2010, volume 6

Pharmacoeconomic parameters have been examined in patients with ischemic stroke who have suffered from arterial hypertension, depending on use of antihypertensive therapy. The role of antihypertensive therapy as a factor that significantly reduces the treatment costs and improves stroke outcome has been proved. The research results show the importance of integrated analysis of clinical and economical factors in the treatment of patients with arterial hypertension

The aim of research was to study clinical and morphological features of peptic ulcer at men and women of various age.
166 patients with duodenal peptic ulcer (80 men and 86 women) and 138 with stomach peptic ulcer (80 men and 58 women) were inspected. Clinical displays, morphometrical analysis of components of diffuse neuroendocrine system and stomach receptors of sexual hormones were studied.
It is defined, that peptic ulcer at women under 40 years has more favorable clinical current, than at men. This is based on local neuroendocrine status with positive shifts of melatonin-, VEGF-, glucagon-like cells. In patients aged upwards 40 clinical features of disease course, local neuroendocrine status are erased both at men and women. In patho-genesis of peptic ulcer infringement of receptors expression of steroid hormones in stomach with hyper expression of androgen receptors at men or decrease in receptors expression of estrogen and progesterone along with increase of expression of androgen receptors at women matters.
Forecasting of peptic ulcer can be based not only on traditional criteria, but also on results of dynamic research of androgen receptors expression (at men), androgen-, estrogen and progesterone receptors (at women)

The article reviews the results of observation of 439 patients between 1 and 18 years of age with EBV mononucleosis. The detailed analysis of clinical laboratory peculiarities of primary infection and its reactivation in patients of different age is also supplemented by the overall evaluation of the rehabilitation period in dependence on age and type of infection.

The research objective is to work out the creation of Russian-language questionnaire for assessing quality of life of patients with chronic urticaria by adapting the questionnaire «Chronic Urticaria Quality of Life Questionnaire» (CU-Q2oL) to Russian conditions. The study involved 150 patients aged 18 to 50 years (32,41±6,02) with chronic urticaria. Cultural and linguistic adaptation of the questionnaire was conducted according to international methodology. Evaluation of reliability was conducted by calculating Cronbach's б-coefficient, constructive validity -the method of «known groups» and the identification of mutual correlations with the scales of the SF-36 questionnaire, sensitivity-by comparing the quality of life before and after the treatment. High values of Cronbach's б-coefficient (>0.72) were obtained, the dependence of quality of life on the severity of chronic urticaria was proved to be significant, as well as the sensitivity of the questionnaire to clinical changes. The research findings confirmed good psychometric properties of Russian version of the questionnaire. The developed version of the questionnaire is a reliable, valid and sensitive device for assessing the quality of life in patients with chronic urticaria, and may be used in scientific and clinical research.

In the literary review frequency, risk factors, reasons and mechanisms of perioperative complications occurrence are submitted at thorax and abdominal interventions, including common data, cardiovascular complications, data about massive blood loss, condition of respiratory system, hemostasiologic complications; reasons of complications development are specified, consequences of inadequate anesthesia are named, mechanisms of perioperative complications development and consequence of a protein-power failure are considered

The aim of this research is to study influence of cerebral perfusion pressure on the effectiveness of treatment of maternity patient in eclamptic coma. Fluctuation of average arterial pressure defines dynamics of the cerebral perfusion pressure. Active hypotensive therapy leads to reduction of cerebral blood flow, breaking perfusion balance of brain. The principal objective of treatment in eclamptic coma is to restore volemic indices by using stabizol, decrease of average arterial pressure (10-15% from the initial one), which is provided by magnesium sulfate and nimodipine. Providing the cerebral perfusion pressure above the level of 75 mm for maternity patient in eclamptic coma allowed to reduce lethality from 15,7 to 4,8%

The article represents modern data of aetiology and pathogenesis of tumor growths and benign ovarian tumors as systemic diseases of organism. These diseases appear on the cellular level and involve the presence of polymorphous metabolic, endocrine and immune disorders. Exogenous and endogenous risk factors of ovarian carcinomas are considered

The effect of progesterone and utrogestan on protein synthetical, fermentative and chromogenic functions of liver in patients with dysfunctional uterine bleedings (DUB) has been studied. 106 women ages 18 to 44 years with hormonal insufficiency of ovarial yellow bodies were examined. The functional condition of the liver was estimated through the content of protein, albumin, globulin, general bilirubin and its connective and free fractions, alanin - and aspartatami-notrasferase, gammaglutamiltranspeptidase, phosphatase alkaline, general and nonprotein sulfhydric groups in blood. The general and effective concentration of albumin was defined in blood serum. It is shown that the concentration of general protein, albumin, general and nonprotein sulfhydric groups decreased by the increased activity of indicated enzymes in patients. It was accompanied by endogenic intoxication. Progesterone treatment decreased the activity of protein synthetical function of liver reducing endocellular fermentative reactions and increasing the level of endogenic intoxication. Therapy by utrogestan resulted in hyperfermentation in patients with endotoxicosis and hypoproteinemia. Therefore patients with DUB suffered from disorders in metabolic function of liver

Placental insufficiency represents a syndrome of multifactorial etiology caused by morphological and functional changes in placenta, leading to disturbances in growth rates and development of fetus. Fetoplacental insufficiency is the leading factor in occurrence of fetal hypoxia, arrested development of fetus, traumas during delivery, diseases and complications in postnatal period. Placental insufficiency development is accompanied by disorders in differentiation and extension placental villi. Also processes of angiogenesis are affected. As a result there is a transport, respiratory, trophic, endocrinal and protective dysfunction of placenta. In fetal organism universal adaptative reactions directed on maintenance of homeostasis arise. Application of interval hypoxic therapy is directed on «training» of fetal adaptative mechanisms to hypoxia. Good tolerance of 10% О - gas mix has been revealed. High therapeutic effect is shown by increase in functional reserves of cardio-respiratory system, normalization of acid-base balance, normalization of arterial pressure, mobilization mechanisms of regulation of hypothalamic-pituitary adrenocortical system that results in increase of general resistance of fetus to hypoxia

The correlation between fetal hypoxia degrees according to the data of cardiotocography and status of mother's vegetative nervous system as a result of heart rhythm variability research have been analyzed. It has been revealed that during the increase of fetal hypoxia severity, mother has observed activation of sympathetic section of vegetative nervous system, which has changed by vagotonia in severe and terminal states. These findings can be used both for indirect estimation of fetal hypoxia severity and for its course prognosis