Impact of atopic dermatitis and comorbidities on adult patient's life (Review)
Year: 2025, volume 21 Issue: №1 Pages: 74-79
Heading: Public health, organization and sociology of health care Article type: Review
Authors: Grebennikova I.P., Ardalina O.O., Epifanova A.Yu., Morrison A.V., Yeremina M.G.
Organization: Saratov State Medical University
Heading: Public health, organization and sociology of health care Article type: Review
Authors: Grebennikova I.P., Ardalina O.O., Epifanova A.Yu., Morrison A.V., Yeremina M.G.
Organization: Saratov State Medical University
Summary:
Objective: determine structural patterns of disease burden of atopic dermatitis (AD) and comorbid conditions in adult patients. Methodology for writing a review. A literature search was conducted using Medline, PubMed, and eLibrary databases. Search terms included: "atopic dermatitis", "burden of disease", "comorbid conditions". The number of sources considered is 53. For the final analysis on the issue under consideration, 32 sources from 2006 to 2023 were included, reflecting the influence of structural patterns on the quality of life of adult patients with AD. Conclusion. The disease burden of AD in an adult cohort of patients is reflected in the structural components of quality of life. Self-perception, psychosocial, academic and professional spheres are most affected by AD and are structural patterns of the true disease burden. Reduced physical activity and missed educational opportunities in childhood, affecting adulthood, reflect the hidden disease burden. Clinical features of the dermatosis: hereditary, chronic, recurrent nature of the disease, dysfunction of the skin barrier, increased risk of comorbid conditions reflect the individual disease burden. The degree of impact of AD on the quality of life of not only patients but also their family members demonstrates the cumulative burden of the disease. The economic component of the cost of the disease, as well as indirect costs associated with a decrease in the working capacity and productivity of patients, reflect the high index of the negative impact of AD.
Bibliography:
1. Yew YW, Thyssen JP, Silverberg Jl. A systematic review and meta-analysis of the regional and age-related differences in atopic dermatitis clinical characteristics. J Am Acad Dermatol 2019;80(2):390-401. DOI:10.1016/j.jaad.2018.09.035
2. Kim J, Kim BE, Leung DYM. Pathophysiology of atopic dermatitis: Clinical implications. Allergy Asthma Proc. 2019;40 (2):84-92. DOI:10.2500/aap.2019.40.4202
3. Ha DL, Park GH, Kim HS, et al. Clinical and laboratory differences between early-onset and late-onset adult atopic dermatitis. J Cutan Med Surg. 2020;24 (4):360-6. DOI:10.1177/1203475420921385
4. Kubanov AA, Bogdanova EV. Performance results of medical organizations providing medical care in the field of dermatovenereology in 2019-2021 in the Russian Federation. Vestnik Dermatologii i Venerologii. 2022;98 (5) 18-33. DOI:10.25208/vdv1337
5. Atopic dermatitis. Clinical recommendations of the Russian Federation. 2024. URL: https://diseases.medelement.com/dis-еазе/атопический-дерматит-кр-рф-2024/18203 (25 Dec 2024).
6. Eichenfield LF, Tom WL, Chamlin SL, et al. Guidelines of care for the management of atopic dermatitis: Section 1. Diagnosis and assessment of atopic dermatitis. J Am Acad Dermatol. 2014;70(2):338-51. DOI:10.1016/j.jaad.2013.10.010
7. Margolis JS, Abuabara K, Bilker W, et al. Persistence of mild to moderate atopic dermatitis. JAMA Dermatol. 2014;150 (6):593-600. DOI:10.1001/jamadermatol.2013.10271
8. Kim JP, Chao LX, Simpson EL, Silverberg Jl. Persistence of atopic dermatitis (AD): A systematic review and meta-analysis. J Am Acad Dermatol. 2016;75 (4):681-7. e11. DOI:10.1016/j.jaad.2016.05.028
9. von Stulpnagel CC, Augustin M, Dupmann L, et al. Mapping risk factors for cumulative life course impairment in patients with chronic skin diseases — A systematic review. J Eur Acad Dermatol Venereol. 2021;35 (11 ):2166-84. DOI:10.1111/jdv.17348
10. Eremina MG. Changes in the main determinants of the quality of life in people of working age with chronic skin diseases. Saratov Journal of Medical Scientific Research. 2012;8 (2): 621-6.
11. Bezmelnitsyna LYu, Fearless YaK, Zolotarev PN, et al. The burden of atopic dermatitis in modern conditions. Health Care Manager. 2022;7:52-67. DOI:10.21045/1811-0185-2022-7-52-67
12. Astafieva NG, Yeryomina MG, Yeryomin AV. Individual burden of atopic dermatitis. Saratov Journal of Medical Scientific Research. 2013:9 (3):543-8.
13. Bickers DR, Lim HW, Margolis D, et al; American Academy of Dermatology Association; Society for Investigative Dermatology. The burden of skin diseases: 2004: A joint project of the American Academy of Dermatology Association and the Society for Investigative Dermatology. J Am Acad Dermatol. 2006;55 (3):490-500. DOI:10.1016/j.jaad.2006.05.048
14. Filanovsky MG, Pootongkam S, Tamburro JE, et al. The financial and emotional impact of atopic dermatitis on children and their families. J Pediatr. 2016;169:284-90. DOI:10.1016/j. jpeds.2015.10.077
15. Silverberg Jl, Garg NK, Paller AS, et al. Sleep disturbances in adults with eczema are associated with impaired overall health: A US population-based study. J Invest Dermatol. 2015;135 (1):56-66. DOI:10.1038/jid.2014.325
16. Krysanov IS, Krysanova VS, Karpov Ol, Ermakova VYu. The economic burden of severe atopic dermatitis in the Russian
Federation. Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice. 2019;4;4-14.
17. Ring J, Alomar A, Bieber Т, et al; European Dermatology Forum (EDF); European Academy of Dermatology and Venere-ology (EADV); European Federation of Allergy (EFA); European Task Force on Atopic Dermatitis (ETFAD); European Society of Pediatric Dermatology (ESPD); Global Allergy and Asthma European Network (GA2LEN). Guidelines for treatment of atopic eczema (atopic dermatitis) part I. J Eur Acad Dermatol Venereol. 2012;26(8):1045-60. DOI:10.1111/j.1468-3083.2012.04635.x
18. DaVeiga SP Epidemiology of atopic dermatitis: A review. Allergy Asthma Proc. 2012;33 (3):227-34. DOI:10.2500/aap.2012.33.3569
19. Malik K, Heitmiller KD, Czarnowicki T. An update on the pathophysiology of atopic dermatitis. Dermatol Clin. 2017;35 (3):317-26. DOM 0.1016/j.det.2017.02.006
20. Wollina U. Microbiome in atopic dermatitis. Clin Cosmet Investig Dermatol. 2017;10:51-6. DOM0.2147/CCID.S130013
21. Rerknimitr P, Otsuka A, Nakashima C, Kabashima K. The etiopathogenesis of atopic dermatitis: Barrier disruption, immuno-logical derangement, and pruritus. Inflamm Regen. 2017;37:14. DOI:10.1186/S41232-017-0044-7
22. Blicharz L, Rudnicka L, Samochocki Z. Staphylococcus aureus: An underestimated factor in the pathogenesis of atopic dermatitis? Postep Dermatol Alergol. 2019;36 (1):11-7. DOI:10.5114/ada.2019.82821
23. Olisova OYu, Svitich OA, Poddubikov AV, et al. Microbiological assessment of the effectiveness of standard therapy for atopic dermatitis. Bulletin of Dermatology and Venereology 2023;99 (3):44-52. DOI:10.25208/vdv1364
24. Mansouri Y, Guttman-Yassky E. Immune pathways in atopic dermatitis, and definition of biomarkers through broad and targeted therapeutics. J Clin Med. 2015;4 (5):858-73. DOI:10.3390/jcm4050858
25. Silverberg NB. A practical overview of pediatric atopic dermatitis, part 2: Triggers and grading. Cutis. 2016;97 (5):326-9. PMID: 27274543
26. Silverberg NB. A practical overview of pediatric atopic dermatitis, part 1: Epidemiology and pathogenesis. Cutis. 2016;97(4):267-71. PMID: 27163911
27. Malajian D, Guttman-Yassky E. New pathogenic and therapeutic paradigms in atopic dermatitis. Cytokine. 2015;73 (2):311-8. DOI: 0.1016/j.cyto.2014.11.023
28. Yu SH, Silverberg Jl. Association between atopic dermatitis and depression in US adults. J Invest Dermatol. 2015;135 (12):3183-6. DOI:10.1038/jid.2015.337
29. Pavlova OV. Social and psychological aspects of atopic dermatitis and psoriasis. Bulletin of the Russian State Medical University. 2009;5:64-7.
30. Zhang A, Silverberg Л. Association of atopic dermatitis with being overweight and obese: A systematic review and metaanalysis. J Am Acad Dermatol. 2015;72 (4):606-16.e4. DOI:10.1016/j.jaad.2014.12.013
31. Silverberg Jl. Atopic disease and cardiovascular risk factors in US children. J Allergy Clin Immunol. 2016;137 (3):938-40. e1. DOI: 0.1016/j.jaci.2015.09.012
32. Drucker AM, Li WQ, Cho E, et al. Atopic dermatitis is not independently associated with nonfatal myocardial infarction or stroke among US women. Allergy. 2016;71 (10): 1496-500. DOI:10.1111 /all. 12957
| Attachment | Size |
|---|---|
| 2025_01_074-079.pdf | 584.5 KB |
Русский
English