Saratov JOURNAL of Medical and Scientific Research

Effect of brain-derived neurotrophic factor on the formation of psycho-vegetative syndrome with brain injury

Year: 2016, volume 12 Issue: №3 Pages: 384-387
Heading: Neurology Article type: Original article
Authors: Selyanina N.V., Karakulova J.V.
Organization: Perm State University of Medicine n.a. Academician Ye.A. Vagner of Ministry of Health of the Russian Federation

Aim: to determine the role of brain-derived neurotrophic factor in the formation and forecasting of psycho-vegetative syndrome in patients with cerebral mild to moderate injury. Material and Methods. There have been 150 patients with contusion of the brain, examined. Indicators of neurological, psycho-vegetative status, quantitative content of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in the serum were studied. Results. At patients with brain contusion neurological, psycho-vegetative disturbances and decrease neurotrophic factors are determined. It was found to depend of the content of BDNF and psycho-vegetative indicators. Conclusion. The level of brain-derived neurotrophic factor serum (less than 300 pg/ml) is a predictor of psycho-vegetative syndrome in the long term of the brain injury.

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