Saratov JOURNAL of Medical and Scientific Research

АНТИМИКРОБНАЯ АКТИВНОСТЬ ПРОИЗВОДНЫХ ЦИКЛОГЕКСАНОЛА И 5 – НИТРОТИОФЕНОВОГО АЛЬДЕГИДА (RUS)

Year: 2006, volume 2 Issue: №2 Pages: 63-66
Heading: Microbiology Article type: Original article
Authors: O.G. Shapoval, L.A. Popaduk, Yu.A. Fomina, A.G. Golikov
Organization: Saratov State Medical University, Saratov National Research University n.a. N. G. Chernyshevsky
Summary:

Antimicrobial activity of new heterocyclic compounds on standart strains grampositive Staphylococcus aureus ATCC 29213 and gramnegative – Esherichia coli ATCC 25992 (M-17) Proteus mirabilis 20 was study/
Compounds №6 and №7 have shown high overwhelming action (minimum inhibitory concentration – MIC 39,58 +/- 6,8mkg/ml accordingly. This lower exceeds MIC of ceftrixon in two times ( MIC 39,58+/- 6,8 mkg/ml) and is near to MIC of furamag (11,51/-0,99 mkg/ml).
Compounds №6 activity on methicillinsesitive strains Staphylococcus aureus was two times higher (MIC 12,4 /- 4,34) than on methicillinstable strains Staphylococcus auerus (MIC 25,6+/- 5,02 mkg/ml). Antimicrobial action of compound №7 was the same both on methicillinstable strains (MIC 17,3+/-1,77 mkg/ml) and on methicillinsensitive strains (MIC 12,53+/-3,78 mkg/ml) Staphylococcus aureus. The same regularity was mark for chemical furamag. Activity of chemical ceftriaxon on methicillinstable strains Staphylococcus aureus was greatly lower.

No votes yet