Saratov JOURNAL of Medical and Scientific Research

Interrelation of cytokine profile and cytolysis in children with chronic virus hepatitis В

Year: 2011, volume 7 Issue: №2 Pages: 461-465
Heading: Pediatrics Article type: Original article
Authors: Keltsev V.A., Churbakova О.V.
Organization: Samara State Medical University

Chronic hepatites for today remain the important problem with children among children»s infections not only in our country, but also all over the world. In clause the immune factors influencing on патогенез of a chronic virus hepatites В at children are considered. The purpose of our job was studying interrelation cytolysis and a structure of cytokines at children sick of a chronic virus hepatites В Century. Material, methods. We have carried out research a structure of cytokines at 87 children with CVH В in the age of from 7 months till 18 years. Clinical supervision and researches with application general-clinical, biochemical, tool, immunological the methods have been spent, allowing to receive the fullest and objective information on the observable children sick CVH. Results. If to compare parameters cytokines in replicative and integration phases at a chronic virus hepatites В at children it is necessary to note, that in replica-tive a phase the basic parameters are aggravated. The conclusion. It speaks that in replicative phase CVH disease more hard proceeds. The deviation of level FNO-a, IL-1, IL-10 cytokines in whey of blood of patients with CVH В from normal parameters is the indicator of gravity of inflammatory process

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