Saratov JOURNAL of Medical and Scientific Research

№2, 2018, volume 14

Clinical case of favourable outcome at a patient with eosinophilic granulomatosis with polyangiitis complicated by severe heart disease

Year: 2018, volume 14 Issue: №2 Pages: 207-209
Heading: Internal Diseases Article type: Case report
Authors: Alexandrova O.L., Skryabina E.N., Nikitina N.M., Romanova I.A., Alexandrova N.L.
Organization: Saratov State Medical University

The aim of the article is to present a clinical case of rapid generalization of eosinophilic granulomatosis with polyangiitis. The course of disease with multiple organ lesions and the heart being affected the most is described. Remission is achieved by combined therapy with corticosteroids and cyclophosphamide.

Keywords: eosinophilic granulematosis with polyangiitis, rapid generalization of disease, severe heart disease

Adipokines and their possible role in obesity and type 2 diabetes mellitus

Year: 2018, volume 14 Issue: №2 Pages: 201-206
Heading: Endocrinology Article type: Review
Authors: Kuznetsova L.A., Shpakov А.О.
Organization: I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Laboratory of Molecular Endocrinology and Neurochemistry

The adipose tissue is the endocrine organ secreting polypeptide factors, such as adipokines, which are involved in the regulation of feeding behavior, the metabolic, endocrine and inflammatory processes and insulin sensitivity. In obesity and type 2 diabetes mellitus (DM2), the production of adipokines and the activity of their signaling pathways are changed, which plays an important role in the relationship between obesity, insulin resistance and DM2. In the review (according the types of obesity) the data on the production of adipokines with diabetogenic (leptin, visfatin, chemerin, vaspin, apelin, resistin) and antidiabetic (adiponectin, omentin) properties by the adipose tissue, as well as the possible role of adipokines in the development of obesity and DM2 were discussed.

Keywords: insulin resistance, adipokines, type 2 diabetes

Gender and age peculiarities of aortic pressure in healthy adolescents

Year: 2018, volume 14 Issue: №2 Pages: 197-200
Heading: Physiology and Pathophysiology Article type: Original article
Authors: Sheveleva A.M.
Organization: Volgograd State Medical University

Aim: to reveal gender and age peculiarities of daily dynamics of systolic aortic pressure (SBPao), diastolic aortic pressure (DBPao), mean hemodynamic aortic pressure (MBPao) and pulse aortic pressure (PPao) in healthy adolescents. Material and Methods. Ambulatory blood pressure monitoring was performed in 354 healthy adolescents (184 girls, 170 boys) aged 12-17 years. Results. Daytime, nighttime and diurnal levels of SBPao and PPao were significantly lower in girls, than that of boys. Boys had significantly lower daytime and diurnal levels of DBPao than girls. Nighttime level of MBPao was significantly higher in boys than in girls. Growth positively correlated with daytime, nighttime and diurnal levels of SBPao (r=0.3, r=0.4and r=0.4 respectively) in boys 12-17 years old. Correlation analysis in girls 12-17 years showed a weak positive relationship between growth and nighttime, daytime and diurnal levels of SBPao (r=0.14, r=0.2 and r=0.14 respectively). Conclusion. The observed differences between age subgroups could be associated with the different velocity of pubertal development in the examined adolescents, as well as with the different role of hormonal and neuronal regulation mechanisms in the formation of aortic pressure level and its diurnal dynamics.

Keywords: adolescents, aortic pressure