Saratov JOURNAL of Medical and Scientific Research

Samara State Medical University

Factor analysis of IQ of children born to mothers with epilepsy

Year: 2020, volume 16 Issue: №1 Pages: 408-416
Heading: Neurology Article type: Original article
Authors: Yakunina A.V., Poverennova I.E., Kalinin V.A., Ananyeva S.A., Korobov G.D., Mazankina E.V.
Organization: Samara State Medical University, Vitebsk State Order of Peoples Friendship Medical University
Summary:

Objective: to investigate the intelligence quotient (IQ) in children born to mother with epilepsy; to analyse possible factors affecting childhood IQ. Material and Methods. The Wechsler test (WAIS for adults and WISC for children) examined 47 pairs of "a mother with epilepsy — her child". Twelve women did not take antiepileptic drugs, 24 had monotherapy, 11 had polytherapy Treatment with valproic acid (VK) was received during pregnancy by 23 women (48.9%). Statistical processing was carried out by the method of correlation (according to Pearson) and variance (according to Fisher) analysis, by the method of "classification trees" CART. Results. The average indicators of the general, verbal and non-verbal IQ of children amounted to 118.7 points (Cl09579.5-158.0); 106.3 (Cl 67.7-144.9) and 128.0 points (Cl 93.2-162.7). The correlation between the age of the mother, taking VC and the level of IQ of the child was revealed. Univariate analysis of variance did not reveal the effect of the treatment regimen (mono-, polytherapy, without antiepileptic drugs, using VK, without VK) on the total IQ of the child (p>0.05), but a decrease in IQ was found in children who were brought up in single-parent families. Multifactor analysis showed that a decrease in the total IQ of the child is most likely to occur with the use of VK drugs in mothers with a total IQ level below 113 and at the age of the child's birth >32 years of age. Conclusion. Children of women with epilepsy are characterized with normal IQ level. When planning pregnancy, it is necessary to consider factors that affect the IQ of the offspring.

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Rehabilitation potential of patients with myasthenia gravis

Year: 2020, volume 16 Issue: №1 Pages: 371-377
Heading: Neurology Article type: Original article
Authors: Romanova T.V., Kalashnikova V.V., Romanov D.V.
Organization: Samara State Medical University
Summary:

Objective: to identify individual psychological characteristics that determine the rehabilitation potential of patients with myasthenia gravis. Material and Methods. A homogeneous group of patients was included in the examination in order to level the effect of the severity of the condition on the results obtained. We examined 25 patients with a generalized form of myasthenia gravis who were in a stable compensated state. The methodology "Rehabilitation Potential of Personality" was used. Quality of life was investigated using the SF-36 questionnaire. Results. Patients were divided into two subgroups according to their subjective assessment of quality of life. First subgroup consisted of patients with low values of the psychological component of quality of life (15 people); second subgroup consisted of patients with indicators on this scale similar to control group (10 people). Main indicators of "Rehabilitation Potential of Personality" questionnaire were compared in two subgroups and a correlation analysis of parameters of SF-36 questionnaire and indicators of rehabilitation potential was carried out. Conclusion. The psychological component of quality of life of patients with myasthenia is most dependent on internal picture of disease and emotional state. By providing targeted psychocorrectional effects, it is possible to increase patient's rehabilitation potential.

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The use of virtual reality in the rehabilitation of stato-locomotor function after acute stroke (review)

Year: 2020, volume 16 Issue: №1 Pages: 363-367
Heading: Neurology Article type: Review
Authors: Poverennova I.E., Zakharov A.V., Khivintseva E.V., Lakhov A.S., Sheludiakova D.K.
Organization: Samara State Medical University
Summary:

The review presents the results of studies evaluating the eectiveness and safety of rehabilitation using virtual real- ity to restore stato-locomotor function in patients at dierent periods after suering an acute cerebrovascular accident. The analysis of works published for the period 2011–2019 and available for study according to the main scientic data- bases: MEDLINE (Ovid), Amed, EMBASE, CINAHL and PsycINFO.

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Features of examination and surgical treatment of patients with trigeminal neuralgia

Year: 2020, volume 16 Issue: №1 Pages: 347-352
Heading: Neurology Article type: Original article
Authors: Kamadey О.О., Poverennova I.E., Alekseev G.N., Lazarchuk D.M., Ikromova D.R.
Organization: Samara Municipal Hospital №1, Samara Regional Hospital, Samara State Medical University
Summary:

Purpose: introduction of the examination protocol into neurosurgical practice and evaluation of the results of micro-vascular decompression of the trigeminal nerve root in patients with type I trigeminal neuralgia. Material and Methods. The results of 86 operations of microvascular decompression of the trigeminal nerve root in patients with primary trigeminal neuralgia were studied. The preoperative examination protocol for all patients included a general clinical examination, assessment of neurological status, brain MRI with contrast enhancement and a cranial nerve imaging program (CISS or FIESTA). Particular attention was paid to the criteria for the diagnosis of trigeminal neuralgia type I (classical), recommended by the International Headache Society (IHS) in the International Classification of Headache Disorder (ICHD-3, 2018). The pain syndrome was evaluated according to the Visual Analogue Scale (VAS)from 0 to 100 points before surgery, at the time of discharge of the patient from the hospital, after 6 months and after 1 year. Microvascular decompression was performed according to a standard technique using, in all cases, a retrosigmoid suboccipital access, under general anesthesia. A Russian-made fluoroplastic felt was used as a tread. In most cases (98%), the main surgical techniques for isolation of the trigeminal root were used. Results. The effectiveness of surgical treatment was 95% Conclusion. Patients with a diagnosis of trigeminal neuralgia require examination according to a specific protocol that allows you to determine the indications for surgical treatment. The expediency of surgical intervention (microvascular decompression of the trigeminal nerve root) in patients with type I trigeminal neuralgia has been shown.

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Preliminary results of study on efficacy of a virtual reality technique for restoration of lower extremity motor function in patients in acute stage of stroke

Year: 2019, volume 15 Issue: №1 Pages: 172-176
Heading: Neurology Article type: Original article
Authors: Poverennova I.E., Zakharov A.V., Khivintseva E.M., Pyatin V.F., Kolsanov A.V., Chaplygin S.S., Osminina E.A., Lahov A.S.
Organization: Samara State Medical University
Summary:

Objective: to study efficacy of using immersive virtual reality with proprioceptive sensory effects in the rehabilitation of static locomotor function in patients in acute stage of ischemic stroke. Material and Methods. The study included 33 patients in the acute stage of ischemic stroke in the carotid system. Patients were randomized into two groups, the main group additionally took exercises in immersive virtual reality with sensory stimulation. The course includes 10 sessions 15 minutes each. The comparison group received standard rehabilitation assistance. Results. According to Berg balance scale an improvement in static locomotor function was noted in the main group on the 6th day of exercises (p=0.03). The differences between both groups on the last day of rehabilitation course showed an

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Autonomic dysfunction in patients with chronic cerebral ischemia

Year: 2019, volume 15 Issue: №1 Pages: 167-172
Heading: Neurology Article type: Original article
Authors: Poverennova I.E., Khivintseva E.V., Zakharov A.V., Vasemazova E.N., Ananyeva S.A.
Organization: Samara State Medical University
Summary:

Various autonomic nervous system (ANS) disorders exist in 25-80% of the general population. Seniors affected by chronic cerebral ischemia (CCI) are subject to the development of autonomic disorders. Purpose: to carry out the analysis of autonomic dysfunction in subjects with CCI. Material and Methods. Autonomic status was evaluated using autonomic function tests. All patients underwent cardiointervalography. Heart rhythm variability was estimated by mode, amplitude, variation range, power of waves of various frequency, coefficient of vagosympathetic balance etc. as measured by "Rhythm-MET" system. One hundred fifty one patients aged 48-93 years were examined and distributed to three groups depending on the degree of severity of CCI. Results were statistically processed using Statistica 6 software. Results. Patients with CCI had differences in autonomic function parameters which had multidirectional character and were dependent on sympathetic-parasympathetic balance and CCI stage. The obtained data demonstrate that prevalence of sympathetic influence was observed in 52.8% patients with I grade CCI, in 64.8% patients with II grade CCI and prevalence of parasympathetic

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Migraine and epilepsy: comorbidity and problems in diagnostics

Year: 2019, volume 15 Issue: №1 Pages: 154-158
Heading: Neurology Article type: Review
Authors: Kalinin V.A., Poverennova I.E., Yakunina A.V., Myakinina A.E.
Organization: Samara State Medical University
Summary:

The purpose of this review is to carry out the analysis of published data on comorbidity of migraine and epilepsy. The review is based on results of epidemiological and genetic studies. Clinical manifestations of two diseases are in many respects similar, which sometimes leads to considerable difficulties in diagnostics. Differential diagnosis is based on careful analysis of clinical manifestations, electroencephalography and neuroimaging data. Genetic forms of epilepsy are often accompanied by migrainous headaches. The unity of some pathophysiological mechanisms of epilepsy and migraine predefines comorbidity and directions of diagnostics and treatment for both diseases. Nevertheless, there is a number of questions which demand more precise answers to improve diagnostics and treatment.

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Influence of drinking behavior on the content of alpha-amylase of oral fluid in students with and without predictor of inflammation on the background of educational stress

Year: 2019, volume 15 Issue: №1 Pages: 9-13
Heading: Physiology and Pathophysiology Article type: Original article
Authors: Baisheva GM, Melnik KN.
Organization: Togliatti Clinical Hospital №5, Samara State Medical University
Summary:

 The aim: to study the content of a-amylase in oral fluid in healthy young people (mean age 18 years), depending on the presence of a predictor of inflammatory diseases of the oral cavity in physiologically adjusted drinking behavior against the background of educational stress. Material and Methods. For three months, we studied three groups: the main group (30 people, consumed water 30-35 ml per 1 kg of body weight treated with the electromagnetic device), a placebo group (30 people used water 30-35 ml per 1 kg of body weight, but consumed water with a placebo device that does not have an electromagnetic base) and a control one (25 people who do not change their water drinking behavior). To identify the features of sAA oscillations, all groups were divided into subpopulations with predictors of inflammatory diseases of the oral cavity (IL-1(3>212 pg/ml) and without such status (IL-1(3<212 pg/ml). The level of a-amylase activity was determined by a colorimetric method on Cobas C111 automated equipment (Roche), the concentration of IL-1J3 was detected by ELISA on an Infinity F50 photometer (Tecan). Results. Secretory alpha-amylase activity by the end of the study decreased in the main group; in the placebo and control groups, baseline values were exceeded. In the subpopulations with predictors of inflammatory dental diseases (IL-1(3<212 pg/ml) of the main group, the sAA activity decreased by 2.5 times; in the subpopulations without predicates of inflammatory changes (IL-1(3 <212 pg/ml), a significant decrease in enzyme activity in the main group was observed and an increase in the control. The percentage of sympathotonics at the end of the experiment in the main group was lower than in the placebo and control groups. Conclusion. A relation was found between a decrease in the level of a-amylase activity in the oral fluid and corrected water drinking behavior in a subgroup of people without predictors of inflammatory diseases of the oral cavity, using water in an amount of at least 30-35 ml/kg body weight that was purified by an electromagnetic method.

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Analysis of working conditions of employees of Samara medical institutions

Year: 2018, volume 14 Issue: №3 Pages: 427-433
Heading: Hygiene Article type: Original article
Authors: Tupikova D.S.
Organization: Samara State Medical University
Summary:

Objective: an analysis of the conditions and nature of the work of public health workers in the city of Samara, according to their own research and the results of a special assessment of working conditions for the development of preventive measures. Material and Methods. The study analyzed the results of assessing the factors of the production environment, such as microclimate and illumination in 70 rooms of two large medical institutions of the city of Samara. An estimation of the qualitative and quantitative microbial composition of the air medium in the analyzed rooms was carried out. The analysis of registration cards for a special assessment of the working conditions of workplaces in the same organizations was carried out between 2012 and 2017. Results. In analyzing the conditions and nature of the work of medical workers, it was revealed that the final class of working conditions for doctors and nurses of surgical departments was 3.3, therapeutic 3.2 as a result of biological factors. At the same time, the air in the working area of the study rooms of the surgical and therapeutic sections differed significantly in the structure of the conditionally pathogenic microflora. Physical and chemical factors did not exceed the level of class 3.1-3.2. Conclusion. An analysis of the results of the studies showed the need to optimize ventilation in the residents and nurses, as well as the need to improve the quality of natural and artificial lighting. The expediency of standardization of the conditionally pathogenic microflora of the air environment in class «B» premises is shown.

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Dynamics of acetylcholine receptors antibody titer in myasthenia gravis

Year: 2018, volume 14 Issue: №1 Pages: 164-168
Heading: Neurology Article type: Original article
Authors: Romanova T.V., Poverennova I.E., Zakharov A.V.
Organization: Samara State Medical University
Summary:

The aim was to examine the longitudinal association between myasthenia gravis clinical severity and concentration of acetylcholine receptor (AChR) antibodies to evaluate if AChR-antibody variations correlate to disease severity. Material and Methods. Antibodies were determined by enzyme immunoassay. The International Clinical Classification (MGFA) was used to grade the severity of the disease. The level of antibodies was compared with the severity of the condition and the form of the disease at the stage of diagnosis in 65 patients, as well as in repeated studies in 26 patients. Results. The titer of AChR-antibodies did not correlate with the severity of the condition, however, a direct relationship between the change in the level of acetylcholine receptor antibodies and the change in the clinical state during the course of the disease was obtained. Conclusion. Repeated AChR-antibody measurements will help to predict the clinical state of the patient and can be used to correct immunosuppressive therapy.

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