Saratov JOURNAL of Medical and Scientific Research

Adipokines and their possible role in obesity and type 2 diabetes mellitus

Year: 2018, volume 14 Issue: №2 Pages: 201-206
Heading: Endocrinology Article type: Review
Authors: Kuznetsova L.A., Shpakov А.О.
Organization: I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Laboratory of Molecular Endocrinology and Neurochemistry

The adipose tissue is the endocrine organ secreting polypeptide factors, such as adipokines, which are involved in the regulation of feeding behavior, the metabolic, endocrine and inflammatory processes and insulin sensitivity. In obesity and type 2 diabetes mellitus (DM2), the production of adipokines and the activity of their signaling pathways are changed, which plays an important role in the relationship between obesity, insulin resistance and DM2. In the review (according the types of obesity) the data on the production of adipokines with diabetogenic (leptin, visfatin, chemerin, vaspin, apelin, resistin) and antidiabetic (adiponectin, omentin) properties by the adipose tissue, as well as the possible role of adipokines in the development of obesity and DM2 were discussed.

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