Saratov JOURNAL of Medical and Scientific Research


Year: 2006, volume 2 Issue: №3 Pages: 46-52
Heading: Internal Diseases Article type: Review
Authors: Smolyaninov A., Kirillov D., Bulgin D., Kovanko G.
Organization: St. Petersburg Medical University named after academician I.P.Pavlov

Heart diseases, and firstly ischemic heart disease and myocardial infarction, cause cardiomyocites death in the way of necrosis and apoptosis. Ability of myocardium to in self-renewing and regeneration is limited, the same way as therapeutically possibilities of prevention it`s remodeling. This loss of cardiomyocites is the leading factor of decrease of pumping function of heart and formation of chronically heart failure and dilated cardiomypathy. Limited ability of human cardiomyocites in proliferation and regeneration can not prevent scar formation and decrease of contractile ability after myocardial infarction. Substitution and regeneration of myocardial structures is significant purpose, it can be reached in the way of stimulation of auto logical cardiomyocites or transplantation of stem cells or skeletal myoblasts. Realization of the fact that myocardium has ability to regenerative process, conditioned in last years generate interest in using stems cells in cardiology. The way of using of stem cells in treatment cardio-vascular disease is aggressively developing in last ten years. In this period experimental outcomes were very convincing, and so this approach start to use in clinical practice.

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