Saratov JOURNAL of Medical and Scientific Research

Features of the clinical course of gastroesophageal reflux disease associated with obesity

Year: 2018, volume 14 Issue: №1 Pages: 42-45
Heading: Internal Diseases Article type: Original article
Authors: Andreeva E.l.
Organization: Stavropol State Medical University

The research goal is to reveal the features of clinical manifestations of gastroesophageal reflux disease (GERD) in obesity. Material and Methods. A survey and anthropometric study of 51 patients suffering from GERD and obesity aged 30 to 60 years were conducted. The average age of the patients was 42.3±2.11 years. Patients were divided into groups according to the BMI score. The control group consisted of patients suffering from GERD without obesity. Results. The main complaint of the patients of the control group was heartburn, while the patients of the main group had complaints of dyspeptic nature. With an increase in BMI, there was an increase in the incidence of complaints, in addition, complaints of an extra-esophageal nature associated with the direct effect of acidic gastric contents on the pharyngeal mucosa were detected. This regularity is explained in the article by pathogenetic mechanisms of GERD development. In patients suffering from GERD without obesity, the development of the disease is caused by a change in the motor activity of the esophagus due to a decrease in the tone of the lower esophageal sphincter, and in patients with co-pathology the main role is given to increased intragastric pressure, which leads to disruption of the sphincter. Conclusion. Thus, the clinical picture of combination of GERD and obesity differs atypical for GERD current, the main features of which are the predominance of dyspeptic complaints, motor-evacuation disorders, and the presence of extraesophageal complaints.

1. Ivashkin VT, Lapina TL. Gastroenterology: National manual, short edition. Moscow: GEOTAR-Media, 2011; 480 p.
2. Lazebnik LB. Gastroesophageal reflux disease. Moscow: Medpraktika-M, 2012
3. Lazebnik LB, Bordin DS, Kozhurina TS. Patient with heartburn: tactics of a general practitioner. Lech Vrach 2009; (7): 5-8
4. Lazebnik LB, Masharova АА, Bordin DS. Results of a multicentre study «Epidemiology of gastroesophageal reflux disease in Russia» (MEGRE). TerArkh 2011; (1): 45-50
5. Mocanu MA, Diculescu М, Dumitrescu М. Gastroesophageal reflux and metabolic syndrome. Rev Med Chir Soc Med Nat lasi 2013 Jul.-Sep.; 117 (3): 605-609
6. Vasil'ev YuV. Gastroesophageal reflux disease: pathogenesis, diagnosis, medication. Consilium medicum 2002; 4 (9): 33-42
7. Zvenigorodskaya LA, Bondarenko EYu, Churikova AA, Mishchenkova TV. Gastroesophageal reflux disease in patients with obesity (clinic, diagnosis, treatment): Methodical recommendations. Moscow, 2011; 13 p.
8. Lazebnik LB, Zvenigorodskaya LA. Metabolic syndrome and digestive system. Moscow: Anakharsis, 2009; 184 p.
9. Drahos J, Ricker W, Parsons R, et al. Metabolic Syndrome Increases Risk of Barrett Esophagus in the Absence of Gastroesophageal Reflux: An Analysis of SEER-Medicare Data. J Clin Gastroenterol 2015, 49 (4): 282-288
10. Jacobson ВС, Somers SC. Association between body mass index and gastroesophageal reflux symptoms in both normal weight and overweight woman. N Engl J Med 2006; 354 (22): 2340
11. Zvenigorodskaya LA, Bondarenko EYu, Khomeriki SG. Clinical and morphological features of gastroesophageal reflux disease in patients with abdominal obesity. Consilium medicum. Gastroenterologiya 2010; 12 (8): 5-9
12. Ivashkin VT, Trukhmanov AS. Evolution of ideas about the role of disorders of esophagus motor function in the pathogenesis of gastroesophageal reflux disease. Journal of gastroenterology, hepatology and coloproctology 2010; 20 (2): 13-19
13. Roshchina TV Supra Esophageal manifestations of gastroesophageal reflux disease. Clinical perspective of gastroenterology, hepatology 2003; (1): 27-30.

2018_1_042-045.pdf414.26 KB

No votes yet