Saratov JOURNAL of Medical and Scientific Research

Nevus sebaceus of Jadassohn: rare variants of progression, diagnostic features, and therapeutic approaches (Clinical cases)

Year: 2025, volume 21 Issue: №1 Pages: 57-61
Heading: Dermatovenerology Article type: Case report
Authors: Platonova A.V., Ponomarenko I.G., Rasskazov J.A., Kashutin S.L., Shapchits N.L.
Organization: The Almazov National Medical Research Centre, Head of Second Cerebral and Spinal Cord Tumors Department, Doctor of Medical Sciences, My Medical Center, Saint-Petersburg, Russia
Summary:

Nevus of the sebaceous glands of Jadassohn is a congenital hamartoma, which is of interest to dermatologists with the possibility of benign and malignant degeneration during the patient's life. The article describes rare manifestations of nevus: a case of a cranial nevus with a late onset in adulthood, an extracranial nevus with a large area of distribution, a clinical and dermoscopic description of an advanced malignant cranial nevus. A detailed description of the stages of the course of the nevus, its dermoscopic and pathomorphological characteristics, and approaches to therapy are also given.

Bibliography:
1. Baigrie D, Troxell T, Cook С Nevus sebaceus. Treasure Island (FL): StatPearls Publishing, 2022. PMID:29494100
2. Dwiyana RF, Hazari MN, Diana IA, et al. Schimmel-penning syndrome with large nevus sebaceous and multiple epidermal nevi. Case Rep Dermatol. 2020;12 (3):186-91. DOI:10.1159/000509992
3. Liu Y, Valdebran M, Chen J, et al. Nevus sebaceous of Jadassohn with eight secondary tumors of follicular, sebaceous, and sweat gland differentiation. Am J Dermatopathol. 2016;38 (11):861-6. DOI:10.1097/DAD.0000000000000603
4. Basu P, Erickson CP, Calame A, Cohen PR. Nevus sebaceus with syringocystadenoma papilliferum, prurigo nodularis, apocrine cystadenoma, basaloid follicular proliferation, and sebaceoma: Case report and review of nevus sebaceus-associated conditions. Dermatol Online J. 2020;26 (2):13030/qt85k968bk. DOI:10.5070/D3262047411
5. Watson IT, DeCrescenzo A, Paek SY. Basal cell carcinoma within nevus sebaceous of the trunk. Proc (Bayl Univ Med Cent). 2019;32 (3):392-3. DOI:10.1080/08998280.2019.1605776
6. Elkin V, Mitrukovskyi L, Sedova T. Particular dermatoon-cology. Part 1. Tumors, tumor-like formations and malformations of the epidermis and skin appendages. Perm: Perm publishing house LLC, 2017; p. 744.
7. Ol'shanskaya AS, Dyuzhakova AV, Shnayder NA, et al. Schimmelpenning — Feuerstein — Mims syndrome (a case report). Russian Journal of Child Neurology. 2017;12 (4):50-5. DOI:10.17650/2073-8803-2017-12-4-50-55
8. Lihua J, Feng G, Shanshan M, et al. Somatic KRAS mutation in an infant with linear nevus sebaceous syndrome associated with lymphatic malformations: A case report and literature review. Medicine (Baltimore). 2017;96 (47):e8016. DOI:10.1097/ MD.0000000000008016
9. Hsu CK, Saito R, Nanda A, et al. Systematised naevus sebaceus resulting from post-zygotic mutation in HRAS. Austra-lasJ Dermatol. 2017;58(1):58-60. DOI:10.1111/ajd.12399
10. Hsu MC, Liau JY, Hong JL, et al. Secondary neoplasms arising from nevus sebaceus: A retrospective study of 450 cases in Taiwan. J Dermatol. 2016;43 (2):175-80. DOI:10.1111/1346-8138.13070
11. Robinson AJ, Brown AP Malignant melanoma arising in sebaceous naevus (of Jadassohn): A case report. J Plast Surg Hand Surg. 2016;50 (4):249-50. DOI:10.3109/2000656X.2016.1147741
12. Mitchell BJ, Rogers GF, Wood BO A patient with Schimmelpenning syndrome and mosaic KRAS mutation. J Craniofac Surg. 2019;30:184-5. DOI:10.1097/SCS.0000000000004887
13. Minaicheva LI, Nazarenko LP, Puzyreva OA. Rare hereditary syndromes in a physician's practice: The group of epidermal nevus syndromes. Questions of Practical Pediatrics. 2012;7 (5):70-2.
14. Gaydina Т, DvornikovA, Skripkina Р, Arutyunyan G. Rationale for removing nevus sebaceus of Jadassohn in young patients. Bulletin of RSMU. 2018;3:80-3. DOI:10.24075/brsmu.2018.033
15. Molochkov VA, Mardi Sh. To the development of basal cell carcinoma on the background of nevus of the sebaceous glands of Jadasson. Almanac of Clinical Medicine. 2007; 15:232-5.
16. Bezugly A, Sedova Т, Belkov Р, et al. Nevus sebaceus of Jadassohn - high frequency ultrasound imaging and video-dermoscopy examination. Case presentation. Med Pharm Rep. 2021 ;94(1):112-7. DOI:10.15386/mpr-1658
17. Kelati A, Baybay H, Gallouj S, Mernissi FZ. Dermo-scopic analysis of nevus sebaceus of Jadassohn: A study of 13 cases. Skin Appendage Disord. 2017;3 (2):83-91. DOI:10.1159/000460258
18. Ravodin RA, Galkin VN, Potekaev NN, Novozhilo-va OL. Sebaceus nevus of Jadassohn associated with basal cell skin carcinoma. Klinicheskaya Dermatologiya i Venerologiya. 2023;22 (2):191-9. DOI:10.17116/klinderma202322021192
19. Kimbal К, Craig Е, BarrickC, UsmaniA. Malignant melanoma arising in a profilic nevus sebaceous with colonization of trichoblastoma. Am J Dermatopathol. 2023;45 (3):196-200. DOI: 10.1097/DAD/0000000000002355
20. Farci F, Rapini RP Sebaceous hyperplasia. 2022. In: StatPearls. Treasure Island (FL): StatPearls Publishing, 2023. PMID: 32965819

AttachmentSize
2025_01_057-061.pdf929.43 KB

No votes yet