-invasive biomarker for knee osteoarthritis and cartilage repair procedures. Osteoarthritis Cartilage 2013; 21 (10): 1474-84.
17. Binks DA, Hodgson RJ, Ries ME, et al. Quantitative parametric MRI of articular cartilage: a review of progress and open challenges. Br J Radiol 2013; 86 (1023): 20120163.
18. Jungmann PM, Baum T, Bauer JS, et al. Cartilage Repair Surgery: Outcome Evaluation by Using Noninvasive Cartilage Biomarkers Based on Quantitative MRI Techniques? BioMed Research International 2014; Article ID 840170.
19. Mosher TJ, Dardzinski BJ. Cartilage MRI T2 Relaxation Time Mapping: Overview and Applications. Seminars in Musculoskeletal Radiology 2004; 6 (4): 355-68.
20. Abdel-Magied RA, Mohammed WF, Omar GMA, et al. Relation of osteopontine levels in plasma and synovial fluid of patients with knee osteoarthritis to magnetic resonance imaging findings of the knee joint. Int J Clin Rheumatol 2019; 14 (5): 216-24.
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